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Compile Data Set for Download or QSAR

Found 1 hit Enz. Inhib. hit(s) with Target = 'Toll-like receptor 8' and Ligand = 'BDBM507039'   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Toll-like receptor 8


(Homo sapiens (Human))
BDBM507039
PNG
(2-Amino-8-(1,4-dihydropyrido[3,4-d]pyrimidin-2-yl)...)
Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccncc2N1
Show InChI InChI=1S/C24H28N6O/c1-3-9-30(10-4-2)24(31)19-11-16-5-6-17(12-20(16)28-22(25)13-19)23-27-14-18-7-8-26-15-21(18)29-23/h5-8,11-12,15H,3-4,9-10,13-14H2,1-2H3,(H2,25,28)(H,27,29)
PDB

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UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 3n/an/an/an/a



Hoffmann-La Roche Inc.

US Patent


Assay Description
For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...


US Patent US11046671 (2021)

More data for this
Ligand-Target Pair