Compile Data Set for Download or QSAR
maximum 50k data
Found 2699 of ic50 for UniProtKB: P08514
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123246((S)-2-Benzenesulfonylamino-3-{[5-(4-guanidino-phen...)
Affinity DataIC50:  0.00130nMAssay Description:Inhibition of vitronectin binding to HT-29 cells expressing integrin alphaV-beta5More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123251((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidinomethy...)
Affinity DataIC50:  0.00580nMAssay Description:Inhibition of fibrinogen binding to integrin alphaV-beta3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104592((S)-3-{[3-(2-Piperidin-4-yl-ethyl)-5,6,7,8-tetrahy...)
Affinity DataIC50:  0.0160nMAssay Description:Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50346317((S)-3-(3-chloro-4-(4-(1,4,5,6-tetrahydropyrimidin-...)
Affinity DataIC50:  0.0230nMAssay Description:Antagonist activity at alpha2bbeta3 integrin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104598(2-Benzyloxycarbonylamino-3-{[(R)-1-(3-piperidin-4-...)
Affinity DataIC50:  0.0270nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104602(2-Benzyloxycarbonylamino-3-{[3-(2-piperidin-4-yl-v...)
Affinity DataIC50:  0.0410nMAssay Description:Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104595(2-Phenylmethanesulfonylamino-3-{[3-(2-piperidin-4-...)
Affinity DataIC50:  0.0430nMAssay Description:Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104591((S)-3-{[3-((E)-2-Piperidin-4-yl-vinyl)-5,6,7,8-tet...)
Affinity DataIC50:  0.0570nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104600((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50:  0.0600nMAssay Description:Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104597((S)-3-{[3-((E)-2-Piperidin-4-yl-vinyl)-5,6,7,8-tet...)
Affinity DataIC50:  0.0610nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104594(2-Benzyloxycarbonylamino-3-{[3-(2-piperidin-4-yl-e...)
Affinity DataIC50:  0.0680nMAssay Description:Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067222(CHEMBL128906 | [6-(4-Carbamimidoyl-benzoylamino)-c...)
Affinity DataIC50:  0.0730nMAssay Description:Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50098965(3-{2-[(Z)-4-Carbamimidoyl-benzoylimino]-3,4-dimeth...)
Affinity DataIC50:  0.0900nMAssay Description:Affinity for purified activated GPIIb/IIIa fibrinogen receptor in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50098971(3-({3-Benzyl-2-[(Z)-4-carbamimidoyl-benzoylimino]-...)
Affinity DataIC50:  0.0900nMAssay Description:Affinity for purified activated GPIIb/IIIa fibrinogen receptor in ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067216(CHEMBL129877 | {6-[4-(Imino-morpholin-4-yl-methyl)...)
Affinity DataIC50:  0.0980nMAssay Description:Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50287978((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50287969((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobilized integrin alpha IIb beta3More data for this Ligand-Target Pair
In DepthDetails Article
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083469((R)-3-(5-Chloro-thiophen-2-yl)-3-{[(R)-1-(3-piperi...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083490((R)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50:  0.100nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104596(3-{[3-(2-Piperidin-4-yl-vinyl)-5,6,7,8-tetrahydro-...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of thrombin-induced human gel-filtered platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50098967(3-({2-[(Z)-4-Carbamimidoyl-benzoylimino]-3-ethyl-4...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of immobilized HUVEC adhesion on fibronectinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067217(CHEMBL323649 | {(S)-6-[4-(Imino-morpholin-4-yl-met...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067228(CHEMBL131823 | [7-(4-Carbamimidoyl-benzoylamino)-1...)
Affinity DataIC50:  0.120nMAssay Description:Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083492((S)-3-(6-Methyl-pyridin-3-yl)-3-{[(R)-1-(3-piperid...)
Affinity DataIC50:  0.130nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067220(CHEMBL130405 | {7-[4-(N-Propylcarbamimidoyl)-benzo...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50098964(3-({3-Butyl-2-[(Z)-4-carbamimidoyl-benzoylimino]-4...)
Affinity DataIC50:  0.130nMAssay Description:Binding to [125I]- fibrinogen by washed platelet fibrinogen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067224(CHEMBL130437 | {6-[4-(N-Prop-2-ynylcarbamimidoyl)-...)
Affinity DataIC50:  0.130nMAssay Description:Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083453((S)-3-(6-Chloro-pyridin-3-yl)-3-{[(R)-1-(3-piperid...)
Affinity DataIC50:  0.140nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067218(CHEMBL130878 | {7-[4-(Imino-morpholin-4-yl-methyl)...)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104600((S)-3-{[(R)-1-(3-Piperidin-4-yl-propionyl)-piperid...)
Affinity DataIC50:  0.150nMAssay Description:Inhibition of human Biotinylated Fg binding to immobilized Alpha II beta-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067223(CHEMBL130892 | {7-[4-(N-Prop-2-ynylcarbamimidoyl)-...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123253((S)-3-{[5-(3-Guanidinomethyl-phenyl)-thiophene-2-c...)
Affinity DataIC50:  0.160nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alphaV-beta3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104598(2-Benzyloxycarbonylamino-3-{[(R)-1-(3-piperidin-4-...)
Affinity DataIC50:  0.170nMAssay Description:Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50346319((S)-3-(3-fluoro-4-(4-(1,4,5,6-tetrahydropyrimidin-...)
Affinity DataIC50:  0.180nMAssay Description:Antagonist activity at alpha2bbeta3 integrin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50497715(CHEMBL1180976)
Affinity DataIC50:  0.200nMAssay Description:Antagonist activity at alpha2bbeta3 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067227(CHEMBL128539 | {7-[4-(N-Furan-2-ylmethyl-carbamimi...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50104597((S)-3-{[3-((E)-2-Piperidin-4-yl-vinyl)-5,6,7,8-tet...)
Affinity DataIC50:  0.210nMAssay Description:Inhibition of biotinylated fibrinogen binding to immobilized integrin GPIIb/IIIaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083456((S)-3-(5-Bromo-pyridin-3-yl)-3-{[(R)-1-(3-piperidi...)
Affinity DataIC50:  0.210nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50346318((S)-3-(3-fluoro-4-(4-(1,4,5,6-tetrahydropyrimidin-...)
Affinity DataIC50:  0.210nMAssay Description:Antagonist activity at alpha2bbeta3 integrin receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50062810(3-{(S)-1-[2-(4-Carbamimidoyl-benzoylamino)-acetyl]...)
Affinity DataIC50:  0.210nMAssay Description:Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083479((R)-5-Phenyl-3-{[(R)-1-(3-piperidin-4-yl-propionyl...)
Affinity DataIC50:  0.220nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083455((S)-3-(5-Ethynyl-pyridin-3-yl)-3-{[(R)-1-(3-piperi...)
Affinity DataIC50:  0.240nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083496((R)-3-Benzo[1,3]dioxol-5-yl-3-({(R)-1-[3-(1-methyl...)
Affinity DataIC50:  0.240nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50058855((S)-2-Butoxycarbonylamino-3-{2-[(R)-3-(4-carbamimi...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of [125I]fibrinogen binding to purified platelet Fibrinogen ReceptorMore data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123252((S)-2-Benzenesulfonylamino-3-{[5-(2-guanidino-phen...)
Affinity DataIC50:  0.25nMAssay Description:Inhibition of fibrinogen binding to K562 cells expressing integrin alpha5-beta1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50058855((S)-2-Butoxycarbonylamino-3-{2-[(R)-3-(4-carbamimi...)
Affinity DataIC50:  0.25nMAssay Description:Inhbition of platelet aggregation in heparin treated human platelet rich plasma (PRP)More data for this Ligand-Target Pair
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50067230(CHEMBL131593 | {7-[4-(N-Allylcarbamimidoyl)-benzoy...)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of Fibronogen binding to Immobilized Human Fibrinogen Receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50083467((S)-5-Phenyl-3-{[(R)-1-(3-piperidin-4-yl-propionyl...)
Affinity DataIC50:  0.290nMAssay Description:In vitro inhibition of biotinylated fibrinogen binding to immobolized fibrinogen receptor.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50062797(3-{(S)-1-[2-(4-Carbamimidoyl-benzoylamino)-acetyl]...)
Affinity DataIC50:  0.290nMAssay Description:Ability to inhibit binding of biotin-labeled human fibrinogen to immobilized fibrinogen receptor purified from human erythroleukemia(HEL) cells.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-IIb/beta-3(Homo sapiens (Human))
Shire Biochem

Curated by ChEMBL
LigandPNGBDBM50123248((S)-2-Benzenesulfonylamino-3-{[5-(3-guanidinomethy...)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at alpha2bbeta3 integrin receptor (unknown origin) by cell-free ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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