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Found 5 Enz. Inhib. hit(s) with all data for entry = 8623
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664((R)-5-cyano-4-ethoxy-N-(1-(2-hydroxy-2-(4-methyl-1...)
Affinity DataIC50:  28nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...)
Affinity DataIC50:  40nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408664((R)-5-cyano-4-ethoxy-N-(1-(2-hydroxy-2-(4-methyl-1...)
Affinity DataIC50:  89nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetATP-sensitive inward rectifier potassium channel 1(Rattus norvegicus (Rat))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...)
Affinity DataIC50:  192nMAssay Description:The Inhibitory Activity of the Present Compounds on Human ROMK and Rat ROMK ChannelsThe method described hereafter was used for determining the inhib...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Jiangsu Hengrui Medicine

US Patent
LigandPNGBDBM408663((R)-5-cyano-N-(1-(2-hydroxy-2-(4-methyl-1-oxo-1,3-...)
Affinity DataIC50:  4.37E+4nMAssay Description:The method described hereafter is used for determining the inhibitory activity of the present compounds on hERG1. Materials and Instruments(1) FluxOR...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent