Affinity DataIC50: 1nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
Affinity DataIC50: 1.5nMAssay Description:Inhibition of aurora A kinaseMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant mouse Aurora A kinase expressed in Sf9 cells using Biotin-GLRRASLG as substrate in presence of [gamma33]P-ATP by FlashPlate...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of GST-tagged recombinant mouse Aurora A expressed in Sf9 cells using biotin-GLRRASLG as peptide substrate by [gamma-33S]ATP binding assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse recombinant Aurora A kinase expressed in insect Sf9 cells by radioactive flashplate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of Aurora A kinase (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of recombinant mouse GST-tagged Aurora A expressed in insect Sf9 cells using Biotin-GLRRASLG as substrate in presence of [gamma33P]ATP by ...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of aurora A kinaseChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMT: 2°CAssay Description:Inhibition of Aurora A was assessed in duplicated radiometric assay containing 100uM [gamma-32P] ATP and quantified by p81 phosphocellulose assay.More data for this Ligand-Target Pair
Affinity DataIC50: 9.10nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
Affinity DataIC50: 9.30nMpH: 7.5 T: 2°CAssay Description:Aurora kinase was assayed in ELISA format using a GST fusion of the N-terminus of Histone H3 as substrate. Plates were coated with substrate, and the...More data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 2(Homo sapiens (Human))
Boehringer Ingelheim International
US Patent
Boehringer Ingelheim International
US Patent
Affinity DataIC50: 13nMpH: 7.4 T: 2°CAssay Description:Inhibition of kinase activity of Mnk1 and Mnk2a was assessed with the same assay system, using pre-activated GST-Mnk1 or GST-Mnk2a, respectively. The...More data for this Ligand-Target Pair
Affinity DataIC50: 23.2nMAssay Description:In vitro kinase assay of Aurora A, B, and C using Z-LYTE technology (Invitrogen) and ATP at Km apparent for each kinase.More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of recombinant mouse aurora kinase A expressed in insect Sf9 cells using biotin-GLRRASLG as substrate in presence of [gamma-33P]ATPMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of Aurora A Thr288 autophosphorylation in human HeLa cells after 1 hrMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of aurora A autophosphorylation in human HCT116 cells by immunofluorescence methodChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of aurora kinase A autophosphorylation at T288 in human HCT116 cells by immunofluorescence analysisMore data for this Ligand-Target Pair
TargetAurora kinase B(Mus musculus)
The Key Laboratory Of Chemistry For Natural Products Of Guizhou Province And Chinese Academy Of Sciences
Curated by ChEMBL
The Key Laboratory Of Chemistry For Natural Products Of Guizhou Province And Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 172nMAssay Description:Inhibition of recombinant mouse GST-tagged Aurora B expressed in insect Sf9 cells using Biotin-TKQTARKSTGGKAPR as substrate in presence of [gamma33P]...More data for this Ligand-Target Pair
Affinity DataIC50: 172nMAssay Description:Competitive inhibition of Aurora B ATP binding siteMore data for this Ligand-Target Pair
Affinity DataIC50: 172nMAssay Description:Inhibition of aurora B kinaseChecked by AuthorMore data for this Ligand-Target Pair
TargetAurora kinase B(Mus musculus)
The Key Laboratory Of Chemistry For Natural Products Of Guizhou Province And Chinese Academy Of Sciences
Curated by ChEMBL
The Key Laboratory Of Chemistry For Natural Products Of Guizhou Province And Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 172nMAssay Description:Inhibition of GST-tagged recombinant mouse Aurora B expressed in Sf9 cells using Biotin-TKQTARKSTGGKAPR as peptide substrate by [gamma-33S]ATP bindin...More data for this Ligand-Target Pair
TargetAurora kinase B(Mus musculus)
The Key Laboratory Of Chemistry For Natural Products Of Guizhou Province And Chinese Academy Of Sciences
Curated by ChEMBL
The Key Laboratory Of Chemistry For Natural Products Of Guizhou Province And Chinese Academy Of Sciences
Curated by ChEMBL
Affinity DataIC50: 172nMAssay Description:Inhibition of mouse recombinant Aurora B kinase expressed in insect Sf9 cells by radioactive flashplate assayMore data for this Ligand-Target Pair
TargetGamma-aminobutyric acid receptor subunit alpha-1(Homo sapiens (Human))
Takeda Pharmaceutical
Curated by ChEMBL
Takeda Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 330nMAssay Description:Binding affinity to GABAA alpha-1 benzodiazepine binding site (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 794nMAssay Description:Inhibition of PDGFRA (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of LCK by radioactive flashplate assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of aurora B in human HCT116 cells assessed as inhibition of histone H3 Ser10 phosphorylation by immunofluorescence methodChecked by AuthorMore data for this Ligand-Target Pair
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of aurora kinase B in human HCT116 cells assessed as inhibition of histone H3 phosphorylation by immunofluorescence analysisMore data for this Ligand-Target Pair
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of Aurora B Ser10 phosphorylation in human HeLa cells after 1 hrMore data for this Ligand-Target Pair
TargetCasein kinase II subunit alpha(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.05E+4nMAssay Description:Inhibition of CK2 by radioactive flashplate assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of CHK2 by radioactive flashplate assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 5.30E+4nMAssay Description:Inhibition of PLK1 by radioactive flashplate assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Millennium Pharmaceuticals
Curated by ChEMBL
Millennium Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CHK1 by radioactive flashplate assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CDK1 by radioactive flashplate assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of CDK1More data for this Ligand-Target Pair