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Found 1959 Enz. Inhib. hit(s) with Target = 'MAP kinase-activated protein kinase 2'
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30309(Pyrrolo-pyrimidone, 2)
Affinity DataIC50:  1.30E+3nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30195(Pyrrolopyridine, 26)
Affinity DataIC50:  71nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30311(Pyrrolo-pyrimidone, 4)
Affinity DataIC50:  550nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30312(Pyrrolo-pyrimidone, 5)
Affinity DataIC50:  5.20E+3nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30313(Pyrrolo-pyrimidone, 6)
Affinity DataIC50:  1.45E+3nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30314(Pyrrolo-pyrimidone, 7)
Affinity DataIC50:  190nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30315(Pyrrolo-pyrimidone, 8)
Affinity DataIC50:  170nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30316(Pyrrolo-pyrimidone, 9)
Affinity DataIC50:  200nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30317(Pyrrolo-pyrimidone, 10)
Affinity DataIC50:  290nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30318(Pyrrolo-pyrimidone, 11)
Affinity DataIC50:  1.70E+3nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30319(Pyrrolo-pyrimidone, 12)
Affinity DataIC50:  350nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30320(Pyrrolo-pyrimidone, 13)
Affinity DataIC50:  1.26E+3nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30321(Pyrrolo-pyrimidone, 14)
Affinity DataIC50:  340nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30322(Pyrrolo-pyrimidone, 15)
Affinity DataIC50:  42nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30323(Pyrrolo-pyrimidone, 16)
Affinity DataIC50:  51nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30324(Pyrrolo-pyrimidone, 17)
Affinity DataIC50:  82nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30325(Pyrrolo-pyrimidone, 18)
Affinity DataIC50:  150nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM175242(US11844801, Compound (M)-I | US9115089, 49)
Affinity DataIC50:  21nMpH: 7.5Assay Description:The ability of compounds to inhibit activated phospho-p38alpha is evaluated using a p38alpha /MK2 and a p38alpha /PRAK cascade assay format. The kina...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM236557(US9365572, 5)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Agents: 1-fold kinase buffer without MnCl2: 50 mM HEPES, pH 7.5, 0.0015% Brij-35, 10 mM MgCl2, 2 mM DTT. 1-fold kinase buffer with MnCl2: 50 mM HEPES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM27344(2-(pyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,2-c]pyri...)
Affinity DataIC50:  171nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM27388(2-(2-chloropyridin-4-yl)-1H,4H,5H,6H,7H-pyrrolo[3,...)
Affinity DataIC50:  608nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30178(Pyrrolopyridine, 9)
Affinity DataIC50:  66nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30179(Pyrrolopyridine, 10)
Affinity DataIC50:  56nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30180(Pyrrolopyridine, 11)
Affinity DataIC50:  48nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30181(Pyrrolopyridine, 12)
Affinity DataIC50:  83nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30182(Pyrrolopyridine, 13)
Affinity DataIC50:  76nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30183(Pyrrolopyridine, 14)
Affinity DataIC50:  52nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30184(Pyrrolopyridine, 15)
Affinity DataIC50:  30nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30185(CHEMBL226403 | Pyrrolopyridine, 16)
Affinity DataIC50:  8.5nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30186(Pyrrolopyridine, 17)
Affinity DataIC50:  410nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30187(Pyrrolopyridine, 18)
Affinity DataIC50:  25nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30188(Pyrrolopyridine, 19)
Affinity DataIC50:  21nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30189(Pyrrolopyridine, 20)
Affinity DataIC50:  606nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30190(Pyrrolopyridine, 21)
Affinity DataIC50:  37nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30191(Pyrrolopyridine, 22)
Affinity DataIC50:  32nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30192(Pyrrolopyridine, 23)
Affinity DataIC50:  126nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30193(Pyrrolopyridine, 24)
Affinity DataIC50:  30nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30194(Pyrrolopyridine, 25)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:The phosphorylation of HSP27 peptide by MAPKAPK2 was measured using an anion exchange resin capture assay method. The reaction was carried out in rea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2(Homo sapiens (Human))
Novartis

LigandPNGBDBM30310(Pyrrolo-pyrimidone, 3)
Affinity DataIC50:  1.23E+3nMpH: 7.5 T: 2°CAssay Description:For MK2 inhibition, reactions contained compound or vehicle control, hsp27 peptide substrate and activated MK2 mix containing ATP. After incubation, ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30290(indole-based 6-membered lactam, 4c)
Affinity DataIC50:  550nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30291(indole-based 6-membered lactam, 4e)
Affinity DataIC50:  4.00E+3nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30292(indole-based 6-membered lactam, 4f)
Affinity DataIC50:  580nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30293(indole-based 6-membered lactam, 4g)
Affinity DataIC50:  3.00E+3nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30294(indole-based 6-membered lactam, 4h)
Affinity DataIC50:  4.00E+3nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30295(indole-based 6-membered lactam, 4i)
Affinity DataIC50: >1.00E+4nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30296(indole-based 6-membered lactam, 4j)
Affinity DataIC50: >1.00E+4nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30297(indole-based 6-membered lactam, 4k)
Affinity DataIC50:  6.90E+3nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30207(carboline analog, 20)
Affinity DataIC50: >4.00E+4nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30208(carboline analog, 21)
Affinity DataIC50: >4.00E+4nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 2 [41-364](Homo sapiens (Human))
Boehringer Ingelheim Pharmaceuticals

LigandPNGBDBM30209(carboline analog, 22)
Affinity DataIC50: >4.00E+4nMpH: 7.6 T: 2°CAssay Description:Diluted compounds and activated GST-MK2 were incubated in neutravidin coated plates (Pierce) in reaction buffer containing biotinylated GST-LSP1 and ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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