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PubMed code 16789750

Compile data set for download or QSAR
Found 155 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189854
PNG
(6-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1
Show InChI InChI=1S/C19H21BrN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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0.25n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189841
PNG
(6-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1
Show InChI InChI=1S/C19H21IN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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0.330n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50094505
PNG
(2-((4-phenylpiperazin-1-yl)methyl)-1H-indole-5-car...)
Show SMILES N#Cc1ccc2[nH]c(CN3CCN(CC3)c3ccccc3)cc2c1
Show InChI InChI=1S/C20H20N4/c21-14-16-6-7-20-17(12-16)13-18(22-20)15-23-8-10-24(11-9-23)19-4-2-1-3-5-19/h1-7,12-13,22H,8-11,15H2
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0.520n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189852
PNG
(8-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1
Show InChI InChI=1S/C20H23IN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3
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0.530n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189843
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1
Show InChI InChI=1S/C26H28N4O/c1-20-16-23(21-8-4-3-5-9-21)26-27-22(19-30(26)17-20)18-28-12-14-29(15-13-28)24-10-6-7-11-25(24)31-2/h3-11,16-17,19H,12-15,18H2,1-2H3
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0.840n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189844
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-5-(pyr...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3c(cccc3n2)-n2cccn2)CC1
Show InChI InChI=1S/C22H24N6O/c1-29-20-7-3-2-6-19(20)26-14-12-25(13-15-26)16-18-17-27-21(24-18)8-4-9-22(27)28-11-5-10-23-28/h2-11,17H,12-16H2,1H3
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0.940n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189851
PNG
(8-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1
Show InChI InChI=1S/C20H23BrN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3
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0.990n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189839
PNG
(6-bromo-2-[4-(3,4-dichlorophenyl)piperazin-1-ylmet...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3cc(Br)ccc3n2)CC1
Show InChI InChI=1S/C18H17BrCl2N4/c19-13-1-4-18-22-14(12-25(18)10-13)11-23-5-7-24(8-6-23)15-2-3-16(20)17(21)9-15/h1-4,9-10,12H,5-8,11H2
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0.990n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50094503
PNG
(2-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-1H-in...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cc3cc(ccc3[nH]2)C#N)CC1
Show InChI InChI=1S/C20H19FN4/c21-17-2-4-19(5-3-17)25-9-7-24(8-10-25)14-18-12-16-11-15(13-22)1-6-20(16)23-18/h1-6,11-12,23H,7-10,14H2
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1n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189856
PNG
(6-chloro-2-[4-(3,4-dichlorophenyl)piperazin-1-ylme...)
Show SMILES Clc1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C17H16Cl3N5/c18-14-2-1-13(9-15(14)19)24-7-5-23(6-8-24)10-12-11-25-17(21-12)4-3-16(20)22-25/h1-4,9,11H,5-8,10H2
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1.30n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189853
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1
Show InChI InChI=1S/C21H23N5O/c1-16-11-17(12-22)21-23-18(15-26(21)13-16)14-24-7-9-25(10-8-24)19-5-3-4-6-20(19)27-2/h3-6,11,13,15H,7-10,14H2,1-2H3
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1.30n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189848
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]imid...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H18Cl2N4/c19-16-5-4-15(11-17(16)20)23-9-7-22(8-10-23)12-14-13-24-6-2-1-3-18(24)21-14/h1-6,11,13H,7-10,12H2
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1.40n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189847
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1
Show InChI InChI=1S/C23H26N6O/c1-18-14-21(29-9-5-8-24-29)23-25-19(17-28(23)15-18)16-26-10-12-27(13-11-26)20-6-3-4-7-22(20)30-2/h3-9,14-15,17H,10-13,16H2,1-2H3
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1.60n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189840
PNG
(6-chloro-2-[4-(2-methoxyphenyl)piperazin-1-ylmethy...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C18H20ClN5O/c1-25-16-5-3-2-4-15(16)23-10-8-22(9-11-23)12-14-13-24-18(20-14)7-6-17(19)21-24/h2-7,13H,8-12H2,1H3
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1.60n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189849
PNG
(6-chloro-2-[4-(4-chlorophenyl)piperazin-1-ylmethyl...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17Cl2N5/c18-13-1-3-15(4-2-13)23-9-7-22(8-10-23)11-14-12-24-17(20-14)6-5-16(19)21-24/h1-6,12H,7-11H2
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2n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189857
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1
Show InChI InChI=1S/C24H31N5O2/c1-19-15-22(28-11-13-31-14-12-28)24-25-20(18-29(24)16-19)17-26-7-9-27(10-8-26)21-5-3-4-6-23(21)30-2/h3-6,15-16,18H,7-14,17H2,1-2H3
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2.30n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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2.80n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50073805
PNG
(3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyra...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn3ccccc23)CC1
Show InChI InChI=1S/C18H19ClN4/c19-16-4-6-17(7-5-16)22-11-9-21(10-12-22)14-15-13-20-23-8-2-1-3-18(15)23/h1-8,13H,9-12,14H2
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3.60n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189846
PNG
(6-chloro-2-[4-(4-fluorophenyl)piperazin-1-ylmethyl...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17ClFN5/c18-16-5-6-17-20-14(12-24(17)21-16)11-22-7-9-23(10-8-22)15-3-1-13(19)2-4-15/h1-6,12H,7-11H2
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4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189842
PNG
(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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7n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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16n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50189840
PNG
(6-chloro-2-[4-(2-methoxyphenyl)piperazin-1-ylmethy...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C18H20ClN5O/c1-25-16-5-3-2-4-15(16)23-10-8-22(9-11-23)12-14-13-24-18(20-14)7-6-17(19)21-24/h2-7,13H,8-12H2,1H3
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24n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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28n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189843
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1
Show InChI InChI=1S/C26H28N4O/c1-20-16-23(21-8-4-3-5-9-21)26-27-22(19-30(26)17-20)18-28-12-14-29(15-13-28)24-10-6-7-11-25(24)31-2/h3-11,16-17,19H,12-15,18H2,1-2H3
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28n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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41n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189837
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19FN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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44n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189843
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1
Show InChI InChI=1S/C26H28N4O/c1-20-16-23(21-8-4-3-5-9-21)26-27-22(19-30(26)17-20)18-28-12-14-29(15-13-28)24-10-6-7-11-25(24)31-2/h3-11,16-17,19H,12-15,18H2,1-2H3
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49n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189841
PNG
(6-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1
Show InChI InChI=1S/C19H21IN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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72n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189841
PNG
(6-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1
Show InChI InChI=1S/C19H21IN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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73n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189840
PNG
(6-chloro-2-[4-(2-methoxyphenyl)piperazin-1-ylmethy...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C18H20ClN5O/c1-25-16-5-3-2-4-15(16)23-10-8-22(9-11-23)12-14-13-24-18(20-14)7-6-17(19)21-24/h2-7,13H,8-12H2,1H3
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79n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189852
PNG
(8-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1
Show InChI InChI=1S/C20H23IN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3
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88n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189840
PNG
(6-chloro-2-[4-(2-methoxyphenyl)piperazin-1-ylmethy...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C18H20ClN5O/c1-25-16-5-3-2-4-15(16)23-10-8-22(9-11-23)12-14-13-24-18(20-14)7-6-17(19)21-24/h2-7,13H,8-12H2,1H3
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96n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189852
PNG
(8-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1
Show InChI InChI=1S/C20H23IN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3
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97n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189857
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1
Show InChI InChI=1S/C24H31N5O2/c1-19-15-22(28-11-13-31-14-12-28)24-25-20(18-29(24)16-19)17-26-7-9-27(10-8-26)21-5-3-4-6-23(21)30-2/h3-6,15-16,18H,7-14,17H2,1-2H3
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100n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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110n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]7-OH-DPAT from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189855
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3nc(ccc3n2)N2CCCCC2)CC1
Show InChI InChI=1S/C22H26Cl2N6/c23-19-5-4-18(14-20(19)24)28-12-10-27(11-13-28)15-17-16-30-21(25-17)6-7-22(26-30)29-8-2-1-3-9-29/h4-7,14,16H,1-3,8-13,15H2
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120n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189854
PNG
(6-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1
Show InChI InChI=1S/C19H21BrN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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130n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189854
PNG
(6-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1
Show InChI InChI=1S/C19H21BrN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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140n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189851
PNG
(8-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1
Show InChI InChI=1S/C20H23BrN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3
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150n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189857
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1
Show InChI InChI=1S/C24H31N5O2/c1-19-15-22(28-11-13-31-14-12-28)24-25-20(18-29(24)16-19)17-26-7-9-27(10-8-26)21-5-3-4-6-23(21)30-2/h3-6,15-16,18H,7-14,17H2,1-2H3
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210n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189851
PNG
(8-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1
Show InChI InChI=1S/C20H23BrN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3
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240n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189844
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-5-(pyr...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3c(cccc3n2)-n2cccn2)CC1
Show InChI InChI=1S/C22H24N6O/c1-29-20-7-3-2-6-19(20)26-14-12-25(13-15-26)16-18-17-27-21(24-18)8-4-9-22(27)28-11-5-10-23-28/h2-11,17H,12-16H2,1H3
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280n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189847
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1
Show InChI InChI=1S/C23H26N6O/c1-18-14-21(29-9-5-8-24-29)23-25-19(17-28(23)15-18)16-26-10-12-27(13-11-26)20-6-3-4-7-22(20)30-2/h3-9,14-15,17H,10-13,16H2,1-2H3
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280n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50094505
PNG
(2-((4-phenylpiperazin-1-yl)methyl)-1H-indole-5-car...)
Show SMILES N#Cc1ccc2[nH]c(CN3CCN(CC3)c3ccccc3)cc2c1
Show InChI InChI=1S/C20H20N4/c21-14-16-6-7-20-17(12-16)13-18(22-20)15-23-8-10-24(11-9-23)19-4-2-1-3-5-19/h1-7,12-13,22H,8-11,15H2
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290n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50189856
PNG
(6-chloro-2-[4-(3,4-dichlorophenyl)piperazin-1-ylme...)
Show SMILES Clc1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C17H16Cl3N5/c18-14-2-1-13(9-15(14)19)24-7-5-23(6-8-24)10-12-11-25-17(21-12)4-3-16(20)22-25/h1-4,9,11H,5-8,10H2
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360n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50073805
PNG
(3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyra...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn3ccccc23)CC1
Show InChI InChI=1S/C18H19ClN4/c19-16-4-6-17(7-5-16)22-11-9-21(10-12-22)14-15-13-20-23-8-2-1-3-18(15)23/h1-8,13H,9-12,14H2
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380n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2 receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189843
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1
Show InChI InChI=1S/C26H28N4O/c1-20-16-23(21-8-4-3-5-9-21)26-27-22(19-30(26)17-20)18-28-12-14-29(15-13-28)24-10-6-7-11-25(24)31-2/h3-11,16-17,19H,12-15,18H2,1-2H3
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390n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50189849
PNG
(6-chloro-2-[4-(4-chlorophenyl)piperazin-1-ylmethyl...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17Cl2N5/c18-13-1-3-15(4-2-13)23-9-7-22(8-10-23)11-14-12-24-17(20-14)6-5-16(19)21-24/h1-6,12H,7-11H2
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390n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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400n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]7-OH-DPAT from porcine dopamine receptor D2


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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420n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189852
PNG
(8-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1
Show InChI InChI=1S/C20H23IN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3
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470n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189838
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccncc3n2)CC1
Show InChI InChI=1S/C17H18FN5/c18-14-1-3-16(4-2-14)22-9-7-21(8-10-22)12-15-13-23-6-5-19-11-17(23)20-15/h1-6,11,13H,7-10,12H2
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500n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189847
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1
Show InChI InChI=1S/C23H26N6O/c1-18-14-21(29-9-5-8-24-29)23-25-19(17-28(23)15-18)16-26-10-12-27(13-11-26)20-6-3-4-7-22(20)30-2/h3-9,14-15,17H,10-13,16H2,1-2H3
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530n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189844
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-5-(pyr...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3c(cccc3n2)-n2cccn2)CC1
Show InChI InChI=1S/C22H24N6O/c1-29-20-7-3-2-6-19(20)26-14-12-25(13-15-26)16-18-17-27-21(24-18)8-4-9-22(27)28-11-5-10-23-28/h2-11,17H,12-16H2,1H3
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590n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189841
PNG
(6-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1
Show InChI InChI=1S/C19H21IN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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600n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189856
PNG
(6-chloro-2-[4-(3,4-dichlorophenyl)piperazin-1-ylme...)
Show SMILES Clc1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C17H16Cl3N5/c18-14-2-1-13(9-15(14)19)24-7-5-23(6-8-24)10-12-11-25-17(21-12)4-3-16(20)22-25/h1-4,9,11H,5-8,10H2
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670n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189851
PNG
(8-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1
Show InChI InChI=1S/C20H23BrN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3
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670n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189855
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3nc(ccc3n2)N2CCCCC2)CC1
Show InChI InChI=1S/C22H26Cl2N6/c23-19-5-4-18(14-20(19)24)28-12-10-27(11-13-28)15-17-16-30-21(25-17)6-7-22(26-30)29-8-2-1-3-9-29/h4-7,14,16H,1-3,8-13,15H2
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710n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189854
PNG
(6-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1
Show InChI InChI=1S/C19H21BrN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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800n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189855
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3nc(ccc3n2)N2CCCCC2)CC1
Show InChI InChI=1S/C22H26Cl2N6/c23-19-5-4-18(14-20(19)24)28-12-10-27(11-13-28)15-17-16-30-21(25-17)6-7-22(26-30)29-8-2-1-3-9-29/h4-7,14,16H,1-3,8-13,15H2
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850n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50189837
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19FN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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860n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2 receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189850
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(...)
Show SMILES CN1CCN(CC1)c1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C22H27Cl2N7/c1-27-6-10-30(11-7-27)22-5-4-21-25-17(16-31(21)26-22)15-28-8-12-29(13-9-28)18-2-3-19(23)20(24)14-18/h2-5,14,16H,6-13,15H2,1H3
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880n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50189849
PNG
(6-chloro-2-[4-(4-chlorophenyl)piperazin-1-ylmethyl...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17Cl2N5/c18-13-1-3-15(4-2-13)23-9-7-22(8-10-23)11-14-12-24-17(20-14)6-5-16(19)21-24/h1-6,12H,7-11H2
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910n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2 receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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930n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50001884
PNG
(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
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960n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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990n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189844
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-5-(pyr...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3c(cccc3n2)-n2cccn2)CC1
Show InChI InChI=1S/C22H24N6O/c1-29-20-7-3-2-6-19(20)26-14-12-25(13-15-26)16-18-17-27-21(24-18)8-4-9-22(27)28-11-5-10-23-28/h2-11,17H,12-16H2,1H3
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1.00E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189839
PNG
(6-bromo-2-[4-(3,4-dichlorophenyl)piperazin-1-ylmet...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3cc(Br)ccc3n2)CC1
Show InChI InChI=1S/C18H17BrCl2N4/c19-13-1-4-18-22-14(12-25(18)10-13)11-23-5-7-24(8-6-23)15-2-3-16(20)17(21)9-15/h1-4,9-10,12H,5-8,11H2
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1.00E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189856
PNG
(6-chloro-2-[4-(3,4-dichlorophenyl)piperazin-1-ylme...)
Show SMILES Clc1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C17H16Cl3N5/c18-14-2-1-13(9-15(14)19)24-7-5-23(6-8-24)10-12-11-25-17(21-12)4-3-16(20)22-25/h1-4,9,11H,5-8,10H2
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1.10E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189855
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3nc(ccc3n2)N2CCCCC2)CC1
Show InChI InChI=1S/C22H26Cl2N6/c23-19-5-4-18(14-20(19)24)28-12-10-27(11-13-28)15-17-16-30-21(25-17)6-7-22(26-30)29-8-2-1-3-9-29/h4-7,14,16H,1-3,8-13,15H2
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1.10E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50189848
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]imid...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H18Cl2N4/c19-16-5-4-15(11-17(16)20)23-9-7-22(8-10-23)12-14-13-24-6-2-1-3-18(24)21-14/h1-6,11,13H,7-10,12H2
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1.20E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2 receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50189856
PNG
(6-chloro-2-[4-(3,4-dichlorophenyl)piperazin-1-ylme...)
Show SMILES Clc1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C17H16Cl3N5/c18-14-2-1-13(9-15(14)19)24-7-5-23(6-8-24)10-12-11-25-17(21-12)4-3-16(20)22-25/h1-4,9,11H,5-8,10H2
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1.20E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2 receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50189842
PNG
(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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1.20E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2 receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189840
PNG
(6-chloro-2-[4-(2-methoxyphenyl)piperazin-1-ylmethy...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C18H20ClN5O/c1-25-16-5-3-2-4-15(16)23-10-8-22(9-11-23)12-14-13-24-18(20-14)7-6-17(19)21-24/h2-7,13H,8-12H2,1H3
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1.40E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50073805
PNG
(3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyra...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn3ccccc23)CC1
Show InChI InChI=1S/C18H19ClN4/c19-16-4-6-17(7-5-16)22-11-9-21(10-12-22)14-15-13-20-23-8-2-1-3-18(15)23/h1-8,13H,9-12,14H2
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1.40E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189856
PNG
(6-chloro-2-[4-(3,4-dichlorophenyl)piperazin-1-ylme...)
Show SMILES Clc1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C17H16Cl3N5/c18-14-2-1-13(9-15(14)19)24-7-5-23(6-8-24)10-12-11-25-17(21-12)4-3-16(20)22-25/h1-4,9,11H,5-8,10H2
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1.50E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189856
PNG
(6-chloro-2-[4-(3,4-dichlorophenyl)piperazin-1-ylme...)
Show SMILES Clc1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C17H16Cl3N5/c18-14-2-1-13(9-15(14)19)24-7-5-23(6-8-24)10-12-11-25-17(21-12)4-3-16(20)22-25/h1-4,9,11H,5-8,10H2
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1.50E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189848
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]imid...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H18Cl2N4/c19-16-5-4-15(11-17(16)20)23-9-7-22(8-10-23)12-14-13-24-6-2-1-3-18(24)21-14/h1-6,11,13H,7-10,12H2
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1.70E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50094505
PNG
(2-((4-phenylpiperazin-1-yl)methyl)-1H-indole-5-car...)
Show SMILES N#Cc1ccc2[nH]c(CN3CCN(CC3)c3ccccc3)cc2c1
Show InChI InChI=1S/C20H20N4/c21-14-16-6-7-20-17(12-16)13-18(22-20)15-23-8-10-24(11-9-23)19-4-2-1-3-5-19/h1-7,12-13,22H,8-11,15H2
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1.70E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50189842
PNG
(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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1.70E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189850
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(...)
Show SMILES CN1CCN(CC1)c1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C22H27Cl2N7/c1-27-6-10-30(11-7-27)22-5-4-21-25-17(16-31(21)26-22)15-28-8-12-29(13-9-28)18-2-3-19(23)20(24)14-18/h2-5,14,16H,6-13,15H2,1H3
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1.90E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189857
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1
Show InChI InChI=1S/C24H31N5O2/c1-19-15-22(28-11-13-31-14-12-28)24-25-20(18-29(24)16-19)17-26-7-9-27(10-8-26)21-5-3-4-6-23(21)30-2/h3-6,15-16,18H,7-14,17H2,1-2H3
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2.10E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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2.20E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189855
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3nc(ccc3n2)N2CCCCC2)CC1
Show InChI InChI=1S/C22H26Cl2N6/c23-19-5-4-18(14-20(19)24)28-12-10-27(11-13-28)15-17-16-30-21(25-17)6-7-22(26-30)29-8-2-1-3-9-29/h4-7,14,16H,1-3,8-13,15H2
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2.20E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189848
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]imid...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H18Cl2N4/c19-16-5-4-15(11-17(16)20)23-9-7-22(8-10-23)12-14-13-24-6-2-1-3-18(24)21-14/h1-6,11,13H,7-10,12H2
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2.30E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50189848
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]imid...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H18Cl2N4/c19-16-5-4-15(11-17(16)20)23-9-7-22(8-10-23)12-14-13-24-6-2-1-3-18(24)21-14/h1-6,11,13H,7-10,12H2
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2.30E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189847
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1
Show InChI InChI=1S/C23H26N6O/c1-18-14-21(29-9-5-8-24-29)23-25-19(17-28(23)15-18)16-26-10-12-27(13-11-26)20-6-3-4-7-22(20)30-2/h3-9,14-15,17H,10-13,16H2,1-2H3
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2.40E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189839
PNG
(6-bromo-2-[4-(3,4-dichlorophenyl)piperazin-1-ylmet...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3cc(Br)ccc3n2)CC1
Show InChI InChI=1S/C18H17BrCl2N4/c19-13-1-4-18-22-14(12-25(18)10-13)11-23-5-7-24(8-6-23)15-2-3-16(20)17(21)9-15/h1-4,9-10,12H,5-8,11H2
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2.50E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189853
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1
Show InChI InChI=1S/C21H23N5O/c1-16-11-17(12-22)21-23-18(15-26(21)13-16)14-24-7-9-25(10-8-24)19-5-3-4-6-20(19)27-2/h3-6,11,13,15H,7-10,14H2,1-2H3
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2.70E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189848
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]imid...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H18Cl2N4/c19-16-5-4-15(11-17(16)20)23-9-7-22(8-10-23)12-14-13-24-6-2-1-3-18(24)21-14/h1-6,11,13H,7-10,12H2
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2.70E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189836
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3cccnc3n2)CC1
Show InChI InChI=1S/C17H18FN5/c18-14-2-4-16(5-3-14)22-10-8-21(9-11-22)12-15-13-23-7-1-6-19-17(23)20-15/h1-7,13H,8-12H2
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2.80E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D4.4 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189843
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-c4ccccc4)c3n2)CC1
Show InChI InChI=1S/C26H28N4O/c1-20-16-23(21-8-4-3-5-9-21)26-27-22(19-30(26)17-20)18-28-12-14-29(15-13-28)24-10-6-7-11-25(24)31-2/h3-11,16-17,19H,12-15,18H2,1-2H3
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2.90E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50094505
PNG
(2-((4-phenylpiperazin-1-yl)methyl)-1H-indole-5-car...)
Show SMILES N#Cc1ccc2[nH]c(CN3CCN(CC3)c3ccccc3)cc2c1
Show InChI InChI=1S/C20H20N4/c21-14-16-6-7-20-17(12-16)13-18(22-20)15-23-8-10-24(11-9-23)19-4-2-1-3-5-19/h1-7,12-13,22H,8-11,15H2
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3.10E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189837
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19FN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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3.10E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189848
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]imid...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H18Cl2N4/c19-16-5-4-15(11-17(16)20)23-9-7-22(8-10-23)12-14-13-24-6-2-1-3-18(24)21-14/h1-6,11,13H,7-10,12H2
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3.20E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50073805
PNG
(3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyra...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn3ccccc23)CC1
Show InChI InChI=1S/C18H19ClN4/c19-16-4-6-17(7-5-16)22-11-9-21(10-12-22)14-15-13-20-23-8-2-1-3-18(15)23/h1-8,13H,9-12,14H2
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3.20E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50189840
PNG
(6-chloro-2-[4-(2-methoxyphenyl)piperazin-1-ylmethy...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C18H20ClN5O/c1-25-16-5-3-2-4-15(16)23-10-8-22(9-11-23)12-14-13-24-18(20-14)7-6-17(19)21-24/h2-7,13H,8-12H2,1H3
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3.40E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2 receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189853
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1
Show InChI InChI=1S/C21H23N5O/c1-16-11-17(12-22)21-23-18(15-26(21)13-16)14-24-7-9-25(10-8-24)19-5-3-4-6-20(19)27-2/h3-6,11,13,15H,7-10,14H2,1-2H3
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3.50E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189839
PNG
(6-bromo-2-[4-(3,4-dichlorophenyl)piperazin-1-ylmet...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3cc(Br)ccc3n2)CC1
Show InChI InChI=1S/C18H17BrCl2N4/c19-13-1-4-18-22-14(12-25(18)10-13)11-23-5-7-24(8-6-23)15-2-3-16(20)17(21)9-15/h1-4,9-10,12H,5-8,11H2
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3.50E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-hydroxytryptamine receptor 1A (5-HT1A)


(Homo sapiens (Human))
BDBM50189837
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19FN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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3.60E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]8-OH-DPAT from 5HT1A receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189839
PNG
(6-bromo-2-[4-(3,4-dichlorophenyl)piperazin-1-ylmet...)
Show SMILES Clc1ccc(cc1Cl)N1CCN(Cc2cn3cc(Br)ccc3n2)CC1
Show InChI InChI=1S/C18H17BrCl2N4/c19-13-1-4-18-22-14(12-25(18)10-13)11-23-5-7-24(8-6-23)15-2-3-16(20)17(21)9-15/h1-4,9-10,12H,5-8,11H2
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3.70E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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3.90E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189853
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1
Show InChI InChI=1S/C21H23N5O/c1-16-11-17(12-22)21-23-18(15-26(21)13-16)14-24-7-9-25(10-8-24)19-5-3-4-6-20(19)27-2/h3-6,11,13,15H,7-10,14H2,1-2H3
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4.20E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50073805
PNG
(3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyra...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn3ccccc23)CC1
Show InChI InChI=1S/C18H19ClN4/c19-16-4-6-17(7-5-16)22-11-9-21(10-12-22)14-15-13-20-23-8-2-1-3-18(15)23/h1-8,13H,9-12,14H2
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4.30E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50073805
PNG
(3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyra...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn3ccccc23)CC1
Show InChI InChI=1S/C18H19ClN4/c19-16-4-6-17(7-5-16)22-11-9-21(10-12-22)14-15-13-20-23-8-2-1-3-18(15)23/h1-8,13H,9-12,14H2
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5.00E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189849
PNG
(6-chloro-2-[4-(4-chlorophenyl)piperazin-1-ylmethyl...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17Cl2N5/c18-13-1-3-15(4-2-13)23-9-7-22(8-10-23)11-14-12-24-17(20-14)6-5-16(19)21-24/h1-6,12H,7-11H2
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5.50E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189846
PNG
(6-chloro-2-[4-(4-fluorophenyl)piperazin-1-ylmethyl...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17ClFN5/c18-16-5-6-17-20-14(12-24(17)21-16)11-22-7-9-23(10-8-22)15-3-1-13(19)2-4-15/h1-6,12H,7-11H2
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5.60E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189851
PNG
(8-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(Br)c3n2)CC1
Show InChI InChI=1S/C20H23BrN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3
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5.60E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
5-HT2


(PIG)
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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5.90E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]ketanserin from 5HT2 receptor in porcine cortical membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189852
PNG
(8-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(I)c3n2)CC1
Show InChI InChI=1S/C20H23IN4O/c1-15-11-17(21)20-22-16(14-25(20)12-15)13-23-7-9-24(10-8-23)18-5-3-4-6-19(18)26-2/h3-6,11-12,14H,7-10,13H2,1-2H3
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5.90E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189857
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(N4CCOCC4)c3n2)CC1
Show InChI InChI=1S/C24H31N5O2/c1-19-15-22(28-11-13-31-14-12-28)24-25-20(18-29(24)16-19)17-26-7-9-27(10-8-26)21-5-3-4-6-23(21)30-2/h3-6,15-16,18H,7-14,17H2,1-2H3
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6.40E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189841
PNG
(6-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1
Show InChI InChI=1S/C19H21IN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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6.40E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189842
PNG
(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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6.70E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189846
PNG
(6-chloro-2-[4-(4-fluorophenyl)piperazin-1-ylmethyl...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17ClFN5/c18-16-5-6-17-20-14(12-24(17)21-16)11-22-7-9-23(10-8-22)15-3-1-13(19)2-4-15/h1-6,12H,7-11H2
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7.00E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189854
PNG
(6-bromo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(Br)ccc3n2)CC1
Show InChI InChI=1S/C19H21BrN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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7.10E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189849
PNG
(6-chloro-2-[4-(4-chlorophenyl)piperazin-1-ylmethyl...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17Cl2N5/c18-13-1-3-15(4-2-13)23-9-7-22(8-10-23)11-14-12-24-17(20-14)6-5-16(19)21-24/h1-6,12H,7-11H2
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7.70E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189840
PNG
(6-chloro-2-[4-(2-methoxyphenyl)piperazin-1-ylmethy...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C18H20ClN5O/c1-25-16-5-3-2-4-15(16)23-10-8-22(9-11-23)12-14-13-24-18(20-14)7-6-17(19)21-24/h2-7,13H,8-12H2,1H3
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7.70E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189850
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(...)
Show SMILES CN1CCN(CC1)c1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C22H27Cl2N7/c1-27-6-10-30(11-7-27)22-5-4-21-25-17(16-31(21)26-22)15-28-8-12-29(13-9-28)18-2-3-19(23)20(24)14-18/h2-5,14,16H,6-13,15H2,1H3
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7.80E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189850
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(...)
Show SMILES CN1CCN(CC1)c1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C22H27Cl2N7/c1-27-6-10-30(11-7-27)22-5-4-21-25-17(16-31(21)26-22)15-28-8-12-29(13-9-28)18-2-3-19(23)20(24)14-18/h2-5,14,16H,6-13,15H2,1H3
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8.00E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189849
PNG
(6-chloro-2-[4-(4-chlorophenyl)piperazin-1-ylmethyl...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17Cl2N5/c18-13-1-3-15(4-2-13)23-9-7-22(8-10-23)11-14-12-24-17(20-14)6-5-16(19)21-24/h1-6,12H,7-11H2
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8.20E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189837
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19FN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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8.40E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50094503
PNG
(2-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-1H-in...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cc3cc(ccc3[nH]2)C#N)CC1
Show InChI InChI=1S/C20H19FN4/c21-17-2-4-19(5-3-17)25-9-7-24(8-10-25)14-18-12-16-11-15(13-22)1-6-20(16)23-18/h1-6,11-12,23H,7-10,14H2
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8.60E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189847
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(-n4cccn4)c3n2)CC1
Show InChI InChI=1S/C23H26N6O/c1-18-14-21(29-9-5-8-24-29)23-25-19(17-28(23)15-18)16-26-10-12-27(13-11-26)20-6-3-4-7-22(20)30-2/h3-9,14-15,17H,10-13,16H2,1-2H3
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8.70E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189842
PNG
(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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8.80E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189846
PNG
(6-chloro-2-[4-(4-fluorophenyl)piperazin-1-ylmethyl...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17ClFN5/c18-16-5-6-17-20-14(12-24(17)21-16)11-22-7-9-23(10-8-22)15-3-1-13(19)2-4-15/h1-6,12H,7-11H2
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9.90E+3n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189849
PNG
(6-chloro-2-[4-(4-chlorophenyl)piperazin-1-ylmethyl...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17Cl2N5/c18-13-1-3-15(4-2-13)23-9-7-22(8-10-23)11-14-12-24-17(20-14)6-5-16(19)21-24/h1-6,12H,7-11H2
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1.20E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189846
PNG
(6-chloro-2-[4-(4-fluorophenyl)piperazin-1-ylmethyl...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3nc(Cl)ccc3n2)CC1
Show InChI InChI=1S/C17H17ClFN5/c18-16-5-6-17-20-14(12-24(17)21-16)11-22-7-9-23(10-8-22)15-3-1-13(19)2-4-15/h1-6,12H,7-11H2
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1.20E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50073805
PNG
(3-((4-(4-chlorophenyl)piperazin-1-yl)methyl)H-pyra...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cnn3ccccc23)CC1
Show InChI InChI=1S/C18H19ClN4/c19-16-4-6-17(7-5-16)22-11-9-21(10-12-22)14-15-13-20-23-8-2-1-3-18(15)23/h1-8,13H,9-12,14H2
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1.20E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189850
PNG
(2-[4-(3,4-dichlorophenyl)piperazin-1-ylmethyl]-6-(...)
Show SMILES CN1CCN(CC1)c1ccc2nc(CN3CCN(CC3)c3ccc(Cl)c(Cl)c3)cn2n1
Show InChI InChI=1S/C22H27Cl2N7/c1-27-6-10-30(11-7-27)22-5-4-21-25-17(16-31(21)26-22)15-28-8-12-29(13-9-28)18-2-3-19(23)20(24)14-18/h2-5,14,16H,6-13,15H2,1H3
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1.30E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50094505
PNG
(2-((4-phenylpiperazin-1-yl)methyl)-1H-indole-5-car...)
Show SMILES N#Cc1ccc2[nH]c(CN3CCN(CC3)c3ccccc3)cc2c1
Show InChI InChI=1S/C20H20N4/c21-14-16-6-7-20-17(12-16)13-18(22-20)15-23-8-10-24(11-9-23)19-4-2-1-3-5-19/h1-7,12-13,22H,8-11,15H2
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1.30E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189838
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccncc3n2)CC1
Show InChI InChI=1S/C17H18FN5/c18-14-1-3-16(4-2-14)22-9-7-21(8-10-22)12-15-13-23-6-5-19-11-17(23)20-15/h1-6,11,13H,7-10,12H2
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1.50E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50094503
PNG
(2-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-1H-in...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cc3cc(ccc3[nH]2)C#N)CC1
Show InChI InChI=1S/C20H19FN4/c21-17-2-4-19(5-3-17)25-9-7-24(8-10-25)14-18-12-16-11-15(13-22)1-6-20(16)23-18/h1-6,11-12,23H,7-10,14H2
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1.50E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189842
PNG
(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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1.50E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189842
PNG
(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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1.60E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189837
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19FN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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1.90E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50094503
PNG
(2-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-1H-in...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cc3cc(ccc3[nH]2)C#N)CC1
Show InChI InChI=1S/C20H19FN4/c21-17-2-4-19(5-3-17)25-9-7-24(8-10-25)14-18-12-16-11-15(13-22)1-6-20(16)23-18/h1-6,11-12,23H,7-10,14H2
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1.90E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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2.00E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189837
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19FN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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2.10E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189844
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-5-(pyr...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3c(cccc3n2)-n2cccn2)CC1
Show InChI InChI=1S/C22H24N6O/c1-29-20-7-3-2-6-19(20)26-14-12-25(13-15-26)16-18-17-27-21(24-18)8-4-9-22(27)28-11-5-10-23-28/h2-11,17H,12-16H2,1H3
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2.70E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50094503
PNG
(2-((4-(4-fluorophenyl)piperazin-1-yl)methyl)-1H-in...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cc3cc(ccc3[nH]2)C#N)CC1
Show InChI InChI=1S/C20H19FN4/c21-17-2-4-19(5-3-17)25-9-7-24(8-10-25)14-18-12-16-11-15(13-22)1-6-20(16)23-18/h1-6,11-12,23H,7-10,14H2
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2.80E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189853
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]-6-meth...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(C)cc(C#N)c3n2)CC1
Show InChI InChI=1S/C21H23N5O/c1-16-11-17(12-22)21-23-18(15-26(21)13-16)14-24-7-9-25(10-8-24)19-5-3-4-6-20(19)27-2/h3-6,11,13,15H,7-10,14H2,1-2H3
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4.00E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189838
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccncc3n2)CC1
Show InChI InChI=1S/C17H18FN5/c18-14-1-3-16(4-2-14)22-9-7-21(8-10-22)12-15-13-23-6-5-19-11-17(23)20-15/h1-6,11,13H,7-10,12H2
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4.20E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine D1 receptor


(Sus scrofa)
BDBM50189836
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3cccnc3n2)CC1
Show InChI InChI=1S/C17H18FN5/c18-14-2-4-16(5-3-14)22-10-8-21(9-11-22)12-15-13-23-7-1-6-19-17(23)20-15/h1-7,13H,8-12H2
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4.70E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]SCH 23990 from dopamine receptor D1 in porcine striatal membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189836
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3cccnc3n2)CC1
Show InChI InChI=1S/C17H18FN5/c18-14-2-4-16(5-3-14)22-10-8-21(9-11-22)12-15-13-23-7-1-6-19-17(23)20-15/h1-7,13H,8-12H2
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4.90E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189836
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3cccnc3n2)CC1
Show InChI InChI=1S/C17H18FN5/c18-14-2-4-16(5-3-14)22-10-8-21(9-11-22)12-15-13-23-7-1-6-19-17(23)20-15/h1-7,13H,8-12H2
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5.50E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(3) dopamine receptor


(Homo sapiens (Human))
BDBM50189836
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3cccnc3n2)CC1
Show InChI InChI=1S/C17H18FN5/c18-14-2-4-16(5-3-14)22-10-8-21(9-11-22)12-15-13-23-7-1-6-19-17(23)20-15/h1-7,13H,8-12H2
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6.00E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D3 in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189838
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccncc3n2)CC1
Show InChI InChI=1S/C17H18FN5/c18-14-1-3-16(4-2-14)22-9-7-21(8-10-22)12-15-13-23-6-5-19-11-17(23)20-15/h1-6,11,13H,7-10,12H2
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6.40E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(long) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
D(2) dopamine receptor


(Homo sapiens (Human))
BDBM50189838
PNG
(2-[4-(4-fluorophenyl)piperazin-1-ylmethyl]imidazo[...)
Show SMILES Fc1ccc(cc1)N1CCN(Cc2cn3ccncc3n2)CC1
Show InChI InChI=1S/C17H18FN5/c18-14-1-3-16(4-2-14)22-9-7-21(8-10-22)12-15-13-23-6-5-19-11-17(23)20-15/h1-6,11,13H,7-10,12H2
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6.80E+4n/an/an/an/an/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Displacement of [3H]spiperone from human dopamine receptor D2(short) in CHO cell membrane


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM84637
PNG
(CAS_85760-74-3 | CHEMBL240773 | NSC_54562 | QUINPI...)
Show SMILES CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@@H]12
Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
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n/an/an/an/a 1.40n/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Activity at human D4.2 receptor assessed as [3H]thymidine incorporation in CHO 10001 cells by mitogenesis assay


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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n/an/an/an/a 4.5n/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Activity at human D4.4 receptor expressed in CHOK1 cells assessed as stimulation of [35S]GTP-gammaS binding


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189842
PNG
(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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n/an/an/an/a 1.80n/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Activity at human D4.2 receptor assessed as [3H]thymidine incorporation in CHO 10001 cells by mitogenesis assay


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM84637
PNG
(CAS_85760-74-3 | CHEMBL240773 | NSC_54562 | QUINPI...)
Show SMILES CCCN1CCC[C@@H]2Cc3[nH]ncc3C[C@@H]12
Show InChI InChI=1S/C13H21N3/c1-2-5-16-6-3-4-10-7-12-11(8-13(10)16)9-14-15-12/h9-10,13H,2-8H2,1H3,(H,14,15)/t10-,13-/m1/s1
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n/an/an/an/a 49n/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Activity at human D4.4 receptor expressed in CHOK1 cells assessed as stimulation of [35S]GTP-gammaS binding


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189842
PNG
(2-[4-(4-chlorophenyl)piperazin-1-yl)methyl]imidazo...)
Show SMILES Clc1ccc(cc1)N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C18H19ClN4/c19-15-4-6-17(7-5-15)22-11-9-21(10-12-22)13-16-14-23-8-2-1-3-18(23)20-16/h1-8,14H,9-13H2
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n/an/an/an/a 2.60n/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Activity at human D4.4 receptor expressed in CHOK1 cells assessed as stimulation of [35S]GTP-gammaS binding


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189845
PNG
(2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]imidazo...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3ccccc3n2)CC1
Show InChI InChI=1S/C19H22N4O/c1-24-18-7-3-2-6-17(18)22-12-10-21(11-13-22)14-16-15-23-9-5-4-8-19(23)20-16/h2-9,15H,10-14H2,1H3
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n/an/an/an/a 3n/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Activity at human D4.2 receptor assessed as [3H]thymidine incorporation in CHO 10001 cells by mitogenesis assay


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
Dopamine receptors; D2 & D4


(Homo sapiens (Human))
BDBM50189841
PNG
(6-iodo-2-[4-(2-methoxyphenyl)piperazin-1-ylmethyl]...)
Show SMILES COc1ccccc1N1CCN(Cc2cn3cc(I)ccc3n2)CC1
Show InChI InChI=1S/C19H21IN4O/c1-25-18-5-3-2-4-17(18)23-10-8-22(9-11-23)13-16-14-24-12-15(20)6-7-19(24)21-16/h2-7,12,14H,8-11,13H2,1H3
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n/an/an/an/a 0.520n/an/an/an/a



Laboratoire de Chimie Th�rapeutique

Curated by ChEMBL


Assay Description
Activity at human D4.2 receptor assessed as [3H]thymidine incorporation in CHO 10001 cells by mitogenesis assay


J Med Chem 49: 3938-47 (2006)


Article DOI: 10.1021/jm060166w
BindingDB Entry DOI: 10.7270/Q20G3KZ5
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%