Compile Data Set for Download or QSAR
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Found 13 of ic50 for monomerid = 24656
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  1.50E+3nMAssay Description:A commercially available P450-GLO Assay kit (Promega Corporation, Madison Wis.) is used to screen various compounds for CYP3A4A inhibition activity. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  1.50E+3nMAssay Description:Cytochrome P450 is a large and diverse group of enzymes that catalyze the oxidation of organic substances. Some members of the CYP family contribute ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 2B1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  7.40E+3nMAssay Description:Inhibition of Aminopyrine N-demethylase in Phenobarbitone-treated ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  3.10E+4nMAssay Description:Inhibition of recombinant human IDO1 expressed in bacterial expression system using L-Tryptophan as substrate after 25 mins in absence of GSH and twe...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCytochrome P450 1A1(Rattus norvegicus)
TBA

Curated by ChEMBL
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  3.30E+4nMAssay Description:Inhibition of Aryl hydrocarbon hydroxylase in phenobarbitone-treated ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  3.80E+4nMAssay Description:Inhibition of recombinant human IDO1 expressed in bacterial expression system using L-Tryptophan as substrate after 25 mins in absence of GSH and pre...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  4.20E+4nMAssay Description:Inhibition of recombinant human IDO1 expressed in bacterial expression system using L-Tryptophan as substrate after 25 mins in presence of GSH and tw...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  4.80E+4nMAssay Description:Inhibition of human IDO1 expressed in Escherichia coli BL21 (DE3) using L-tryptophan as substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  4.80E+4nMpH: 6.5 T: 2°CAssay Description:The IC50 inhibition assays were performed in a 96-well microtiter plate format using purified recombinant IDO, which was added to the substrate, L-tr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  5.88E+4nMpH: 7.4 T: 2°CAssay Description:Microsomal preparation: One lobe of fresh pig liver is obtained (e.g., at about the time of slaughter from a food-processing company) and immediately...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCytochrome P450 3A4(Homo sapiens (Human))
The Procter & Gamble

US Patent
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  5.88E+4nMpH: 7.4Assay Description:All procedures were carried out under minimal light in order to prevent degradation of the retinoid samples.Microsomal preparation: one lobe of fresh...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  7.03E+4nMAssay Description:Inhibition of human recombinant N-terminus 6X-histidine-tagged indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as inhibition of L-...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
University Of Auckland

Curated by ChEMBL
LigandPNGBDBM24656(4-PIM | 4-Phenylimidazole | 4-phenyl-1H-imidazole ...)
Affinity DataIC50:  4.28E+5nMAssay Description:Inhibition of full length recombinant human His-tagged IDO1 expressed in mouse LLTC cells using L-tryptophan as substrate after 24 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB