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Patent code US11046658

Compile Data Set for Download or QSAR

Found 260 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506852
PNG
(US11046658, Example 7)
Show SMILES CCNC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C17H18F3N5O3/c1-3-23-14(26)12-13(21)24-7-11(25-12)10-6-9(5-4-8(10)2)16(28,15(22)27)17(18,19)20/h4-7,28H,3H2,1-2H3,(H2,21,24)(H2,22,27)(H,23,26)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506863
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@H]1CC[C@](O)(CC1)C(F)(F)F)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C22H23F6N5O4/c1-10-2-3-11(20(37,18(30)35)22(26,27)28)8-13(10)14-9-31-16(29)15(33-14)17(34)32-12-4-6-19(36,7-5-12)21(23,24)25/h2-3,8-9,12,36-37H,4-7H2,1H3,(H2,29,31)(H2,30,35)(H,32,34)/t12-,19-,20?
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506870
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@]12CCC(CC1)(CC2)C#C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C25H26F3N5O3/c1-3-22-6-9-23(10-7-22,11-8-22)33-20(34)18-19(29)31-13-17(32-18)16-12-15(5-4-14(16)2)24(36,21(30)35)25(26,27)28/h1,4-5,12-13,36H,6-11H2,2H3,(H2,29,31)(H2,30,35)(H,33,34)/t22?,23-,24?
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506888
PNG
(3-amino-6-(5-(3-amino-1,1,1-trifluoro-2-hydroxy-3-...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCC(O)C(F)(F)F)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C18H17F6N5O4/c1-7-2-3-8(16(33,15(26)32)18(22,23)24)4-9(7)10-5-27-13(25)12(29-10)14(31)28-6-11(30)17(19,20)21/h2-5,11,30,33H,6H2,1H3,(H2,25,27)(H2,26,32)(H,28,31)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506893
PNG
(US11046658, Example 47)
Show SMILES COCC#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C18H17F3N4O3/c1-10-5-6-11(17(27,16(23)26)18(19,20)21)8-12(10)14-9-24-15(22)13(25-14)4-3-7-28-2/h5-6,8-9,27H,7H2,1-2H3,(H2,22,24)(H2,23,26)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506896
PNG
(2-(3-(5-amino-6-(3-hydroxy-3- methylbut-1-ynyl)pyr...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C#CC(C)(C)O)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C19H19F3N4O3/c1-10-4-5-11(18(29,16(24)27)19(20,21)22)8-12(10)14-9-25-15(23)13(26-14)6-7-17(2,3)28/h4-5,8-9,28-29H,1-3H3,(H2,23,25)(H2,24,27)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506900
PNG
(2-(3-(5-amino-6-((1-methyl- 1H-pyrazol-4- yl)ethyn...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cnn(C)c1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C20H17F3N6O2/c1-11-3-5-13(19(31,18(25)30)20(21,22)23)7-14(11)16-9-26-17(24)15(28-16)6-4-12-8-27-29(2)10-12/h3,5,7-10,31H,1-2H3,(H2,24,26)(H2,25,30)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506900
PNG
(2-(3-(5-amino-6-((1-methyl- 1H-pyrazol-4- yl)ethyn...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cnn(C)c1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C20H17F3N6O2/c1-11-3-5-13(19(31,18(25)30)20(21,22)23)7-14(11)16-9-26-17(24)15(28-16)6-4-12-8-27-29(2)10-12/h3,5,7-10,31H,1-2H3,(H2,24,26)(H2,25,30)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506907
PNG
(2-(3-(5-amino-6-((3- fluorophenyl)ethynyl)pyrazin-...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cccc(F)c1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C22H16F4N4O2/c1-12-5-7-14(21(32,20(28)31)22(24,25)26)10-16(12)18-11-29-19(27)17(30-18)8-6-13-3-2-4-15(23)9-13/h2-5,7,9-11,32H,1H3,(H2,27,29)(H2,28,31)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506914
PNG
(US11046658, Example 68++)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1cn2ccnc2cn1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C22H16F3N7O2/c1-12-2-3-13(21(34,20(27)33)22(23,24)25)8-15(12)17-9-30-19(26)16(31-17)5-4-14-11-32-7-6-28-18(32)10-29-14/h2-3,6-11,34H,1H3,(H2,26,30)(H2,27,33)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506916
PNG
(2-(3-(5-amino-6-(2- methyloxazol-5- yl)pyrazin-2-y...)
Show SMILES Cc1ncc(o1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C18H16F3N5O3/c1-8-3-4-10(17(28,16(23)27)18(19,20)21)5-11(8)12-6-25-15(22)14(26-12)13-7-24-9(2)29-13/h3-7,28H,1-2H3,(H2,22,25)(H2,23,27)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506922
PNG
(2-(3-(5-amino-6-(1-(2- cyanopropan-2-yl)-1H- pyraz...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(c1)C(C)(C)C#N)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C21H20F3N7O2/c1-11-4-5-13(20(33,18(27)32)21(22,23)24)6-14(11)15-8-28-17(26)16(30-15)12-7-29-31(9-12)19(2,3)10-25/h4-9,33H,1-3H3,(H2,26,28)(H2,27,32)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506930
PNG
(2-(3-(5-amino-6-(2- cyclopropylthiazol-5- yl)pyraz...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnc(s1)C1CC1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C20H18F3N5O2S/c1-9-2-5-11(19(30,18(25)29)20(21,22)23)6-12(9)13-7-26-16(24)15(28-13)14-8-27-17(31-14)10-3-4-10/h2,5-8,10,30H,3-4H2,1H3,(H2,24,26)(H2,25,29)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506937
PNG
(2-(3-(5-amino-6-(4-(2- hydroxypropan-2- yl)phenyl)...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(cc1)C(C)(C)O)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C23H23F3N4O3/c1-12-4-7-15(22(33,20(28)31)23(24,25)26)10-16(12)17-11-29-19(27)18(30-17)13-5-8-14(9-6-13)21(2,3)32/h4-11,32-33H,1-3H3,(H2,27,29)(H2,28,31)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506940
PNG
(US11046658, Example 94)
Show SMILES CNC(=O)C(O)(c1ccc(C)c(c1)-c1cnc(N)c(n1)-n1cncn1)C(F)(F)F
Show InChI InChI=1S/C17H16F3N7O2/c1-9-3-4-10(16(29,15(28)22-2)17(18,19)20)5-11(9)12-6-24-13(21)14(26-12)27-8-23-7-25-27/h3-8,29H,1-2H3,(H2,21,24)(H,22,28)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506960
PNG
(2-(3-(6-(4-acetylpiperazin-1-yl)-5- aminopyrazin-2...)
Show SMILES CC(=O)N1CCN(CC1)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C20H23F3N6O3/c1-11-3-4-13(19(32,18(25)31)20(21,22)23)9-14(11)15-10-26-16(24)17(27-15)29-7-5-28(6-8-29)12(2)30/h3-4,9-10,32H,5-8H2,1-2H3,(H2,24,26)(H2,25,31)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506968
PNG
(2-(3-(5-amino-6-(4-(2- cyanophenyl)piperazin-1- yl...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1ccccc1C#C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C26H25F3N6O2/c1-3-17-6-4-5-7-21(17)34-10-12-35(13-11-34)23-22(30)32-15-20(33-23)19-14-18(9-8-16(19)2)25(37,24(31)36)26(27,28)29/h1,4-9,14-15,37H,10-13H2,2H3,(H2,30,32)(H2,31,36)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506974
PNG
(2-(3-(5-amino-6-(4-(3- cyanopyrazin-2-yl)piperazin...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)N1CCN(CC1)c1nccnc1C#N)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C23H22F3N9O2/c1-13-2-3-14(22(37,21(29)36)23(24,25)26)10-15(13)17-12-32-18(28)20(33-17)35-8-6-34(7-9-35)19-16(11-27)30-4-5-31-19/h2-5,10,12,37H,6-9H2,1H3,(H2,28,32)(H2,29,36)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506849
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NCC1(CC1)C#N)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C20H19F3N6O3/c1-10-2-3-11(19(32,17(26)31)20(21,22)23)6-12(10)13-7-27-15(25)14(29-13)16(30)28-9-18(8-24)4-5-18/h2-3,6-7,32H,4-5,9H2,1H3,(H2,25,27)(H2,26,31)(H,28,30)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506853
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES C[C@@H](CC#N)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C19H19F3N6O3/c1-9-3-4-11(18(31,17(25)30)19(20,21)22)7-12(9)13-8-26-15(24)14(28-13)16(29)27-10(2)5-6-23/h3-4,7-8,10,31H,5H2,1-2H3,(H2,24,26)(H2,25,30)(H,27,29)/t10-,18?/m0/s1
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506858
PNG
(US11046658, Example 13)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC(C)(C)CO)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C19H22F3N5O4/c1-9-4-5-10(18(31,16(24)30)19(20,21)22)6-11(9)12-7-25-14(23)13(26-12)15(29)27-17(2,3)8-28/h4-7,28,31H,8H2,1-3H3,(H2,23,25)(H2,24,30)(H,27,29)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506858
PNG
(US11046658, Example 13)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC(C)(C)CO)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C19H22F3N5O4/c1-9-4-5-10(18(31,16(24)30)19(20,21)22)6-11(9)12-7-25-14(23)13(26-12)15(29)27-17(2,3)8-28/h4-7,28,31H,8H2,1-3H3,(H2,23,25)(H2,24,30)(H,27,29)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506864
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@H]1CC[C@@H](CC1)C(C)(C)C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C25H32F3N5O3/c1-13-5-6-15(24(36,22(30)35)25(26,27)28)11-17(13)18-12-31-20(29)19(33-18)21(34)32-16-9-7-14(8-10-16)23(2,3)4/h5-6,11-12,14,16,36H,7-10H2,1-4H3,(H2,29,31)(H2,30,35)(H,32,34)/t14-,16-,24?
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506865
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES CC[C@@H](CC#N)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C20H21F3N6O3/c1-3-12(6-7-24)28-17(30)15-16(25)27-9-14(29-15)13-8-11(5-4-10(13)2)19(32,18(26)31)20(21,22)23/h4-5,8-9,12,32H,3,6H2,1-2H3,(H2,25,27)(H2,26,31)(H,28,30)/t12-,19?/m0/s1
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506868
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@]12CC(C1)(C2)C#N)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C21H19F3N6O3/c1-10-2-3-11(20(33,17(27)32)21(22,23)24)4-12(10)13-5-28-15(26)14(29-13)16(31)30-19-6-18(7-19,8-19)9-25/h2-5,33H,6-8H2,1H3,(H2,26,28)(H2,27,32)(H,30,31)/t18?,19-,20?
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506868
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@]12CC(C1)(C2)C#N)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C21H19F3N6O3/c1-10-2-3-11(20(33,17(27)32)21(22,23)24)4-12(10)13-5-28-15(26)14(29-13)16(31)30-19-6-18(7-19,8-19)9-25/h2-5,33H,6-8H2,1H3,(H2,26,28)(H2,27,32)(H,30,31)/t18?,19-,20?
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506869
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@]12CC(C1)(CC2)C#N)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C22H21F3N6O3/c1-11-2-3-12(21(34,18(28)33)22(23,24)25)6-13(11)14-7-29-16(27)15(30-14)17(32)31-20-5-4-19(8-20,9-20)10-26/h2-3,6-7,34H,4-5,8-9H2,1H3,(H2,27,29)(H2,28,33)(H,31,32)/t19?,20-,21?
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506869
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)N[C@]12CC(C1)(CC2)C#N)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C22H21F3N6O3/c1-11-2-3-12(21(34,18(28)33)22(23,24)25)6-13(11)14-7-29-16(27)15(30-14)17(32)31-20-5-4-19(8-20,9-20)10-26/h2-3,6-7,34H,4-5,8-9H2,1H3,(H2,27,29)(H2,28,33)(H,31,32)/t19?,20-,21?
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506871
PNG
(2-(3-(5-amino-6-((R)-2- (methoxymethyl)azetidine- ...)
Show SMILES COC[C@H]1CCN1C(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C20H22F3N5O4/c1-10-3-4-11(19(31,18(25)30)20(21,22)23)7-13(10)14-8-26-16(24)15(27-14)17(29)28-6-5-12(28)9-32-2/h3-4,7-8,12,31H,5-6,9H2,1-2H3,(H2,24,26)(H2,25,30)/t12-,19?/m1/s1
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506867
PNG
(3-amino-6-(5-(3-amino- 1,1,1-trifluoro-2-hydroxy- ...)
Show SMILES CO[C@H]1CC[C@@H](CC1)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C22H26F3N5O4/c1-11-3-4-12(21(33,20(27)32)22(23,24)25)9-15(11)16-10-28-18(26)17(30-16)19(31)29-13-5-7-14(34-2)8-6-13/h3-4,9-10,13-14,33H,5-8H2,1-2H3,(H2,26,28)(H2,27,32)(H,29,31)/t13-,14-,21?
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506880
PNG
(3-amino-6-(5-(1- amino-3,3-difluoro- 2-hydroxy-1- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(=O)NC(C)(C)CO)C(O)(C(F)F)C(N)=O
Show InChI InChI=1S/C19H23F2N5O4/c1-9-4-5-10(19(30,16(20)21)17(23)29)6-11(9)12-7-24-14(22)13(25-12)15(28)26-18(2,3)8-27/h4-7,16,27,30H,8H2,1-3H3,(H2,22,24)(H2,23,29)(H,26,28)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506886
PNG
(US11046658, Example 41)
Show SMILES CC(C)NC(=O)c1nc(cnc1N)-c1cc(ccc1C)C(O)(CNC(=O)C(C)(C)O)C(F)(F)F
Show InChI InChI=1S/C22H28F3N5O4/c1-11(2)29-18(31)16-17(26)27-9-15(30-16)14-8-13(7-6-12(14)3)21(34,22(23,24)25)10-28-19(32)20(4,5)33/h6-9,11,33-34H,10H2,1-5H3,(H2,26,27)(H,28,32)(H,29,31)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506892
PNG
(US11046658, Example 46)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C(F)(F)F)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C15H12F6N4O2/c1-6-2-3-7(13(27,12(23)26)15(19,20)21)4-8(6)9-5-24-11(22)10(25-9)14(16,17)18/h2-5,27H,1H3,(H2,22,24)(H2,23,26)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506897
PNG
(2-(3-(5-amino-6-(4- hydroxypent-1-ynyl)pyrazin-2- ...)
Show SMILES CC(O)CC#Cc1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C19H19F3N4O3/c1-10-6-7-12(18(29,17(24)28)19(20,21)22)8-13(10)15-9-25-16(23)14(26-15)5-3-4-11(2)27/h6-9,11,27,29H,4H2,1-2H3,(H2,23,25)(H2,24,28)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506898
PNG
(2-(3-(6-((1H-pyrazol-5- yl)ethynyl)-5-aminopyrazin...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1ccn[nH]1)C(O)(C(N)=O)C(F)(F)F
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506901
PNG
(2-(3-(5-amino-6-(pyridin-2- ylethynyl)pyrazin-2-yl...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C#Cc1ccccn1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C21H16F3N5O2/c1-12-5-6-13(20(31,19(26)30)21(22,23)24)10-15(12)17-11-28-18(25)16(29-17)8-7-14-4-2-3-9-27-14/h2-6,9-11,31H,1H3,(H2,25,28)(H2,26,30)
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n/an/a<100n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506910
PNG
(2-(3-(5-amino-6-((4- methyltetrahydro-2H-pyran-4- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C#CC1(C)CCOCC1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O3/c1-13-3-4-14(21(31,19(27)30)22(23,24)25)11-15(13)17-12-28-18(26)16(29-17)5-6-20(2)7-9-32-10-8-20/h3-4,11-12,31H,7-10H2,1-2H3,(H2,26,28)(H2,27,30)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506910
PNG
(2-(3-(5-amino-6-((4- methyltetrahydro-2H-pyran-4- ...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)C#CC1(C)CCOCC1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C22H23F3N4O3/c1-13-3-4-14(21(31,19(27)30)22(23,24)25)11-15(13)17-12-28-18(26)16(29-17)5-6-20(2)7-9-32-10-8-20/h3-4,11-12,31H,7-10H2,1-2H3,(H2,26,28)(H2,27,30)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506917
PNG
(2-(3-(5-amino-6-(1- methyl-1H-pyrazol-4- yl)pyrazi...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(C)c1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C18H17F3N6O2/c1-9-3-4-11(17(29,16(23)28)18(19,20)21)5-12(9)13-7-24-15(22)14(26-13)10-6-25-27(2)8-10/h3-8,29H,1-2H3,(H2,22,24)(H2,23,28)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506917
PNG
(2-(3-(5-amino-6-(1- methyl-1H-pyrazol-4- yl)pyrazi...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(C)c1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C18H17F3N6O2/c1-9-3-4-11(17(29,16(23)28)18(19,20)21)5-12(9)13-7-24-15(22)14(26-13)10-6-25-27(2)8-10/h3-8,29H,1-2H3,(H2,22,24)(H2,23,28)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506920
PNG
(2-(3-(5-amino-6-(1- methyl-1H-1,2,3-triazol-5- yl)...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnnn1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C17H16F3N7O2/c1-8-3-4-9(16(29,15(22)28)17(18,19)20)5-10(8)11-6-23-14(21)13(25-11)12-7-24-26-27(12)2/h3-7,29H,1-2H3,(H2,21,23)(H2,22,28)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506927
PNG
(2-(3-(5-amino-6- (pyrimidin-5-yl)pyrazin-2- yl)-4-...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1cncnc1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C18H15F3N6O2/c1-9-2-3-11(17(29,16(23)28)18(19,20)21)4-12(9)13-7-26-15(22)14(27-13)10-5-24-8-25-6-10/h2-8,29H,1H3,(H2,22,26)(H2,23,28)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506928
PNG
(2-(3-(5-amino-6-(6- methylpyridin-3- yl)pyrazin-2-...)
Show SMILES Cc1ccc(cn1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C20H18F3N5O2/c1-10-3-6-13(19(30,18(25)29)20(21,22)23)7-14(10)15-9-27-17(24)16(28-15)12-5-4-11(2)26-8-12/h3-9,30H,1-2H3,(H2,24,27)(H2,25,29)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506934
PNG
(2-(3-(5-amino-6-(4- (hydroxymethyl)phenyl) pyrazin...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(CO)cc1)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C21H19F3N4O3/c1-11-2-7-14(20(31,19(26)30)21(22,23)24)8-15(11)16-9-27-18(25)17(28-16)13-5-3-12(10-29)4-6-13/h2-9,29,31H,10H2,1H3,(H2,25,27)(H2,26,30)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506943
PNG
(US11046658, Example 97)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1ccc(cc1)B(O)O)C(O)(C(N)=O)C(F)(F)F
Show InChI InChI=1S/C20H18BF3N4O4/c1-10-2-5-12(19(30,18(26)29)20(22,23)24)8-14(10)15-9-27-17(25)16(28-15)11-3-6-13(7-4-11)21(31)32/h2-9,30-32H,1H3,(H2,25,27)(H2,26,29)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506946
PNG
(2-(3-(5-amino-6-(2- methyloxazol-5- yl)pyrazin-2-y...)
Show SMILES Cc1ncc(o1)-c1nc(cnc1N)-c1cc(ccc1C)C(O)(C(F)F)C(N)=O
Show InChI InChI=1S/C18H17F2N5O3/c1-8-3-4-10(18(27,16(19)20)17(22)26)5-11(8)12-6-24-15(21)14(25-12)13-7-23-9(2)28-13/h3-7,16,27H,1-2H3,(H2,21,24)(H2,22,26)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506947
PNG
(2-(3-(5-amino-6-(2- methyl-2H-1,2,3- triazol-4-yl)...)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnn(C)n1)C(O)(C(F)F)C(N)=O
Show InChI InChI=1S/C17H17F2N7O2/c1-8-3-4-9(17(28,15(18)19)16(21)27)5-10(8)11-6-22-14(20)13(24-11)12-7-23-26(2)25-12/h3-7,15,28H,1-2H3,(H2,20,22)(H2,21,27)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform


(Homo sapiens (Human))
BDBM506948
PNG
(US11046658, Example 102)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnc(s1)C1CC1)C(O)(CNC=O)C(F)(F)F
Show InChI InChI=1S/C21H20F3N5O2S/c1-11-2-5-13(20(31,9-26-10-30)21(22,23)24)6-14(11)15-7-27-18(25)17(29-15)16-8-28-19(32-16)12-3-4-12/h2,5-8,10,12,31H,3-4,9H2,1H3,(H2,25,27)(H,26,30)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506948
PNG
(US11046658, Example 102)
Show SMILES Cc1ccc(cc1-c1cnc(N)c(n1)-c1cnc(s1)C1CC1)C(O)(CNC=O)C(F)(F)F
Show InChI InChI=1S/C21H20F3N5O2S/c1-11-2-5-13(20(31,9-26-10-30)21(22,23)24)6-14(11)15-7-27-18(25)17(29-15)16-8-28-19(32-16)12-3-4-12/h2,5-8,10,12,31H,3-4,9H2,1H3,(H2,25,27)(H,26,30)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform


(Homo sapiens (Human))
BDBM506950
PNG
(US11046658, Example 104)
Show SMILES CC(=O)NCC(O)(c1ccc(C)c(c1)-c1cnc(N)c(n1)-c1cnn(CC(F)(F)F)c1)C(F)(F)F
Show InChI InChI=1S/C21H20F6N6O2/c1-11-3-4-14(19(35,21(25,26)27)9-30-12(2)34)5-15(11)16-7-29-18(28)17(32-16)13-6-31-33(8-13)10-20(22,23)24/h3-8,35H,9-10H2,1-2H3,(H2,28,29)(H,30,34)
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Incyte Corporation

US Patent


Assay Description
Materials: [γ-33P]ATP (10 mCi/mL) and Wheat Germ Agglutinin (WGA) YSi SPA Scintillation Beads was purchased from Perkin Elmer (Waltham, Mass.). ...


US Patent US11046658 (2021)

More data for this
Ligand-Target Pair
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* indicates data uncertainty>20%