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Compile Data Set for Download or QSAR

Found 20 hits Enz. Inhib. hit(s) with all data for entry = 9934   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Stimulator of interferon genes protein [138-378]


(Mus musculus (Mouse))
BDBM501204
PNG
(US11021511, Compound 4)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C4OCC3(COP(O)(=O)OC1C2CO)OC4n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<2n/an/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501364
PNG
(US11021511, Compound 6c)
Show SMILES CO[C@@H]1[C@H]2CO[P@@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [138-378]


(Mus musculus (Mouse))
BDBM501363
PNG
(US11021511, Compound 6b)
Show SMILES CO[C@@H]1[C@H]2CO[P@@](S)(=O)O[C@@H]3[C@@H](CO[P@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501362
PNG
(US11021511, Compound 6a)
Show SMILES CO[C@@H]1[C@H]2CO[P@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501361
PNG
(US11021511, Compound 5)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C(COP(O)(=O)OC1C2CO)OC(C3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501363
PNG
(US11021511, Compound 6b)
Show SMILES CO[C@@H]1[C@H]2CO[P@@](S)(=O)O[C@@H]3[C@@H](CO[P@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501204
PNG
(US11021511, Compound 4)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C4OCC3(COP(O)(=O)OC1C2CO)OC4n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [138-378]


(Mus musculus (Mouse))
BDBM501364
PNG
(US11021511, Compound 6c)
Show SMILES CO[C@@H]1[C@H]2CO[P@@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a<10n/an/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [138-378]


(Mus musculus (Mouse))
BDBM501361
PNG
(US11021511, Compound 5)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C(COP(O)(=O)OC1C2CO)OC(C3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 16n/an/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501193
PNG
(US11021511, Compound 1)
Show SMILES CC1(O)C(OC2COP(O)(=O)OC3C(O)C(COP(O)(=O)OC12)OC3n1cnc2c1nc(N)[nH]c2=O)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 5.45E+4n/an/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
The human STING SPA binding assay measures displacement of tritium labeled 2′,3′cGAMP (cyclic (guanosine-(2′→5′)-monoph...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501364
PNG
(US11021511, Compound 6c)
Show SMILES CO[C@@H]1[C@H]2CO[P@@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.70n/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501364
PNG
(US11021511, Compound 6c)
Show SMILES CO[C@@H]1[C@H]2CO[P@@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 60n/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501363
PNG
(US11021511, Compound 6b)
Show SMILES CO[C@@H]1[C@H]2CO[P@@](S)(=O)O[C@@H]3[C@@H](CO[P@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/a 1.70n/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501363
PNG
(US11021511, Compound 6b)
Show SMILES CO[C@@H]1[C@H]2CO[P@@](S)(=O)O[C@@H]3[C@@H](CO[P@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 107n/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501362
PNG
(US11021511, Compound 6a)
Show SMILES CO[C@@H]1[C@H]2CO[P@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/a 6n/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501362
PNG
(US11021511, Compound 6a)
Show SMILES CO[C@@H]1[C@H]2CO[P@](S)(=O)O[C@@H]3[C@@H](CO[P@@](S)(=O)O[C@H]1[C@@H](O2)n1cnc2c1nc(N)[nH]c2=O)O[C@H]([C@@H]3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 53n/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501361
PNG
(US11021511, Compound 5)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C(COP(O)(=O)OC1C2CO)OC(C3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/a<10n/an/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
Compounds were analyzed on an S200 biacore SPR instrument (GE Healthcare). E. coli produced truncated STING protein was immobilized on a series S str...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501361
PNG
(US11021511, Compound 5)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C(COP(O)(=O)OC1C2CO)OC(C3F)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 210n/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501204
PNG
(US11021511, Compound 4)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)C1OC2COP(O)(=O)OC3C4OCC3(COP(O)(=O)OC1C2CO)OC4n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 19n/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair
Stimulator of interferon genes protein [139-379,H232R]


(Homo sapiens (Human))
BDBM501193
PNG
(US11021511, Compound 1)
Show SMILES CC1(O)C(OC2COP(O)(=O)OC3C(O)C(COP(O)(=O)OC12)OC3n1cnc2c1nc(N)[nH]c2=O)n1cnc2c(N)ncnc12
PDB
MMDB

GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/an/an/a 1.81E+3n/an/an/an/a



Janssen Biotech, Inc.

US Patent


Assay Description
Agonism of the human STING pathway is assessed in THP1-ISG cells (Invivogen, cat #thp-isg) derived from human THP1 monocyte cell line by stable integ...


US Patent US11021511 (2021)

More data for this
Ligand-Target Pair