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PDB Reactome pathway KEGG
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Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50230392(CHEMBL554581)

EC50: 0.00770nMAssay Description:Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aortaMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM50470944(CHEMBL336161)

EC50: 5.20nMAssay Description:In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM50118703(CHEMBL109783 | N-[5-(4,5-Dihydro-1H-imidazol-2-yl)...)

EC50: 5.80nMAssay Description:In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensMore data for this Ligand-Target Pair

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3D Structure (crystal)

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50001922(2-Naphthalen-1-ylmethyl-4,5-dihydro-1H-imidazole; ...)

EC50: 12nMAssay Description:Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aortaMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50027031((2-Chloro-phenyl)-(4,5-dihydro-1H-imidazol-2-ylmet...)

EC50: 50nMAssay Description:Agonist activity against alpha-1 adrenergic receptor from rat vas deferensMore data for this Ligand-Target Pair

CHEMBL PC cid PC sid Patents

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50027035(3-[(4,5-Dihydro-1H-imidazol-2-ylmethyl)-amino]-phe...)

EC50: 61nMAssay Description:Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligandMore data for this Ligand-Target Pair

CHEMBL PC cid PC sid Patents

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50036910(4-(1-Naphthalen-1-yl-ethyl)-1H-imidazole | CHEMBL3...)

EC50: 153nMAssay Description:50% Molar effective concentration for agonistic activity against Alpha-1 adrenergic receptor in rat aortaMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50230388(CHEMBL537830)

EC50: 200nMAssay Description:Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aortaMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50230389(CHEMBL541105)

EC50: 200nMAssay Description:Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aortaMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50036913((+-)-4-(alpha,2,3-trimethylbenzyl)imidazole | 4-[1...)

EC50: 281nMAssay Description:50% Molar effective concentration afainst Alpha-1 adrenergic receptor in rat aortaMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM30712(6-tert-butyl-3-(2-imidazolin-2-ylmethyl)-2,4-dimet...)

EC50: 288nMAssay Description:In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50027036((4,5-Dihydro-1H-imidazol-2-ylmethyl)-methyl-p-toly...)

EC50: 300nMAssay Description:Binding affinity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]prazosin as the radioligandMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50230390(CHEBI:48556 | MEDETOMIDINE HYDROCHLORIDE | MPV-785...)

EC50: 310nMAssay Description:Compound was evaluated for Adrenergic activity against Alpha-1 adrenergic receptor from rat aortaMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50027032((4,5-Dihydro-1H-imidazol-2-ylmethyl)-p-tolyl-amine...)

EC50: 340nMAssay Description:Agonist activity against alpha-1 adrenergic receptor from rat vas deferensMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM50131411(4-(4-Chloro-benzyl)-2-methyl-2H-phthalazin-1-one |...)

EC50: 810nMAssay Description:Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)

EC50: >1.00E+3nMAssay Description:Agonist activity against alpha-1 adrenergic receptor from rat vas deferensMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM50029051((-)-arterenol | (-)-noradrenaline | (-)-norepineph...)

EC50: 1.18E+3nMAssay Description:In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM50131423(4-Benzyl-2-methyl-2H-phthalazin-1-one | 4-benzyl-2...)

EC50: 1.50E+3nMAssay Description:Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionMore data for this Ligand-Target Pair

CHEMBL PC cid PC sid Patents Similars

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50027037((4,5-Dihydro-1H-imidazol-2-ylmethyl)-ethyl-p-tolyl...)

EC50: 1.60E+3nMAssay Description:Agonist activity against alpha-1 adrenergic receptor from rat vas deferensMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM50067212(CHEBI:8093 | Cyclomydril | Duo-Medihaler | Phenyle...)

EC50: 1.66E+3nMAssay Description:In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM50131414(4-(benzo[d][1,3]dioxol-5-ylmethyl)phthalazin-1(2H)...)

EC50: 3.00E+3nMAssay Description:Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor/Alpha-1B adrenergic receptor/Alpha-1D adrenergic receptor/Alpha-2A adrenergic receptor [16-465]/Alpha-2B adrenergic receptor/Alpha-2C adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL

BDBM50019061((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)

EC50: 3.00E+3nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

BDBM35234(DL-[7-3H]norepinephrine | NOREPINEPHRINE | Noradre...)

EC50: 3.00E+3nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM56339(4-(4-chlorobenzyl)-1(2H)-phthalazinone | 4-(4-chlo...)

EC50: 3.90E+3nMAssay Description:Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM50183665(4-(4-chlorobenzyl)-2-allylphthalazin-1(2H)-one | C...)

EC50: 4.40E+3nMAssay Description:Vasorelaxation of noradrenaline-stimulated Wistar rat vas deferens contractionMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

BDBM50042998(5-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-1,2-d...)

EC50: 5.00E+3nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

BDBM50019061((+/-)4-(2-Amino-1-hydroxy-ethyl)-5-fluoro-benzene-...)

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

BDBM35234(DL-[7-3H]norepinephrine | NOREPINEPHRINE | Noradre...)

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PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50027033(CHEMBL541208 | Cyclohexyl-(4,5-dihydro-1H-imidazol...)

EC50: >1.00E+4nMAssay Description:Agonist activity against alpha-1 adrenergic receptor from rat vas deferensMore data for this Ligand-Target Pair

CHEMBL PC cid PC sid

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank GoogleScholar

Alpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
Ohio State University

Curated by ChEMBL

BDBM50027034((4,5-Dihydro-1H-imidazol-2-ylmethyl)-phenyl-p-toly...)

EC50: >1.00E+4nMAssay Description:Agonist activity against alpha-1 adrenergic receptor from rat vas deferensMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

BDBM50042998(5-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-1,2-d...)

EC50: 1.50E+4nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
GoogleScholar

Alpha-1A adrenergic receptor(Rattus norvegicus (Rat))
Abbott Laboratories

Curated by ChEMBL

BDBM50470943(CHEMBL133451)

EC50: 3.09E+4nMAssay Description:In vitro agonist potency towards Alpha-1A adrenergic receptor in rat vas deferensMore data for this Ligand-Target Pair

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Details Article PubMed PDB

3D Structure (crystal)

BDBM50019060((+/-)4-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-...)

EC50: >1.00E+5nMAssay Description:Displacement of [3H]WB4101 from alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortical membraneMore data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

PDB Reactome pathway
UniProtKB/SwissProt
GoogleScholar

BDBM50019060((+/-)4-(2-Amino-1-hydroxy-ethyl)-3-fluoro-benzene-...)

EC50: >1.00E+5nMAssay Description:Agonist activity at alpha-adrenergic receptor in Sprague-Dawley rat cerebral cortex assessed as [3H]cAMP accumulation by liquid scintillation spectro...More data for this Ligand-Target Pair