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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Toll-like receptor 8' and Ligand = 'BDBM50236191'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))
BDBM50236191
PNG
(CHEMBL4083025)
Show SMILES CCCCNc1nc(N)nc(C)c1CCCN1CCSCC1
Show InChI InChI=1S/C16H29N5S/c1-3-4-7-18-15-14(13(2)19-16(17)20-15)6-5-8-21-9-11-22-12-10-21/h3-12H2,1-2H3,(H3,17,18,19,20)
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Similars

Article
PubMed
n/an/an/an/a 167n/an/an/an/a



University of Minnesota

Curated by ChEMBL


Assay Description
Agonist activity at human TLR8 expressed in HEK293 cells co-expressing secreted alkaline phosphatase assessed as induction of NF-kappaB/AP-1 promoter...


J Med Chem 60: 2084-2098 (2017)


Article DOI: 10.1021/acs.jmedchem.6b01860
BindingDB Entry DOI: 10.7270/Q27083QG
More data for this
Ligand-Target Pair