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Found 2 Enz. Inhib. hit(s) with Target = 'Tyrosine-protein kinase JAK2' and Ligand = 'BDBM50300196'
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)
Affinity DataKi:  0.00100nMAssay Description:Inhibition of recombinant JAK2Checked by AuthorMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50300196(10-(4-hydroxyphenyl)-8,13,15-triazatetracyclo[9.6....)
Affinity DataIC50:  270nMAssay Description:Inhibition of JAK2 in human TF1 cells assessed as inhibition of GMCSF-induced STAT5 phosphorylation by flow cytometryChecked by AuthorMore data for this Ligand-Target Pair