BindingDB PrimarySearch

Found 30 of ic50 for monomerid = 50393342

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 18nMAssay Description:Inhibition of human PI3Kgamma expressed in sf9 cells assessed as amount of ATP consumed by luciferase-luciferin chemiluminescence assayMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 18nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 206nMAssay Description:Inhibition of CRAF1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 435nMAssay Description:Inhibition of human PI3Kalpha expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Cytochrome P450 2C9(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 591nMAssay Description:Inhibition of human CYP2C9 using tolbutamide as substrate after 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Serine/threonine-protein kinase mTOR(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 623nMAssay Description:Inhibition of mTORMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Amgen

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 690nMAssay Description:Inhibition of human PI3Kdelta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescen...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Epidermal growth factor receptor(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 739nMAssay Description:Inhibition of EGFRMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 773nMAssay Description:Inhibition of human PI3Kgamma expressed in C5a-stimulated mouse RAW 264.7 cells assessed as inhibition of AKT phosphorylation by ELISAMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed PDB

3D Structure (crystal)

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 2.06E+3nMAssay Description:Inhibition of human PI3Kbeta expressed in sf9 cells coexpressing p85alpha assessed as amount of ATP consumed by luciferase-luciferin chemiluminescenc...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Cytochrome P450 2C8(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 2.33E+3nMAssay Description:Inhibition of human CYP2C8 using paclitaxel as substrate after 45 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Cell division cycle 7-related protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of CDC7More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Hepatocyte growth factor receptor(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of c-MetMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of AKT1More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of JAK2More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of CDK1/CyclinBMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia antibodypedia antibodypedia antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Serine/threonine-protein kinase Chk1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of CHK1More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Aurora kinase B(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of Aurora kinase BMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of SRCMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Fibroblast growth factor receptor 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of FGFR1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of Flt3More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Insulin receptor(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of IRKMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Platelet-derived growth factor receptor beta(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of Platelet-derived growth factor subunit BMore data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

3-phosphoinositide-dependent protein kinase 1(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >3.60E+3nMAssay Description:Inhibition of PDK1More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Potassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: 1.73E+4nMAssay Description:Inhibition of human Erg expressed in CHO cells after 5 minsMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Cytochrome P450 1A2(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >2.00E+4nMAssay Description:Inhibition of human CYP1A2 using phenacetin as substrate after 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Cytochrome P450 2C19(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >2.00E+4nMAssay Description:Inhibition of human CYP2C19 using mephenytoin as substrate after 45 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Cytochrome P450 3A4(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >2.00E+4nMAssay Description:Inhibition of human CYP3A4 using testosterone as substrate after 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Cytochrome P450 3A4(Homo sapiens (Human))
Exelixis

Curated by ChEMBL

BDBM50393342(CHEMBL2152252)

IC50: >2.00E+4nMAssay Description:Inhibition of human CYP3A4 using midazolam as substrate after 15 mins by LC/MS/MS analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

CHEMBL MMDB PC cid PC sid PDB Similars

Details Article PubMed

Filter my 30 hits

Targets 27▿
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 2
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 2
- Cytochrome P450 3A4 2
- 3-phosphoinositide-dependent protein kinase 1 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Serine/threonine-protein kinase mTOR 1
- Cell division cycle 7-related protein kinase 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Potassium voltage-gated channel subfamily H member 2 1
- Epidermal growth factor receptor 1
- RAC-alpha serine/threonine-protein kinase 1
- Cytochrome P450 1A2 1
- Serine/threonine-protein kinase Chk1 1
- Tyrosine-protein kinase JAK2 1
- Cyclin-dependent kinase 1/G2/mitotic-specific cyclin-B1/G2/mitotic-specific cyclin-B2/G2/mitotic-specific cyclin-B3 1
- Hepatocyte growth factor receptor 1
- Platelet-derived growth factor receptor beta 1
- Cytochrome P450 2C9 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform 1
- Cytochrome P450 2C19 1
- Aurora kinase B 1
- Vascular endothelial growth factor receptor 2 1
- Insulin receptor 1
- Fibroblast growth factor receptor 1 1
- Cytochrome P450 2C8 1
Publications 2▿
- J Med Chem 55: 5467-82 (2012) 29
- J Med Chem 55: 8559-81 (2012) 1
Institutions 2▿
- Exelixis 29
- Amgen 1
Affinity: 18 to 2.0E+4 nM▿
- IC50 30
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0