BindingDB logo
myBDB logout

Patent code US11040034

Compile Data Set for Download or QSAR

Found 272 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM287739
PNG
(US10085984, Example 117 | US11040034, Ex. No. 117)
Show SMILES Fc1cc2nc(-c3cnnc(OCC4CC4)c3)n(C3CC3)c2cc1F
Show InChI InChI=1S/C18H16F2N4O/c19-13-6-15-16(7-14(13)20)24(12-3-4-12)18(22-15)11-5-17(23-21-8-11)25-9-10-1-2-10/h5-8,10,12H,1-4,9H2
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287749
PNG
(US10085984, Example 127 | US11040034, Ex. No. 127)
Show SMILES FC(F)Oc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C15H10F4N4O/c16-9-4-11-12(5-10(9)17)23(8-1-2-8)14(21-11)7-3-13(22-20-6-7)24-15(18)19/h3-6,8,15H,1-2H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287758
PNG
(US10085984, Example 136 | US11040034, Ex. No. 136)
Show SMILES CC(F)c1cc(cnn1)-c1nc2ccc(cc2n1C1CC1)C#N
Show InChI InChI=1S/C17H14FN5/c1-10(18)15-7-12(9-20-22-15)17-21-14-5-2-11(8-19)6-16(14)23(17)13-3-4-13/h2,5-7,9-10,13H,3-4H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287626
PNG
(US10085984, Example 4 | US11040034, Ex. No. 4)
Show SMILES Fc1ccc2nc(-c3cnnc(C=C)c3)n(C3CC3)c2c1
Show InChI InChI=1S/C16H13FN4/c1-2-12-7-10(9-18-20-12)16-19-14-6-3-11(17)8-15(14)21(16)13-4-5-13/h2-3,6-9,13H,1,4-5H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287647
PNG
(US10085984, Example 25 | US11040034, Ex. No. 25)
Show SMILES CN(C)c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C16H15F2N5/c1-22(2)15-5-9(8-19-21-15)16-20-13-6-11(17)12(18)7-14(13)23(16)10-3-4-10/h5-8,10H,3-4H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287654
PNG
(US10085984, Example 32 | US11040034, Ex. No. 32)
Show SMILES Fc1cc2nc(-c3cnnc(NCC(F)(F)F)c3)n(C3CC3)c2cc1F
Show InChI InChI=1S/C16H12F5N5/c17-10-4-12-13(5-11(10)18)26(9-1-2-9)15(24-12)8-3-14(25-23-6-8)22-7-16(19,20)21/h3-6,9H,1-2,7H2,(H,22,25)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287663
PNG
(US10085984, Example 41 | US11040034, Ex. No. 41)
Show SMILES CCc1cc(cnn1)-c1nc2ccc(cc2n1CC)C#N
Show InChI InChI=1S/C16H15N5/c1-3-13-8-12(10-18-20-13)16-19-14-6-5-11(9-17)7-15(14)21(16)4-2/h5-8,10H,3-4H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287665
PNG
(US10085984, Example 43 | US11040034, Ex. No. 43)
Show SMILES Fc1cc2nc(-c3cnnc(OC4CCC4)c3)n(C3CC3)c2cc1F
Show InChI InChI=1S/C18H16F2N4O/c19-13-7-15-16(8-14(13)20)24(11-4-5-11)18(22-15)10-6-17(23-21-9-10)25-12-2-1-3-12/h6-9,11-12H,1-5H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287673
PNG
(US10085984, Example 51 | US11040034, Ex. No. 51)
Show SMILES CC(C)c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C17H16F2N4/c1-9(2)14-5-10(8-20-22-14)17-21-15-6-12(18)13(19)7-16(15)23(17)11-3-4-11/h5-9,11H,3-4H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM504374
PNG
(US11040034, Ex. No. 53)
Show SMILES CC(Oc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1)C(F)(F)F
Show InChI InChI=1S/C17H13F5N4O/c1-8(17(20,21)22)27-15-4-9(7-23-25-15)16-24-13-5-11(18)12(19)6-14(13)26(16)10-2-3-10/h4-8,10H,2-3H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM504375
PNG
(US11040034, Ex. No. 54)
Show SMILES Cc1cc(cnn1)-c1nc2ccc(nc2n1C1CC1)C#N
Show InChI InChI=1S/C15H12N6/c1-9-6-10(8-17-20-9)14-19-13-5-2-11(7-16)18-15(13)21(14)12-3-4-12/h2,5-6,8,12H,3-4H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287680
PNG
(US10085984, Example 58 | US11040034, Ex. No. 58)
Show SMILES CC(C)c1cnncc1-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C17H16F2N4/c1-9(2)11-7-20-21-8-12(11)17-22-15-5-13(18)14(19)6-16(15)23(17)10-3-4-10/h5-10H,3-4H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287684
PNG
(US10085984, Example 62 | US11040034, Ex. No. 62)
Show SMILES Fc1ccc(c(F)c1)-c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C20H12F4N4/c21-11-1-4-13(14(22)6-11)17-5-10(9-25-27-17)20-26-18-7-15(23)16(24)8-19(18)28(20)12-2-3-12/h1,4-9,12H,2-3H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287689
PNG
(US10085984, Example 67 | US11040034, Ex. No. 67)
Show SMILES CCn1c(nc2cc(F)c(F)cc12)-c1cnnc(c1)C(F)F
Show InChI InChI=1S/C14H10F4N4/c1-2-22-12-5-9(16)8(15)4-10(12)20-14(22)7-3-11(13(17)18)21-19-6-7/h3-6,13H,2H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287691
PNG
(US10085984, Example 69 | US11040034, Ex. No. 69)
Show SMILES CCn1c(nc2ccc(cc12)C#N)-c1cnnc(c1)C(F)F
Show InChI InChI=1S/C15H11F2N5/c1-2-22-13-5-9(7-18)3-4-11(13)20-15(22)10-6-12(14(16)17)21-19-8-10/h3-6,8,14H,2H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287705
PNG
(US10085984, Example 83 | US11040034, Ex. No. 83)
Show SMILES CCS(=O)c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C16H14F2N4OS/c1-2-24(23)15-5-9(8-19-21-15)16-20-13-6-11(17)12(18)7-14(13)22(16)10-3-4-10/h5-8,10H,2-4H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287709
PNG
(US10085984, Example 87 | US11040034, Ex. No. 87)
Show SMILES N#Cc1ccc2nc(-c3cnnc(c3)C3CC3)n(C3CC3)c2n1
Show InChI InChI=1S/C17H14N6/c18-8-12-3-6-14-17(20-12)23(13-4-5-13)16(21-14)11-7-15(10-1-2-10)22-19-9-11/h3,6-7,9-10,13H,1-2,4-5H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287713
PNG
(US10085984, Example 91 | US11040034, Ex. No. 91)
Show SMILES CC(NS(C)(=O)=O)c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C17H17F2N5O2S/c1-9(23-27(2,25)26)14-5-10(8-20-22-14)17-21-15-6-12(18)13(19)7-16(15)24(17)11-3-4-11/h5-9,11,23H,3-4H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287717
PNG
(US10085984, Example 95 | US11040034, Ex. No. 95)
Show SMILES FC(F)(F)c1cc(cnn1)-c1nc2ccc(Cl)nc2n1C1CC1
Show InChI InChI=1S/C14H9ClF3N5/c15-11-4-3-9-13(21-11)23(8-1-2-8)12(20-9)7-5-10(14(16,17)18)22-19-6-7/h3-6,8H,1-2H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B1


(Homo sapiens (Human))
BDBM287719
PNG
(US10085984, Example 97 | US11040034, Ex. No. 97)
Show SMILES CCCCc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C18H18F2N4/c1-2-3-4-12-7-11(10-21-23-12)18-22-16-8-14(19)15(20)9-17(16)24(18)13-5-6-13/h7-10,13H,2-6H2,1H3
PDB

Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287728
PNG
(US10085984, Example 106 | US11040034, Ex. No. 106)
Show SMILES Fc1cc2nc(-c3cnnc4CCCCc34)n(C3CC3)c2cc1F
Show InChI InChI=1S/C18H16F2N4/c19-13-7-16-17(8-14(13)20)24(10-5-6-10)18(22-16)12-9-21-23-15-4-2-1-3-11(12)15/h7-10H,1-6H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287746
PNG
(US10085984, Example 124 | US11040034, Ex. No. 124)
Show SMILES CC(C)Sc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C17H16F2N4S/c1-9(2)24-16-5-10(8-20-22-16)17-21-14-6-12(18)13(19)7-15(14)23(17)11-3-4-11/h5-9,11H,3-4H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287634
PNG
(US10085984, Example 12 | US11040034, Ex. No. 12)
Show SMILES CC(C)(O)c1cc(cnn1)-c1nc2ccc(F)cc2n1C1CC1
Show InChI InChI=1S/C17H17FN4O/c1-17(2,23)15-7-10(9-19-21-15)16-20-13-6-3-11(18)8-14(13)22(16)12-4-5-12/h3,6-9,12,23H,4-5H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287643
PNG
(US10085984, Example 21 | US11040034, Ex. No. 21)
Show SMILES CNc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C15H13F2N5/c1-18-14-4-8(7-19-21-14)15-20-12-5-10(16)11(17)6-13(12)22(15)9-2-3-9/h4-7,9H,2-3H2,1H3,(H,18,21)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287657
PNG
(US10085984, Example 35 | US11040034, Ex. No. 35)
Show SMILES Cc1cc(cnn1)-c1nc2ccc(cc2n1C1CC1)C#N
Show InChI InChI=1S/C16H13N5/c1-10-6-12(9-18-20-10)16-19-14-5-2-11(8-17)7-15(14)21(16)13-3-4-13/h2,5-7,9,13H,3-4H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287658
PNG
(US10085984, Example 36 | US11040034, Ex. No. 36)
Show SMILES CN1CCN(CC1)c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C19H20F2N6/c1-25-4-6-26(7-5-25)18-8-12(11-22-24-18)19-23-16-9-14(20)15(21)10-17(16)27(19)13-2-3-13/h8-11,13H,2-7H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287662
PNG
(US10085984, Example 40 | US11040034, Ex. No. 40)
Show SMILES CCn1c(nc2ccc(cc12)C#N)-c1cnnc(OC)c1
Show InChI InChI=1S/C15H13N5O/c1-3-20-13-6-10(8-16)4-5-12(13)18-15(20)11-7-14(21-2)19-17-9-11/h4-7,9H,3H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287693
PNG
(US10085984, Example 71 | US11040034, Ex. No. 71)
Show SMILES Fc1cc2nc(-c3cnnc(CC(F)(F)F)c3)n(C3CC3)c2cc1F
Show InChI InChI=1S/C16H11F5N4/c17-11-4-13-14(5-12(11)18)25(10-1-2-10)15(23-13)8-3-9(24-22-7-8)6-16(19,20)21/h3-5,7,10H,1-2,6H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287694
PNG
(US10085984, Example 72 | US11040034, Ex. No. 72)
Show SMILES CCn1c(nc2cc(F)c(F)cc12)-c1cnnc(c1)C1CC1
Show InChI InChI=1S/C16H14F2N4/c1-2-22-15-7-12(18)11(17)6-14(15)20-16(22)10-5-13(9-3-4-9)21-19-8-10/h5-9H,2-4H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287707
PNG
(US10085984, Example 85 | US11040034, Ex. No. 85)
Show SMILES Fc1cc2nc(-c3cnnc(c3)C(F)(F)F)n(C3CC3)c2cc1F
Show InChI InChI=1S/C15H9F5N4/c16-9-4-11-12(5-10(9)17)24(8-1-2-8)14(22-11)7-3-13(15(18,19)20)23-21-6-7/h3-6,8H,1-2H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287714
PNG
(US10085984, Example 92 | US11040034, Ex. No. 92)
Show SMILES FCc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C15H11F3N4/c16-6-9-3-8(7-19-21-9)15-20-13-4-11(17)12(18)5-14(13)22(15)10-1-2-10/h3-5,7,10H,1-2,6H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287741
PNG
(US10085984, Example 119 | US11040034, Ex. No. 119)
Show SMILES FC(F)c1cc(cnn1)-c1nc2cc(F)c(Cl)cc2n1C1CC1
Show InChI InChI=1S/C15H10ClF3N4/c16-9-4-13-11(5-10(9)17)21-15(23(13)8-1-2-8)7-3-12(14(18)19)22-20-6-7/h3-6,8,14H,1-2H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287641
PNG
(US10085984, Example 19 | US11040034, Ex. No. 19)
Show SMILES Cc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C15H12F2N4/c1-8-4-9(7-18-20-8)15-19-13-5-11(16)12(17)6-14(13)21(15)10-2-3-10/h4-7,10H,2-3H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM504360
PNG
(US11040034, Ex. No. 39)
Show SMILES CB(O)N1CCN(CC1)c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C19H21BF2N6O/c1-20(29)27-6-4-26(5-7-27)18-8-12(11-23-25-18)19-24-16-9-14(21)15(22)10-17(16)28(19)13-2-3-13/h8-11,13,29H,2-7H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287666
PNG
(US10085984, Example 44 | US11040034, Ex. No. 44)
Show SMILES Fc1cc2nc(-c3cnnc(c3)N3CCC(F)(F)CC3)n(C3CC3)c2cc1F
Show InChI InChI=1S/C19H17F4N5/c20-13-8-15-16(9-14(13)21)28(12-1-2-12)18(25-15)11-7-17(26-24-10-11)27-5-3-19(22,23)4-6-27/h7-10,12H,1-6H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287667
PNG
(US10085984, Example 45 | US11040034, Ex. No. 45)
Show SMILES Cc1cc(cnn1)-c1nc2ccc(Cl)nc2n1C1CC1
Show InChI InChI=1S/C14H12ClN5/c1-8-6-9(7-16-19-8)13-17-11-4-5-12(15)18-14(11)20(13)10-2-3-10/h4-7,10H,2-3H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287671
PNG
(US10085984, Example 49 | US11040034, Ex. No. 49)
Show SMILES Fc1ccc(cc1)-c1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C20H13F3N4/c21-13-3-1-11(2-4-13)17-7-12(10-24-26-17)20-25-18-8-15(22)16(23)9-19(18)27(20)14-5-6-14/h1-4,7-10,14H,5-6H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287679
PNG
(US10085984, Example 57 | US11040034, Ex. No. 57)
Show SMILES CC(F)(F)COc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C17H14F4N4O/c1-17(20,21)8-26-15-4-9(7-22-24-15)16-23-13-5-11(18)12(19)6-14(13)25(16)10-2-3-10/h4-7,10H,2-3,8H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287697
PNG
(US10085984, Example 75 | US11040034, Ex. No. 75)
Show SMILES N#Cc1ccc2nc(-c3cnnc(c3)C3CC3)n(C3CC3)c2c1
Show InChI InChI=1S/C18H15N5/c19-9-11-1-6-15-17(7-11)23(14-4-5-14)18(21-15)13-8-16(12-2-3-12)22-20-10-13/h1,6-8,10,12,14H,2-5H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287698
PNG
(US10085984, Example 76 | US11040034, Ex. No. 76)
Show SMILES FC(F)c1cc(cnn1)-c1nc2ccc(nc2n1C1CC1)C#N
Show InChI InChI=1S/C15H10F2N6/c16-13(17)12-5-8(7-19-22-12)14-21-11-4-1-9(6-18)20-15(11)23(14)10-2-3-10/h1,4-5,7,10,13H,2-3H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287708
PNG
(US10085984, Example 86 | US11040034, Ex. No. 86)
Show SMILES FC(F)(F)c1cc(cnn1)-c1nc2ccc(cc2n1C1CC1)C#N
Show InChI InChI=1S/C16H10F3N5/c17-16(18,19)14-6-10(8-21-23-14)15-22-12-4-1-9(7-20)5-13(12)24(15)11-2-3-11/h1,4-6,8,11H,2-3H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287715
PNG
(US10085984, Example 93 | US11040034, Ex. No. 93)
Show SMILES Cc1nncc(-c2nc3cc(F)c(F)cc3n2C2CC2)c1C
Show InChI InChI=1S/C16H14F2N4/c1-8-9(2)21-19-7-11(8)16-20-14-5-12(17)13(18)6-15(14)22(16)10-3-4-10/h5-7,10H,3-4H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287726
PNG
(US10085984, Example 104 | US11040034, Ex. No. 104)
Show SMILES Cn1c(nc2cc(F)c(F)cc12)-c1cnnc(c1)C(F)F
Show InChI InChI=1S/C13H8F4N4/c1-21-11-4-8(15)7(14)3-9(11)19-13(21)6-2-10(12(16)17)20-18-5-6/h2-5,12H,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287739
PNG
(US10085984, Example 117 | US11040034, Ex. No. 117)
Show SMILES Fc1cc2nc(-c3cnnc(OCC4CC4)c3)n(C3CC3)c2cc1F
Show InChI InChI=1S/C18H16F2N4O/c19-13-6-15-16(7-14(13)20)24(12-3-4-12)18(22-15)11-5-17(23-21-8-11)25-9-10-1-2-10/h5-8,10,12H,1-4,9H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287742
PNG
(US10085984, Example 120 | US11040034, Ex. No. 120)
Show SMILES FC(F)c1cc(cnn1)-c1nc2cc(F)c(cc2n1C1CC1)C#N
Show InChI InChI=1S/C16H10F3N5/c17-11-5-12-14(4-8(11)6-20)24(10-1-2-10)16(22-12)9-3-13(15(18)19)23-21-7-9/h3-5,7,10,15H,1-2H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287747
PNG
(US10085984, Example 125 | US11040034, Ex. No. 125)
Show SMILES FC(F)Sc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C15H10F4N4S/c16-9-4-11-12(5-10(9)17)23(8-1-2-8)14(21-11)7-3-13(22-20-6-7)24-15(18)19/h3-6,8,15H,1-2H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287632
PNG
(US10085984, Example 10 | US11040034, Ex. No. 10)
Show SMILES Fc1ccc2nc(-c3cnnc(c3)N3CCOCC3)n(C3CC3)c2c1
Show InChI InChI=1S/C18H18FN5O/c19-13-1-4-15-16(10-13)24(14-2-3-14)18(21-15)12-9-17(22-20-11-12)23-5-7-25-8-6-23/h1,4,9-11,14H,2-3,5-8H2
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287646
PNG
(US10085984, Example 24 | US11040034, Ex. No. 24)
Show SMILES CC(C)Oc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C17H16F2N4O/c1-9(2)24-16-5-10(8-20-22-16)17-21-14-6-12(18)13(19)7-15(14)23(17)11-3-4-11/h5-9,11H,3-4H2,1-2H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287650
PNG
(US10085984, Example 28 | US11040034, Ex. No. 28)
Show SMILES COCCNc1cc(cnn1)-c1nc2cc(F)c(F)cc2n1C1CC1
Show InChI InChI=1S/C17H17F2N5O/c1-25-5-4-20-16-6-10(9-21-23-16)17-22-14-7-12(18)13(19)8-15(14)24(17)11-2-3-11/h6-9,11H,2-5H2,1H3,(H,20,23)
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Cytochrome P450 11B2


(Homo sapiens (Human))
BDBM287653
PNG
(US10085984, Example 31 | US11040034, Ex. No. 31)
Show SMILES CCS(=O)(=O)NCc1cc(cnn1)-c1nc2ccc(F)cc2n1C1CC1
Show InChI InChI=1S/C17H18FN5O2S/c1-2-26(24,25)20-10-13-7-11(9-19-22-13)17-21-15-6-3-12(18)8-16(15)23(17)14-4-5-14/h3,6-9,14,20H,2,4-5,10H2,1H3
PDB

Reactome pathway

UniProtKB/SwissProt

antibodypedia
GoogleScholar
PC cid
PC sid
UniChem
US Patent
n/an/a 50n/an/an/an/an/an/a



PHASEBIO PHARMACEUTICALS, INC.

US Patent


Assay Description
Enzyme assays for inhibitor screening employed CYP11B2 and CYP11B1 enzyme enriched microsomes and were run at the Km of the respective substrates. Pr...


US Patent US11040034 (2021)

More data for this
Ligand-Target Pair
Displayed 1 to 50 (of 272 total )  |  Next  |  Last  >>
* indicates data uncertainty>20%