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Found 46 Enz. Inhib. hit(s) with all data for entry = 6429
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM50397656(CHEMBL2181745 | US8796280, 17)
Affinity DataKi:  380nM ΔG°:  -36.6kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128328(US8796280, 18)
Affinity DataKi:  400nM ΔG°:  -36.5kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128314(US8796280, 3)
Affinity DataKi:  450nM ΔG°:  -36.2kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128329(US8796280, 19)
Affinity DataKi:  470nM ΔG°:  -36.1kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128330(US8796280, 20)
Affinity DataKi:  480nM ΔG°:  -36.1kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128331(US8796280, 21)
Affinity DataKi:  590nM ΔG°:  -35.6kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128332(US8796280, 22)
Affinity DataKi:  620nM ΔG°:  -35.4kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128333(US8796280, 23)
Affinity DataKi:  700nM ΔG°:  -35.1kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128334(US8796280, 24)
Affinity DataKi:  720nM ΔG°:  -35.1kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128335(US8796280, 25)
Affinity DataKi:  850nM ΔG°:  -34.6kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128336(US8796280, 26)
Affinity DataKi:  950nM ΔG°:  -34.4kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128312(US8796280, 1)
Affinity DataKi:  1.01E+3nM ΔG°:  -34.2kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128313(US8796280, 2)
Affinity DataKi:  1.26E+3nM ΔG°:  -33.7kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128337(US8796280, 27)
Affinity DataKi:  1.32E+3nM ΔG°:  -33.6kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128321(US8796280, 10)
Affinity DataKi:  1.40E+3nM ΔG°:  -33.4kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128319(US8796280, 8)
Affinity DataKi:  1.42E+3nM ΔG°:  -33.4kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128338(US8796280, 28)
Affinity DataKi:  1.47E+3nM ΔG°:  -33.3kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128339(US8796280, 29)
Affinity DataKi:  1.49E+3nM ΔG°:  -33.3kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128315(US8796280, 4)
Affinity DataKi:  1.57E+3nM ΔG°:  -33.1kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128340(US8796280, 30)
Affinity DataKi:  1.58E+3nM ΔG°:  -33.1kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128341(US8796280, 31)
Affinity DataKi:  1.59E+3nM ΔG°:  -33.1kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128342(US8796280, 32)
Affinity DataKi:  1.93E+3nM ΔG°:  -32.6kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128317(US8796280, 6)
Affinity DataKi:  2.12E+3nM ΔG°:  -32.4kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128343(US8796280, 33)
Affinity DataKi:  2.21E+3nM ΔG°:  -32.3kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128316(US8796280, 5)
Affinity DataKi:  2.32E+3nM ΔG°:  -32.2kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128318(US8796280, 7)
Affinity DataKi:  2.59E+3nM ΔG°:  -31.9kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128344(US8796280, 34)
Affinity DataKi:  2.60E+3nM ΔG°:  -31.9kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128345(US8796280, 35)
Affinity DataKi:  2.64E+3nM ΔG°:  -31.8kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128346(US8796280, 36)
Affinity DataKi:  2.69E+3nM ΔG°:  -31.8kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128347(US8796280, 37)
Affinity DataKi:  2.82E+3nM ΔG°:  -31.7kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128348(US8796280, 38)
Affinity DataKi:  2.90E+3nM ΔG°:  -31.6kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128349(US8796280, 39)
Affinity DataKi:  2.95E+3nM ΔG°:  -31.6kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128320(US8796280, 9)
Affinity DataKi:  2.98E+3nM ΔG°:  -31.5kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128350(US8796280, 40)
Affinity DataKi:  3.06E+3nM ΔG°:  -31.5kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128352(US8796280, 42)
Affinity DataKi:  3.90E+3nM ΔG°:  -30.9kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128351(US8796280, 41)
Affinity DataKi:  3.90E+3nM ΔG°:  -30.9kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128324(US8796280, 13)
Affinity DataKi:  4.03E+3nM ΔG°:  -30.8kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128353(US8796280, 43)
Affinity DataKi:  4.11E+3nM ΔG°:  -30.7kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128354(US8796280, 44)
Affinity DataKi:  4.44E+3nM ΔG°:  -30.6kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128355(US8796280, 45)
Affinity DataKi:  4.51E+3nM ΔG°:  -30.5kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128356(US8796280, 46)
Affinity DataKi:  4.65E+3nM ΔG°:  -30.4kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128322(US8796280, 11)
Affinity DataKi:  5.16E+3nM ΔG°:  -30.2kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128326(US8796280, 15)
Affinity DataKi:  5.38E+3nM ΔG°:  -30.1kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128327(US8796280, 16)
Affinity DataKi:  5.71E+3nM ΔG°:  -29.9kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128325(US8796280, 14)
Affinity DataKi:  5.85E+3nM ΔG°:  -29.9kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProstaglandin D2 receptor 2(Homo sapiens (Human))
Merck Serono

US Patent
LigandPNGBDBM128323(US8796280, 12)
Affinity DataKi:  8.43E+3nM ΔG°:  -29.0kJ/molepH: 7.4 T: 2°CAssay Description:The compounds of the present invention inhibit the binding of PGD2 to its receptor CRTH2. The inhibitory activity can be investigated by a radioligan...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent