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Found 26 Enz. Inhib. hit(s) with all data for entry = 50017238
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179427(2-(6-(4-(2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)p...)
Affinity DataIC50:  9nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179418(2-(6-(4-aminoazepan-1-yl)pyrimidin-4-ylamino)thiaz...)
Affinity DataIC50:  9nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179415(2-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4...)
Affinity DataIC50:  9nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179413(2-(6-(4-aminopiperidin-1-yl)pyrimidin-4-ylamino)th...)
Affinity DataIC50:  10nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179420(2-(6-(4-(3-morpholinopropyl)piperazin-1-yl)pyrimid...)
Affinity DataIC50:  10nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179417(2-(6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)t...)
Affinity DataIC50:  10nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179427(2-(6-(4-(2-(pyrrolidin-1-yl)ethyl)piperazin-1-yl)p...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179414(2-(6-(4-(2-morpholinoethyl)piperazin-1-yl)pyrimidi...)
Affinity DataIC50:  12nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179416(2-(6-(4-acetylpiperazin-1-yl)pyrimidin-4-ylamino)t...)
Affinity DataIC50:  13nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179418(2-(6-(4-aminoazepan-1-yl)pyrimidin-4-ylamino)thiaz...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179421((rac)-2-(6-(3-aminopyrrolidin-1-yl)pyrimidin-4-yla...)
Affinity DataIC50:  16nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179422(2-(6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-...)
Affinity DataIC50:  16nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179414(2-(6-(4-(2-morpholinoethyl)piperazin-1-yl)pyrimidi...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179421((rac)-2-(6-(3-aminopyrrolidin-1-yl)pyrimidin-4-yla...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179415(2-(6-(4-(2-methoxyethyl)piperazin-1-yl)pyrimidin-4...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179420(2-(6-(4-(3-morpholinopropyl)piperazin-1-yl)pyrimid...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179417(2-(6-(4-methylpiperazin-1-yl)pyrimidin-4-ylamino)t...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179423(2-(6-(1,4-diazepan-1-yl)pyrimidin-4-ylamino)thiazo...)
Affinity DataIC50:  27nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179423(2-(6-(1,4-diazepan-1-yl)pyrimidin-4-ylamino)thiazo...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179422(2-(6-(piperazin-1-yl)pyrimidin-4-ylamino)thiazole-...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179425(2-(6-aminopyrimidin-4-ylamino)thiazole-5-carbonitr...)
Affinity DataIC50:  41nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179416(2-(6-(4-acetylpiperazin-1-yl)pyrimidin-4-ylamino)t...)
Affinity DataIC50:  44nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179413(2-(6-(4-aminopiperidin-1-yl)pyrimidin-4-ylamino)th...)
Affinity DataIC50:  59nMAssay Description:Inhibition of human KDR expressed in HEK293 cells by KDR autophosphorylation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179419(2-(2-(4-acetylpiperazin-1-yl)pyrimidin-4-ylamino)t...)
Affinity DataIC50:  153nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179424(2-(2-aminopyrimidin-4-ylamino)thiazole-5-carbonitr...)
Affinity DataIC50:  557nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50179426(2-(pyrimidin-4-ylamino)thiazole-5-carbonitrile | C...)
Affinity DataIC50:  990nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed