Affinity DataIC50: 0.0400nMAssay Description:Compound was tested for its inhibitory activity against Alpha-1 adrenergic receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 0.200nMAssay Description:Compound tested for its inhibitory activity against Histamine H1 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of uptake of 5-HT in rat brain cortexMore data for this Ligand-Target Pair
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Sogang University
Curated by ChEMBL
Sogang University
Curated by ChEMBL
Affinity DataIC50: 65nMAssay Description:Displacement of [3H]Nisoxetine from human recombinant NET over-expressed in dog MDCK cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:Inhibition of 5-HT transporter in NMRI albino mouse brain assessed as [3H]5-HT accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 70nMAssay Description:In vivo inhibition of uptake of 5-HT in human plateletsMore data for this Ligand-Target Pair
Affinity DataIC50: 90nMAssay Description:In vitro inhibition of accumulation of [14C]-5-HT (5-HT) in mouse brain slicesMore data for this Ligand-Target Pair
Affinity DataIC50: 700nMAssay Description:Inhibition of uptake of noradrenaline in rat brain hypothalamusMore data for this Ligand-Target Pair
TargetHistamine H2 receptor(Cavia porcellus (domestic guinea pig))
Universidad De Valencia
Curated by ChEMBL
Universidad De Valencia
Curated by ChEMBL
Affinity DataIC50: 720nMAssay Description:Inhibitory activity against brain adenylate cyclase Histamine H2 receptorMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:Inhibition of noradrenaline transporter in NMRI albino mouse brain assessed as [3H]NA accumulation in hypothalamus after 5 minsMore data for this Ligand-Target Pair
Affinity DataIC50: 900nMAssay Description:In vitro inhibition of accumulation of (-)-[3H]-Norepinephrine (NA) in mouse brain slicesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of uptake of dopamine (DA) rat brain striatumMore data for this Ligand-Target Pair
Affinity DataIC50: 2.78E+3nMAssay Description:Displacement of [3H]Win35428 from human recombinant DAT over-expressed in CHOK1 cellsMore data for this Ligand-Target Pair
Affinity DataIC50: 3.40E+3nMAssay Description:Inhibition of recombinant Trypanosoma brucei brucei strain S427 trypanothione reductase assessed as reduction of trypanothione disulphide by 412 nm a...More data for this Ligand-Target Pair
Affinity DataIC50: 3.80E+3nMAssay Description:Inhibition of Trypanosoma cruzi TryR measured after 15 mins in presence of NADPHMore data for this Ligand-Target Pair
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
The University Of Queensland
Curated by ChEMBL
The University Of Queensland
Curated by ChEMBL
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of endogenous human CaV2.2 in human SH-SY5Y cells in presence of nifedipine by Calcium 4 dye based calcium influx fluorescence-imaging ass...More data for this Ligand-Target Pair
Affinity DataIC50: <1.00E+4nMAssay Description:Inhibition of binding of Batrachotoxinin [3H]BTX-B to high affinity sites on voltage dependent sodium channels in a vesicular preparation from guinea...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(RAT)
Jagiellonian University
Curated by ChEMBL
Jagiellonian University
Curated by ChEMBL
Affinity DataIC50: 1.16E+4nMAssay Description:Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytesMore data for this Ligand-Target Pair
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21(DE3) assessed as reduction of oxidized trypanothione prein...More data for this Ligand-Target Pair
Affinity DataIC50: 1.52E+4nMAssay Description:Inhibition of Trypanosoma cruzi trypanothione reductase expressed in Escherichia coli BL21 (DE3) pre-incubated for 30 mins using TS2 substrate in pre...More data for this Ligand-Target Pair
Affinity DataIC50: 1.93E+4nMAssay Description:Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopyMore data for this Ligand-Target Pair
Affinity DataIC50: 3.74E+4nMAssay Description:Inhibition of human BSEP expressed in baculovirus transfected fall armyworm Sf21 cell membranes vesicles assessed as reduction in ATP-dependent [3H]-...More data for this Ligand-Target Pair
TargetMitochondrial import inner membrane translocase subunit TIM10(Saccharomyces cerevisiae S288c)
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Burnham Center For Chemical Genomics
Curated by PubChem BioAssay
Affinity DataIC50: 3.78E+4nMAssay Description:Data Source: Sanford-Burnham Center for Chemical Genomics (SBCCG) Source Affiliation: Sanford-Burnham Medical Research Institute(SBMRI, San Diego, CA...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP2 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP4 overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ATP and...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human MRP3 overexpressed in Sf9 insect cell membrane vesicles assessed as uptake of [3H]-estradiol-17beta-D-glucuronide in presence of ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.33E+5nMAssay Description:Inhibition of human BSEP overexpressed in Sf9 cell membrane vesicles assessed as uptake of [3H]-taurocholate in presence of ATP measured after 15 to ...More data for this Ligand-Target Pair
Affinity DataIC50: >1.35E+5nMAssay Description:Inhibition of human BSEP expressed in fall armyworm sf9 cell plasma membrane vesicles assessed as reduction in vesicle-associated [3H]-taurocholate t...More data for this Ligand-Target Pair