Compile Data Set for Download or QSAR
maximum 50k data
Found 45 Enz. Inhib. hit(s) with all data for entry = 50017030
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176588(3-acetamido-N-(3-cyano-5-methyl-4-(4-phenoxyphenyl...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176580(1-(3-cyano-5-methyl-4-(4-phenoxyphenylamino)H-pyrr...)
Affinity DataIC50:  18nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176569(CHEMBL201389 | methyl 3-cyano-5-methyl-4-(4-phenox...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176595(CHEMBL377288 | ethyl 3-cyano-4-(4-(2-methoxyphenox...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176559(1-(3-cyano-4-(4-(2-methoxyphenoxy)phenylamino)-5-m...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176593(1-(3-cyano-4-(4-(3-methoxyphenoxy)phenylamino)-5-m...)
Affinity DataIC50:  29nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176592(1-(3-cyano-4-(4-(2-fluorophenoxy)phenylamino)-5-me...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176572(1-(3-cyano-5-methyl-4-(4-phenoxyphenylamino)H-pyrr...)
Affinity DataIC50:  36nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176586(CHEMBL202063 | N-(3-cyano-5-methyl-4-(4-phenoxyphe...)
Affinity DataIC50:  42nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176567(2-morpholinoethyl 3-cyano-4-(4-(2-methoxyphenoxy)p...)
Affinity DataIC50:  48nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176564(2-morpholinoethyl 3-cyano-5-methyl-4-(4-phenoxyphe...)
Affinity DataIC50:  58nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176565(CHEMBL202385 | ethyl 4-(4-benzylphenylamino)-3-cya...)
Affinity DataIC50:  68nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176576(2-morpholinoethyl 3-cyano-4-(4-(3-methoxyphenoxy)p...)
Affinity DataIC50:  76nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176571(CHEMBL201819 | N-(3-cyano-5-methyl-4-(4-phenoxyphe...)
Affinity DataIC50:  87nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176603(CHEMBL380765 | ethyl 3-cyano-5-methyl-4-(4-phenoxy...)
Affinity DataIC50:  94nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176575(3-cyano-5-methyl-4-(4-phenoxyphenylamino)H-pyrrolo...)
Affinity DataIC50:  147nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176584(6-(1H-benzo[d]imidazol-2-yl)-5-methyl-4-(4-phenoxy...)
Affinity DataIC50:  168nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176601(6-hydroxy-5-methyl-4-(4-phenoxyphenylamino)H-pyrro...)
Affinity DataIC50:  181nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176583(6-amino-5-methyl-4-(4-phenoxyphenylamino)H-pyrrolo...)
Affinity DataIC50:  190nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176591(CHEMBL382456 | ethyl 3-cyano-5-(methoxymethyl)-4-(...)
Affinity DataIC50:  191nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176560(CHEMBL201186 | ethyl 3-cyano-5-(hydroxymethyl)-4-(...)
Affinity DataIC50:  203nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176581(5-methyl-4-(4-phenoxyphenylamino)H-pyrrolo[1,2-b]p...)
Affinity DataIC50:  241nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176602(CHEMBL371969 | ethyl 3-cyano-5-(ethoxymethyl)-4-(4...)
Affinity DataIC50:  331nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176570(5-methyl-4-(4-phenoxyphenylamino)-6-(phenylamino)H...)
Affinity DataIC50:  361nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176573(3-cyano-5-methyl-N-(2-morpholinoethyl)-4-(4-phenox...)
Affinity DataIC50:  386nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176562(3-cyano-N,5-dimethyl-4-(4-phenoxyphenylamino)H-pyr...)
Affinity DataIC50:  397nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176566(5-methyl-6-(2-morpholinoethoxy)-4-(4-phenoxyphenyl...)
Affinity DataIC50:  521nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176599(CHEMBL201302 | ethyl 3-cyano-5-((2-methoxyethoxy)m...)
Affinity DataIC50:  566nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176578(CHEMBL203414 | ethyl 4-(4-(4-chlorophenoxy)phenyla...)
Affinity DataIC50:  642nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176563(6-methoxy-5-methyl-4-(4-phenoxyphenylamino)H-pyrro...)
Affinity DataIC50:  805nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176597(CHEMBL202545 | ethyl 4-(4-benzoylphenylamino)-3-cy...)
Affinity DataIC50:  1.11E+3nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176577(CHEMBL201246 | ethyl 3-cyano-5-methyl-4-(4-(phenyl...)
Affinity DataIC50:  2.32E+3nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176579(CHEMBL383098 | ethyl 3-cyano-5-methyl-4-(3-phenoxy...)
Affinity DataIC50:  2.65E+3nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176587(CHEMBL202128 | ethyl 5-methyl-4-(4-phenoxyphenylam...)
Affinity DataIC50:  3.47E+3nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176590(CHEMBL201780 | ethyl 3-cyano-5-methyl-4-(4-phenoxy...)
Affinity DataIC50:  5.42E+3nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176594(6-(benzylamino)-5-methyl-4-(4-phenoxyphenylamino)H...)
Affinity DataIC50:  6.13E+3nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176561(CHEMBL204147 | N-(3-cyano-5-methyl-4-(4-phenoxyphe...)
Affinity DataIC50:  1.46E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176568(CHEMBL202211 | ethyl 4-(4-(benzyloxy)phenylamino)-...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176589(5-methyl-3-(methylsulfonamidomethyl)-4-(4-phenoxyp...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176585(CHEMBL202142 | ethyl 4-(4-phenoxybenzylamino)-3-cy...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176596(4-(biphenyl-4-ylamino)-3-cyano-5-methyl-pyrrolo[1,...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176574(6-(2-hydroxypropan-2-yl)-5-methyl-4-(4-phenoxyphen...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176600(CHEMBL377497 | ethyl 3-cyano-5-methyl-4-(phenylami...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176582(3-(acetamidomethyl)-5-methyl-4-(4-phenoxyphenylami...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50176598(3-(aminomethyl)-5-methyl-4-(4-phenoxyphenylamino)H...)
Affinity DataIC50: >2.50E+4nMAssay Description:Inhibitory activity against MEKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed