Compile Data Set for Download or QSAR
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Found 362 Enz. Inhib. hit(s) with Target = 'Mitogen-activated protein kinase kinase kinase 8'
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29915(substituted 6-aminoquinoline-3-carbonitrile, 26)
Affinity DataIC50:  13nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29916(substituted 6-aminoquinoline-3-carbonitrile, 27)
Affinity DataIC50:  22nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29917(substituted 6-aminoquinoline-3-carbonitrile, 28)
Affinity DataIC50:  28nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29918(substituted 6-aminoquinoline-3-carbonitrile, 29)
Affinity DataIC50:  8nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21896(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50:  20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21897(4-[(3-chloro-4-fluorophenyl)amino]-8-fluoro-6-[(1H...)
Affinity DataIC50:  20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21898(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H...)
Affinity DataIC50:  20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21899(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50:  10nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21900(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50:  160nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21901(4-[(3-chloro-4-fluorophenyl)amino]-8-hydroxy-6-[(1...)
Affinity DataIC50:  1.13E+4nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21902(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50:  130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21903(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50:  20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21904(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50:  190nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21905(4-[(3-chloro-4-fluorophenyl)amino]-3-cyano-6-[(1H-...)
Affinity DataIC50:  130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21906(4-[(3-chloro-4-fluorophenyl)amino]-8-acetyl-6-[(1H...)
Affinity DataIC50:  23nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21907(4-[(3-chloro-4-fluorophenyl)amino]-8-(2,3-dihydrox...)
Affinity DataIC50:  910nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21908(4-[(3-chloro-4-fluorophenyl)amino]-8-(2,3-dihydrox...)
Affinity DataIC50:  830nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21909(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[2-...)
Affinity DataIC50:  130nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21910(Cyanoquinoline, 23 | N-{8-bromo-4-[(3-chloro-4-flu...)
Affinity DataIC50: >5.00E+3nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21911(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1...)
Affinity DataIC50:  290nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21912(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1-...)
Affinity DataIC50:  98nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21913(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1-...)
Affinity DataIC50:  250nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21914(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({im...)
Affinity DataIC50:  280nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21915(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(py...)
Affinity DataIC50:  16nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21916(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[5...)
Affinity DataIC50: >3.00E+3nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21917(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[({5...)
Affinity DataIC50:  500nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21918(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(6...)
Affinity DataIC50:  170nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21919(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-({[6...)
Affinity DataIC50:  350nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21920(2-[({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3...)
Affinity DataIC50:  18nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21921(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2,3...)
Affinity DataIC50:  590nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21922(8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-6-[(2H...)
Affinity DataIC50:  2nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21923(2-({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3-...)
Affinity DataIC50:  200nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21924(2-({8-chloro-4-[(3-chloro-4-fluorophenyl)amino]-3-...)
Affinity DataIC50:  110nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21925(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50:  18nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues was detected by an ELISA. IC50 calculati...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29896(1,7-naphthyridine-3-carbonitrile, 1 | CHEMBL197538)
Affinity DataIC50:  1.20E+3nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21896(4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-imidazol...)
Affinity DataIC50:  19nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21933(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-{[(1-...)
Affinity DataIC50:  30nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29897(substituted 6-aminoquinoline-3-carbonitrile, 7)
Affinity DataIC50:  40nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM21925(8-bromo-4-[(3-chloro-4-fluorophenyl)amino]-6-[(1H-...)
Affinity DataIC50:  18nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29898(substituted 6-aminoquinoline-3-carbonitrile, 9)
Affinity DataIC50:  170nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29899(substituted 6-aminoquinoline-3-carbonitrile, 10)
Affinity DataIC50:  120nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29900(substituted 6-aminoquinoline-3-carbonitrile, 11)
Affinity DataIC50:  140nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29901(substituted 6-aminoquinoline-3-carbonitrile, 12)
Affinity DataIC50:  9.60nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29902(substituted 6-aminoquinoline-3-carbonitrile, 13)
Affinity DataIC50:  40nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29903(substituted 6-aminoquinoline-3-carbonitrile, 14)
Affinity DataIC50:  10nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29904(substituted 6-aminoquinoline-3-carbonitrile, 15)
Affinity DataIC50:  61nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29905(substituted 6-aminoquinoline-3-carbonitrile, 16)
Affinity DataIC50:  4.00E+4nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29906(substituted 6-aminoquinoline-3-carbonitrile, 17)
Affinity DataIC50:  7nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29907(substituted 6-aminoquinoline-3-carbonitrile, 18)
Affinity DataIC50:  23nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM29908(substituted 6-aminoquinoline-3-carbonitrile, 19)
Affinity DataIC50:  20nMpH: 7.2 T: 2°CAssay Description:Tpl2/Cot activity was directly assayed using GST-MEK1 as a substrate. The phosphorylation on serine residues 217 and 221 of GST-MEK1 was detected by ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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