Compile Data Set for Download or QSAR
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Found 27 Enz. Inhib. hit(s) with all data for entry = 50037098
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103430(6-Amino-2-(3-(1H-indol-3-yl)-2-{[4-(2-oxo-2,3-dihy...)
Affinity DataKi:  0.0100nMAssay Description:Binding affinity towards Somatostatin receptor type 2 (hsst2)More data for this Ligand-Target Pair
TargetSomatostatin receptor type 3(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103430(6-Amino-2-(3-(1H-indol-3-yl)-2-{[4-(2-oxo-2,3-dihy...)
Affinity DataKi:  31nMAssay Description:Binding affinity towards Somatostatin receptor type 3 (hsst3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103430(6-Amino-2-(3-(1H-indol-3-yl)-2-{[4-(2-oxo-2,3-dihy...)
Affinity DataKi:  81nMAssay Description:Binding affinity towards Somatostatin receptor type 4 (hsst4)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 5(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103430(6-Amino-2-(3-(1H-indol-3-yl)-2-{[4-(2-oxo-2,3-dihy...)
Affinity DataKi:  163nMAssay Description:Binding affinity towards Somatostatin receptor type 5 (hsst5)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast cell carboxypeptidase A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121929((phenylmethyl)butanedioic acid | 2-benzylbutanedio...)
Affinity DataKi:  450nMAssay Description:The compound was evaluated for the inhibition of Carboxypeptidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50103430(6-Amino-2-(3-(1H-indol-3-yl)-2-{[4-(2-oxo-2,3-dihy...)
Affinity DataKi:  2.39E+3nMAssay Description:Binding affinity towards Somatostatin receptor type 1 (hsst1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast cell carboxypeptidase A(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121917(2-Benzyl-pentanedioic acid | CHEMBL153232)
Affinity DataKi:  5.00E+3nMAssay Description:The compound was evaluated for the inhibition of Carboxypeptidase AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121928(2-(1-Formyl-2-phenyl-ethylamino)-4-phenyl-butyric ...)
Affinity DataKi:  5.00E+4nMAssay Description:Inhibitory activity against Angiotensin I converting enzyme (ACE) in venom of Bothrops jararacaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(RAT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005463((R)-1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-...)
Affinity DataIC50:  0.0800nMAssay Description:Concentration required for 50% inhibition of Cholecystokinin type A receptor in rat pancreatic tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50049478(1-{[(2R)-3-(benzyloxy)-1-{1-methanesulfonyl-1,2-di...)
Affinity DataIC50:  0.510nMAssay Description:Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) receptor expressed in COS-7 cellsMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121930(6-(1-Carboxy-3-phenyl-propylamino)-5-oxo-octahydro...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121927(CHEMBL437713 | Glu-Ser-OctSer-phe-Leu-Ser-Pro-Glu-...)
Affinity DataIC50:  0.710nMAssay Description:Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50367879(LISINOPRIL)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50367254(ENALAPRILAT)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50:  2nMAssay Description:Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGrowth hormone secretagogue receptor type 1(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121916(CHEMBL433540 | His-D-Trp-Ala-Trp-D-Phe-Lys-NH2)
Affinity DataIC50:  13.2nMAssay Description:Ability to displace [125I]ghrelin from cloned human Growth hormone secretagogue receptor type I (GSH1a) expressed in COS-7 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50011367(1-(3-Mercapto-2-methyl-propionyl)-pyrrolidine-2-ca...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedMMDB

TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121926(1-[2-(1-Carboxy-ethylamino)-propionyl]-pyrrolidine...)
Affinity DataIC50:  90nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005463((R)-1H-Indole-2-carboxylic acid (1-methyl-2-oxo-5-...)
Affinity DataIC50:  245nMAssay Description:Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCholecystokinin receptor type A(RAT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81962(S-L-365,260)
Affinity DataIC50:  280nMAssay Description:Concentration required for 50% inhibition of Cholecystokinin type A receptor in rat pancreatic tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50017129((S)-1-((S)-2-((R)-1-ethoxy-1-oxo-4-phenylbutan-2-y...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCholecystokinin receptor type A(RAT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121922(7-(9-Hydroxy-2-isobutyl-2-methyl-3-oxo-2,3,9,9a-te...)
Affinity DataIC50:  1.40E+3nMAssay Description:Concentration required for 50% inhibition of Cholecystokinin type A receptor in rat pancreatic tissueMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50044234(1-[2-(1-Carboxy-ethylamino)-propionyl]-pyrrolidine...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027357(1-(4-Carboxy-2-methyl-butyryl)-pyrrolidine-2-carbo...)
Affinity DataIC50:  4.90E+3nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50027757(1-(4-Carboxy-butyryl)-pyrrolidine-2-carboxylic aci...)
Affinity DataIC50:  7.00E+4nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121922(7-(9-Hydroxy-2-isobutyl-2-methyl-3-oxo-2,3,9,9a-te...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of Cholecystokinin type B receptor induced guinea pig gall bladder contractions when given intravenouslyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50121925(1-(4-Carboxy-pentanoyl)-pyrrolidine-2-carboxylic a...)
Affinity DataIC50:  2.60E+5nMAssay Description:Inhibition of Angiotensin I converting enzyme (ACE) in Bothrops jararaca venomMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed