Compile Data Set for Download or QSAR
Found 5 Enz. Inhib. hit(s) with all data for entry = 50035138
Target4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5(Homo sapiens (Human))
Technische Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50101904(CHEMBL52741 | GDP-Azasugar analogue)
Show SMILES C[C@@H]1[NH2+][C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c2nc([NH3+])[nH]c3=O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C16H26N6O13P2/c1-5-9(23)10(24)6(19-5)2-32-36(28,29)35-37(30,31)33-3-7-11(25)12(26)15(34-7)22-4-18-8-13(22)20-16(17)21-14(8)27/h4-7,9-12,15,19,23-26H,2-3H2,1H3,(H,28,29)(H,30,31)(H3,17,20,21,27)/t5-,6+,7+,9+,10+,11+,12+,15+/m0/s1
Affinity DataIC50: 4.50E+4nMAssay Description:Inhibition of GnRH-stimulated luteinizing hormone (LH) release in rat pituitary cellsMore data for this Ligand-Target Pair
Target4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5(Homo sapiens (Human))
Technische Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM92459(CHEMBL384759 | GDP | Guanosine Diphosphate)
Show SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Show InChI InChI=1S/C10H15N5O11P2/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(25-9)1-24-28(22,23)26-27(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
Affinity DataIC50: 6.70E+4nMAssay Description:Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamineMore data for this Ligand-Target Pair
Target4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5(Homo sapiens (Human))
Technische Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50101904(CHEMBL52741 | GDP-Azasugar analogue)
Show SMILES C[C@@H]1[NH2+][C@H](COP([O-])(=O)OP([O-])(=O)OC[C@H]2O[C@H]([C@H](O)[C@@H]2O)n2cnc3c2nc([NH3+])[nH]c3=O)[C@@H](O)[C@@H]1O
Show InChI InChI=1S/C16H26N6O13P2/c1-5-9(23)10(24)6(19-5)2-32-36(28,29)35-37(30,31)33-3-7-11(25)12(26)15(34-7)22-4-18-8-13(22)20-16(17)21-14(8)27/h4-7,9-12,15,19,23-26H,2-3H2,1H3,(H,28,29)(H,30,31)(H3,17,20,21,27)/t5-,6+,7+,9+,10+,11+,12+,15+/m0/s1
Affinity DataIC50: 8.20E+4nMAssay Description:Inhibitory activity against fucosyltransferase (FucT V) in the presence of 10 mM fucosyl acceptor N-acetyllactosamineMore data for this Ligand-Target Pair
Target4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5(Homo sapiens (Human))
Technische Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50101907(({[(2R,3S,4R,5R)-5-(2-azaniumyl-6-hydroxy-9H-purin...)
Show SMILES CP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c1nc([NH3+])[nH]c2=O
Show InChI InChI=1S/C11H17N5O10P2/c1-27(20,21)26-28(22,23)24-2-4-6(17)7(18)10(25-4)16-3-13-5-8(16)14-11(12)15-9(5)19/h3-4,6-7,10,17-18H,2H2,1H3,(H,20,21)(H,22,23)(H3,12,14,15,19)/p-1/t4-,6-,7-,10-/m1/s1
Affinity DataIC50: 5.00E+5nMAssay Description:Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamineMore data for this Ligand-Target Pair
Target4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase FUT5(Homo sapiens (Human))
Technische Universit£t Berlin

Curated by ChEMBL
LigandPNGBDBM50101906(CHEMBL53188 | GDP-Azasugar analogue)
Show SMILES [NH3+]CCOP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)n1cnc2c1nc([NH3+])[nH]c2=O
Show InChI InChI=1S/C12H20N6O11P2/c13-1-2-26-30(22,23)29-31(24,25)27-3-5-7(19)8(20)11(28-5)18-4-15-6-9(18)16-12(14)17-10(6)21/h4-5,7-8,11,19-20H,1-3,13H2,(H,22,23)(H,24,25)(H3,14,16,17,21)/t5-,7-,8-,11-/m1/s1
Affinity DataIC50: 1.00E+6nMAssay Description:Inhibitory activity against fucosyltransferase (FucT V) in the presence of fucosyl acceptor N-acetyllactosamineMore data for this Ligand-Target Pair