Compile Data Set for Download or QSAR
maximum 50k data
Found 12 Enz. Inhib. hit(s) with all data for entry = 50000404
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  16nMAssay Description:Compound was tested in vitro for the contraction of guinea pig myenteric plexus preparation (mediated by Muscarinic M3 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005364((3S,4R)3-Methyl-3-(3-methyl-[1,2,4]oxadiazol-5-yl)...)
Affinity DataEC50:  110nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by muscarinic acetylcholine receptor M1)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005364((3S,4R)3-Methyl-3-(3-methyl-[1,2,4]oxadiazol-5-yl)...)
Affinity DataEC50:  13nMAssay Description:Compound was tested in vitro for the contraction of guinea pig myenteric plexus preparation (mediated by muscarinic acetylcholine receptor M3)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  19nMAssay Description:In vitro negative chronotropic effect of the compound on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  2.40nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  7nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  3.30nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  19nMAssay Description:In vitro negative chronotropic effect of the compound on electrically driven guinea pig atria(mediated by Muscarinic M2 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  16nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor(Cavia porcellus)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  2.40nMAssay Description:Compound was tested in vitro for the contraction of guinea pig myenteric plexus preparation (mediated by Muscarinic M3 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M1(RAT)
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005363((3R,4R)3-(3-Methyl-[1,2,4]oxadiazol-5-yl)-1-aza-bi...)
Affinity DataEC50:  7nMAssay Description:Compound was tested in vitro for depolarizing response on the rat superior cervical ganglion(mediated by Muscarinic M1 receptor)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
Merck Sharp And Dohme Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50005364((3S,4R)3-Methyl-3-(3-methyl-[1,2,4]oxadiazol-5-yl)...)
Affinity DataEC50:  14nMAssay Description:In vitro negative chronotropic effect of the compound on electrically driven guinea pig atria(mediated by muscarinic acetylcholine receptor M2)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed