Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with all data for entry = 50033760
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50350791(LEVOBUPIVACAINE HYDROCHLORIDE)
Show SMILES CCCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)/t16-/m0/s1
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp techniqu...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50350791(LEVOBUPIVACAINE HYDROCHLORIDE)
Show SMILES CCCCN1CCCC[C@H]1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)/t16-/m0/s1
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of wild-type human ERG channel expressed in CHO cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of wild-type human ERG channel expressed in CHO cells by whole-cell patch clamp techniqueMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50350790(BUPIVACAINE HYDROCHLORIDE | Bupivacaine | SAMPL3, ...)
Show SMILES CCCCN1CCCCC1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)
Affinity DataIC50: 3.20E+4nMAssay Description:Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp techniqu...More data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Geneva

Curated by ChEMBL
LigandPNGBDBM50350789(BUPIVACAINE | CHEMBL189827)
Show SMILES CCCCN1CCCC[C@@H]1C(=O)Nc1c(C)cccc1C
Show InChI InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)/t16-/m1/s1
Affinity DataIC50: 8.40E+4nMAssay Description:Inhibition of wild-type human ERG channel expressed in HEK293 cells assessed as blockade of potassium tail current by whole-cell patch clamp techniqu...More data for this Ligand-Target Pair