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Found 417 Enz. Inhib. hit(s) with Target = 'Isoform 3 of cAMP-specific 3',5'-cyclic phosphodiesterase 4D'
LigandPNGBDBM194401(US9200016, 83 | US9902710, Compound 83)
Affinity DataIC50:  439nMpH: 7.4 T: 2°CAssay Description:The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM194487(US9200016, 169 | US9902710, Compound 169)
Affinity DataIC50:  194nMpH: 7.4 T: 2°CAssay Description:The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM194480(US9200016, 162 | US9902710, Compound 162)
Affinity DataIC50:  232nMpH: 7.4 T: 2°CAssay Description:The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM194411(US9200016, 93 | US9902710, Compound 93)
Affinity DataIC50:  398nMpH: 7.4 T: 2°CAssay Description:The phosphodiesterase assay was developed using the LANCE cAMP kit (PerkinElmer). The assay buffer contained HBSS with 5 mM HEPES, 0.1% BSA, and 1....More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM285528(Azetidin-1-yl[3-(4-chlorophenyl)imidazo[1,2-b]pyri...)
Affinity DataIC50:  130nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285528(Azetidin-1-yl[3-(4-chlorophenyl)imidazo[1,2-b]pyri...)
Affinity DataIC50:  1.03E+4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285529(3-(4-Chlorophenyl)-N-cyclopropylimidazo[1,2-b]pyri...)
Affinity DataIC50:  27.9nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285529(3-(4-Chlorophenyl)-N-cyclopropylimidazo[1,2-b]pyri...)
Affinity DataIC50:  4.34E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285530(Azetidin-1-yl[3-(3,5-difluoro-4-methoxyphenyl)imid...)
Affinity DataIC50:  51.9nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285530(Azetidin-1-yl[3-(3,5-difluoro-4-methoxyphenyl)imid...)
Affinity DataIC50:  2.41E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285531(N-Cyclopropyl-3-(2-methoxypyrimidin-5-yl)imidazo[1...)
Affinity DataIC50:  561nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285531(N-Cyclopropyl-3-(2-methoxypyrimidin-5-yl)imidazo[1...)
Affinity DataIC50: >2.71E+4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285532(3-(6-Cyanopyridin-3-yl)-N-cyclopropylimidazo[1,2-b...)
Affinity DataIC50:  208nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285532(3-(6-Cyanopyridin-3-yl)-N-cyclopropylimidazo[1,2-b...)
Affinity DataIC50: >2.66E+4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  326nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285533(N-Cyclopropyl-3-([1,2,4]triazolo[1,5-a]pyridin-6-y...)
Affinity DataIC50:  4.89E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285534(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Affinity DataIC50:  2.35nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285534(3-(4-Chloro-3-fluorophenyl)-N-(1-methyl-1H-pyrazol...)
Affinity DataIC50:  34.5nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285535(Azetidin-1-yl[3-(pyrazolo[1,5-a]pyridin-6-yl)imida...)
Affinity DataIC50:  64.9nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285535(Azetidin-1-yl[3-(pyrazolo[1,5-a]pyridin-6-yl)imida...)
Affinity DataIC50:  5.44E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285536(3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimida...)
Affinity DataIC50:  40.9nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285536(3-(4-Chloro-2,5-difluorophenyl)-N-cyclopropylimida...)
Affinity DataIC50:  1.49E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285537(3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...)
Affinity DataIC50:  6.84nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285537(3-(4-chloro-3-fluoro-phenyl)-N-cyclopropyl-imidazo...)
Affinity DataIC50:  590nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285538(N-cyclopropyl-3-(3,4-di-chlorophenyl)imidazo[1,2-b...)
Affinity DataIC50:  334nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285539(3-(4-chloro-2-methyl-phenyl)-N-cyclopropyl-imidazo...)
Affinity DataIC50:  89.6nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285539(3-(4-chloro-2-methyl-phenyl)-N-cyclopropyl-imidazo...)
Affinity DataIC50:  5.22E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285540(US10077269, Example 13 | US10669279, Example 13 | ...)
Affinity DataIC50:  17.3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285540(US10077269, Example 13 | US10669279, Example 13 | ...)
Affinity DataIC50:  669nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285541(3-(5-chloropyridin-3-yl)-N-cyclopropylimidazo[1,2-...)
Affinity DataIC50:  108nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285541(3-(5-chloropyridin-3-yl)-N-cyclopropylimidazo[1,2-...)
Affinity DataIC50: >8.01E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285542(US10077269, Example 15 | US10669279, Example 15 | ...)
Affinity DataIC50:  421nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285542(US10077269, Example 15 | US10669279, Example 15 | ...)
Affinity DataIC50: >2.37E+4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285543(US10077269, Example 16 | US10669279, Example 16 | ...)
Affinity DataIC50: >2.75E+4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285544(3-(4-cyano-2-fluoro-5-methylphenyl)-N-cyclopropyl-...)
Affinity DataIC50:  216nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285544(3-(4-cyano-2-fluoro-5-methylphenyl)-N-cyclopropyl-...)
Affinity DataIC50: >1.82E+4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285545(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Affinity DataIC50:  147nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285545(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Affinity DataIC50:  8.20E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285546(3-(4-cyano-5-fluoro-2-methylphenyl)-N-cyclo-propyl...)
Affinity DataIC50:  98.4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285546(3-(4-cyano-5-fluoro-2-methylphenyl)-N-cyclo-propyl...)
Affinity DataIC50:  645nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285547(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Affinity DataIC50:  74.8nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285547(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Affinity DataIC50:  490nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285548(3-(4-chloro-3-fluorophenyl)-N-cyclopropyl-N-methyl...)
Affinity DataIC50:  170nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285548(3-(4-chloro-3-fluorophenyl)-N-cyclopropyl-N-methyl...)
Affinity DataIC50: >1.23E+4nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285549(N-cyclopropyl-3-(pyrazolo[1,5-a]pyridin-6-yl)imida...)
Affinity DataIC50:  71.2nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285549(N-cyclopropyl-3-(pyrazolo[1,5-a]pyridin-6-yl)imida...)
Affinity DataIC50:  1.89E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285550(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Affinity DataIC50:  45.8nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285550(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Affinity DataIC50:  4.13E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285551(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Affinity DataIC50:  59.7nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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LigandPNGBDBM285551(4-[2-(azetidin-1-ylcarbonyl)imidazo[1,2-b]pyridazi...)
Affinity DataIC50: >2.15E+3nMAssay Description:The PDE4A3, PDE4B1, PDE4C1 and PDE4D3 assays use the Scintillation Proximity Assay (SPA) technology to measure the inhibition of human recombinant PD...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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