Compile Data Set for Download or QSAR
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Found 64 of Enz. Inhib. data with enzyme = 'Caspase-1' and Substrate = 'to-be-curated'
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM572147(US11447497, Example 4)
Affinity DataIC50:  2nMAssay Description:Caspase-1 was diluted to 10 U/μl in assay buffer consisting of 50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol and 10 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM572145(US11447497, Example 2)
Affinity DataIC50:  4nMAssay Description:Caspase-1 was diluted to 10 U/μl in assay buffer consisting of 50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol and 10 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM572144(US11447497, Example 1)
Affinity DataIC50:  9nMAssay Description:Caspase-1 was diluted to 10 U/μl in assay buffer consisting of 50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol and 10 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM572146(US11447497, Example 3)
Affinity DataIC50:  65nMAssay Description:Caspase-1 was diluted to 10 U/μl in assay buffer consisting of 50 mM HEPES, pH 7.4, 100 mM NaCl, 0.1% CHAPS, 1 mM EDTA, 10% glycerol and 10 mM D...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50:  400nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160813(US10167313, Compound 82 | US9045524, 82)
Affinity DataIC50:  500nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160819(US10167313, Compound 88 | US9045524, 88)
Affinity DataIC50:  700nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160790(US10167313, Compound 57 | US9045524, 57)
Affinity DataIC50:  900nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160798(US10167313, Compound 65 | US9045524, 65)
Affinity DataIC50:  1.20E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160827(US10167313, Compound 96 | US9045524, 96)
Affinity DataIC50:  1.30E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160792(US10167313, Compound 59 | US9045524, 59)
Affinity DataIC50:  1.40E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160786(US10167313, Compound 53 | US9045524, 53)
Affinity DataIC50:  2.00E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76312(1-(4-acetylphenyl)-3-(4-chlorophenyl)urea | 1-(4-c...)
Affinity DataIC50:  2.98E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160784(US10167313, Compound 51 | US9045524, 51)
Affinity DataIC50: >3.00E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160794(US10167313, Compound 61 | US9045524, 61)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160801(US10167313, Compound 68 | US9045524, 68)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160781(US10167313, Compound 48 | US9045524, 48)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160783(US10167313, Compound 50 | US9045524, 50)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160796(US10167313, Compound 63 | US9045524, 63)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160816(US10167313, Compound 85 | US9045524, 85)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160808(US10167313, Compound 76 | US9045524, 76)
Affinity DataIC50: >3.33E+3nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM67953(1-(3-chlorophenyl)-3-(1-phenyltetrazol-5-yl)sulfan...)
Affinity DataIC50:  5.13E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76315((E)-N'-(2-propoxyphenyl)-2-butenediamide | (E)-N'-...)
Affinity DataIC50:  5.33E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76310(2-Phenyl-1-(4-propoxy-phenyl)-3-pyrrolidin-1-yl-pr...)
Affinity DataIC50:  5.80E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM64746(3-[1-(2-chloranyl-6-fluoranyl-phenyl)-2-nitro-ethy...)
Affinity DataIC50:  6.44E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM66466((Z)-1,4-bis(4-methylphenyl)-2-butene-1,4-dione | (...)
Affinity DataIC50:  6.51E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76321(3-chloranyl-N-[3-(dimethylamino)propyl]-N-(6-methy...)
Affinity DataIC50:  6.52E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76320(5-[chloranyl-[1-(4-methylphenyl)-1,2,3,4-tetrazol-...)
Affinity DataIC50:  6.59E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76331(1-(3,6-dichloro-9-carbazolyl)-3-(1-piperidinyl)-2-...)
Affinity DataIC50:  7.10E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM54734((Z)-4-(3-nitroanilino)-4-oxo-2-butenoic acid methy...)
Affinity DataIC50:  7.10E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM61638((E)-2-cyano-3-(5-nitro-2-furanyl)-N-(1-phenylethyl...)
Affinity DataIC50:  9.51E+3nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM160788(US10167313, Compound 55 | US9045524, 55)
Affinity DataIC50: >1.00E+4nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM314073(US10167313, Compound 71 | Z-Asp-(D,L Ala(2'-quinol...)
Affinity DataIC50: >1.00E+4nMAssay Description:Selectivity of compound 55, compound 63, compound 48, compound 57, compound 88 toward caspase-1 (pro-inflammatory group), caspase-5 (group I), caspas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM54332(4-[3-(4-aminophenoxy)phenoxy]aniline | 4-[3-(4-aza...)
Affinity DataIC50:  1.02E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM50282105(2-Hydroxy-N-(3-phenyl-propyl)-benzamide | CHEMBL29...)
Affinity DataIC50:  1.15E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76309(1-[6-(4-Fluoro-phenoxy)-hexyl]-4-(2-methoxy-phenyl...)
Affinity DataIC50:  1.32E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76329(2-methyl-N-(5-thiophen-2-yl-1,3,4-thiadiazol-2-yl)...)
Affinity DataIC50:  1.50E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM61402((Z)-2-butenedioic acid;2-(2,2-dicyclohexylethyl)pi...)
Affinity DataIC50:  1.59E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76330(MLS000679904 | N-({2-[4-(pentanoylamino)benzoyl]hy...)
Affinity DataIC50:  1.88E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM68054(5-(4-chlorophenyl)sulfonyl-1-methyl-4-nitro-imidaz...)
Affinity DataIC50:  1.98E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76318(2-(2,5-Dioxo-1-p-tolyl-pyrrolidin-3-ylsulfanyl)-be...)
Affinity DataIC50:  2.06E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM66426(1-(4,5-dimethyl-2-nitro-phenyl)-3-pyrroline-2,5-qu...)
Affinity DataIC50:  2.39E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM52505(1H-imidazo[4,5-b]phenazine | MLS000700045 | SMR000...)
Affinity DataIC50:  3.27E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76313(4-(2,4-dichlorophenoxy)-N-isopropyl-butyramide | 4...)
Affinity DataIC50:  3.58E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76314(2-(4-isopropoxyanilino)-N-(p-tolyl)acetamide | MLS...)
Affinity DataIC50:  4.26E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76319((5Z)-3-(1,1-diketothiolan-3-yl)-5-(3-pyridylmethyl...)
Affinity DataIC50:  4.91E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76316(2,4-bis(chloranyl)-N-(4-pyrrol-1-ylphenyl)benzenes...)
Affinity DataIC50:  5.68E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM76308((5-methyl-2-pyridin-4-yl-1,3-thiazol-4-yl) benzoat...)
Affinity DataIC50:  5.69E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
TargetCaspase-1(Homo sapiens (Human))
Histogen

US Patent
LigandPNGBDBM42770(3-[(5-methylthiophene-3-carbonyl)amino]thiophene-2...)
Affinity DataIC50:  6.04E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute (SBMRI, San Diego, C...More data for this Ligand-Target Pair
In DepthDetails PCBioAssay
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