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Report error Found 10 Enz. Inhib. hit(s) with all data for entry = 10093
TargetReplicase polyprotein 1ab(2019-nCoV)
Shionogi

LigandPNGBDBM513874(bioRxiv20220126.477782, S-217622 | bioRxiv20220126...)
Affinity DataIC50:  13nMAssay Description:The 3CL protease inhibition assay was conducted in 384-well plates (Corning 3702). The substance solution (10 mM dimethyl sulfoxide [DMSO] solution) ...More data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)
Shionogi

LigandPNGBDBM513873(bioRxiv20220126.477782, Screening Hit 2)
Affinity DataIC50:  96nMAssay Description:The 3CL protease inhibition assay was conducted in 384-well plates (Corning 3702). The substance solution (10 mM dimethyl sulfoxide [DMSO] solution) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)
Shionogi

LigandPNGBDBM513872(bioRxiv20220126.477782, Screening Hit 1)
Affinity DataIC50:  8.60E+3nMAssay Description:The 3CL protease inhibition assay was conducted in 384-well plates (Corning 3702). The substance solution (10 mM dimethyl sulfoxide [DMSO] solution) ...More data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(Human SARS coronavirus (SARS-CoV) (Severe acute re...)
Shionogi

LigandPNGBDBM513874(bioRxiv20220126.477782, S-217622 | bioRxiv20220126...)
Affinity DataEC50:  210nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(Middle East respiratory syndrome-related coronavir...)
Shionogi

LigandPNGBDBM513874(bioRxiv20220126.477782, S-217622 | bioRxiv20220126...)
Affinity DataEC50:  1.40E+3nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-229E)
Shionogi

LigandPNGBDBM513874(bioRxiv20220126.477782, S-217622 | bioRxiv20220126...)
Affinity DataEC50:  5.50E+3nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)
Shionogi

LigandPNGBDBM513874(bioRxiv20220126.477782, S-217622 | bioRxiv20220126...)
Affinity DataEC50:  370nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(HCoV-OC43)
Shionogi

LigandPNGBDBM513874(bioRxiv20220126.477782, S-217622 | bioRxiv20220126...)
Affinity DataEC50:  74nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
In DepthDetails
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Shionogi

LigandPNGBDBM513873(bioRxiv20220126.477782, Screening Hit 2)
Affinity DataEC50:  1.25E+4nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetTransmembrane protease serine 2(Homo sapiens (Human))
Shionogi

LigandPNGBDBM513874(bioRxiv20220126.477782, S-217622 | bioRxiv20220126...)
Affinity DataEC50:  370nMAssay Description:Antiviral activity against SARS-CoV-2, SARS-CoV, MERS-CoV and HCoV-229E was assessed by monitoring cell viability; that against HCoV-OC43 was assesse...More data for this Ligand-Target Pair
In DepthDetails