Found 79 of ic50 for monomerid = 21278 
Affinity DataIC50: 1.35nMAssay Description:Inverse agonist at human CB1 receptor expressed in SF9 cells assessed as decrease in GTPgammaS levelMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebella membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:Displacement of [3H]CP55940 from human CB2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:Agonist activity at human CB1 receptor assessed as stimulation of [35S]GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 2.20nMAssay Description:Binding affinity to human CB1 receptor by [35S]GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Binding affinity to CB1 receptor in rat brain synaptosomal membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cell membranes assessed as suppression of [35S]GTPgammaS binding incubated for 60 ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in HEK293 cell membranes assessed as suppression of [35S]GTPgammaS binding incubated for 60 ...More data for this Ligand-Target Pair
Affinity DataIC50: 2.90nMAssay Description:Inverse agonist activity at human CB1 receptor expressed in CHO-K1 cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMpH: 7.4 T: 2°CAssay Description:A GTP-gamma-S CB1 functional assay was used to assess the potency of the pyrazine derivatives. [35S]GTP-gamma-S binding assays were performed at 30 d...More data for this Ligand-Target Pair
Affinity DataIC50: 3.20nMAssay Description:Antagonist activity at human cannabinoid CB1 receptor expressed in CHO cells coexpressing Galpha15/16 assessed as inhibition of CP55940-induced Ca2+ ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Antagonist activity at CB1 receptor transfected in CHO cells expressing apoaequorin as a reporter for G-protein-coupled receptor-mediated calcium sig...More data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-induced GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Inhibition of cannabinoid CB1 receptor in Sprague-Dawley rat brainMore data for this Ligand-Target Pair
Affinity DataIC50: 4.5nMAssay Description:Antagonist activity at human recombinant CB1 receptor expressed in CHO-K1 cells assessed as inhibition of CP55940-stimulated GTPgammaS bindingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.53nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebellum by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 4.53nMAssay Description:Displacement of [3H]CP-55940 from CB1 receptor in Sprague-Dawley rat cerebellum after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 4.53nMAssay Description:Displacement of [3H]CP55,940 from CB1 receptor in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 4.60nMAssay Description:Displacement of [3H]-rimonabant from human CB1 receptor expressed in CHO cell membranes after 60 mins by TopCount methodMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Cricetulus griseus (Chinese hamster))
Nanchang University School Of Pharmaceutical Science
Nanchang University School Of Pharmaceutical Science
Affinity DataIC50: 4.72nMAssay Description:The target compounds were evaluated using a binding assay towards the CB1 receptor expressed on the membranes of Chinese hamster ovarian (CHO) cells....More data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP55940 from CB1 receptor in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP55940 from CB1R in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP55,940 from cannabinoid CB1 receptor in Sprague-Dawley rat cerebellar membrane by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP55940 from cannabinoid CB1 receptor in Sprague-Dawley rat cerebellar membrane by liquid scintillation spectrometryMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Displacement of [3H]CP55,940 from CB1 receptor in Sprague-Dawley rat cerebellar membraneMore data for this Ligand-Target Pair
Affinity DataIC50: 5.10nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in COS7 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20nMAssay Description:Displacement of [3H]WIN55,212-2 from CB1 receptor in rat cerebellar membrane by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: 5.30nMAssay Description:Inhibition of CYP2C9 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibitory concentration against human recombinant cannabinoid receptor type 1 expressed in Chinese Hamster Ovary (CHO) cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Inhibition of [3H]CP-55940 binding to human recombinant CB1 receptor in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.10nMAssay Description:Displacement of [3H]CP55940 from human recombinant CB1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 6.20nMAssay Description:Inhibitory concentration tested against human Cannabinoid receptor 1 (hCB1)More data for this Ligand-Target Pair
Affinity DataIC50: 6.90nMAssay Description:Displacement of [3H]-CP-55940 from human CB1 receptor expressed in CHO-K1 cell membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 9.70nMAssay Description:Antagonist activity at human CB1 receptor expressed in CHO cell membranes assessed as reduction in GTPgammaS binding after 30 mins by microbeta count...More data for this Ligand-Target Pair
Affinity DataIC50: 11.2nMAssay Description:Antagonist activity against human CB1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Antagonist activity at CB1 receptor (unknown origin) expressed in CHO cells up to 10 uM incubated for 10 mins prior to CP55940 addition by calcium mo...More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Antagonist activity at human CB1 receptor stably expressed in CHO cells co-expressing co-expressing Ga15/16 assessed as calcium current after 45 mins...More data for this Ligand-Target Pair
Affinity DataIC50: 13.2nMAssay Description:Displacement of [3H]CP55940 from human recombinant CB1R expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Antagonist activity against CB1R (unknown origin) CHO cells stably expressing Galpha16 assessed as inhibition of CP55940-induced increase in intracel...More data for this Ligand-Target Pair
Affinity DataIC50: 14nMAssay Description:Inhibition of CB1 receptor (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Displacement of [3H]CP55940 from human CB1 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 18nMpH: 7.4Assay Description:Displacement of [3H]SR141716A from rat brain CB1 receptor at pH 7.4 after 1 hr by liquid scintillation countingMore data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:Inhibition of CYP2D6 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:Inhibition of CYP1A2 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
Affinity DataIC50: >20nMAssay Description:Inhibition of CYP3A4 in human liver microsomes after 30 minsMore data for this Ligand-Target Pair
TargetCannabinoid receptor 1(Mus musculus (Mouse))
National Institute On Alcohol Abuse And Alcoholism
Curated by ChEMBL
National Institute On Alcohol Abuse And Alcoholism
Curated by ChEMBL
Affinity DataIC50: 25nMAssay Description:Inverse agonist at mouse brain CB1R expressed in CHOK1 cell membranes assessed as inhibition of CP55940-stimulated [35S]GTP-gammaS binding measured a...More data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inverse agonist activity against CB1 receptor expressed in human CHO cells assessed as effect on forskolin-stimulated cAMP levelMore data for this Ligand-Target Pair
Affinity DataIC50: 92.5nMAssay Description:Binding affinity to human CB2 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataIC50: 108nMAssay Description:Inverse agonist activity at human recombinant CB1 receptor expressed in CHO cells by luciferase reporter gene assayMore data for this Ligand-Target Pair
