Compile Data Set for Download or QSAR
maximum 50k data
Found 6 Enz. Inhib. hit(s) with all data for entry = 816
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM50166893(2-(3,4-Dimethoxy-benzyl)-7-[(R)-1-((R)-1-hydroxy-e...)
Affinity DataIC50:  1nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292716(1-(2-Chloro-5-(cyclobutylmethoxy)phenyl)-8-methoxy...)
Affinity DataIC50:  5.90nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292715(1-(5-Butoxy-2-chlorophenyl)-8-methoxy-3-methyl-1H-...)
Affinity DataIC50:  9.40nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292713(1-(5-Butoxy-2-chlorophenyl)-8-chloro-3-methyl-1H-p...)
Affinity DataIC50:  12nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292714(1-(5-Butoxy-2-chlorophenyl)-3-methyl-1H-pyrazolo[4...)
Affinity DataIC50:  28nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Intra-Cellular Therapies

US Patent
LigandPNGBDBM292712(8-Chloro-1-(2,5-dichlorophenyl)-3-methyl-1H-pyrazo...)
Affinity DataIC50:  73nMpH: 7.2 T: 2°CAssay Description:Assay: PDE2A is assayed with FL-cAMP as substrate. An enzyme titration is first performed to determine the working concentration of PDE. The concentr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent