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Found 4 Enz. Inhib. hit(s) with Target = 'Poly [ADP-ribose] polymerase 1' and Ligand = 'BDBM27533'
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Institutet

Curated by ChEMBL
LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Institutet

Curated by ChEMBL
LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:A FlashPlate scintillation proximity assay has been developed to identify inhibitors of PARP-1. The mechanism of action of the assay requires the bin...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Institutet

Curated by ChEMBL
LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)
Affinity DataIC50:  7nMAssay Description:Inhibitory activity against PARP1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Institutet

Curated by ChEMBL
LigandPNGBDBM27533(4-(3-(1,4-diazepane-1-carbonyl)-4-fluorobenzyl)pht...)
Affinity DataKd:  19nMAssay Description:Binding affinity to human PARP1 by isothermal titration colorimetryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed