Compile Data Set for Download or QSAR
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Found 16 Enz. Inhib. hit(s) with all data for entry = 3176
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Affinity DataIC50:  1.49E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Affinity DataIC50:  1.49E+5nM Kd:  1.54E+5nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29017((1S,5S,7R)-N-hydroxy-3-[(4-phenylphenyl)methyl]-6,...)
Affinity DataIC50:  3.99E+5nM Kd: >5.00E+5nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29016((1R,5S,7R)-N-hydroxy-2-oxo-3-[(4-phenylphenyl)meth...)
Affinity DataIC50:  4.25E+5nM Kd: >5.00E+5nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Affinity DataIC50:  5.13E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Affinity DataIC50:  7.78E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29015((1S,5S,7R)-3-[(4-phenylphenyl)methyl]-6,8-dioxa-3-...)
Affinity DataIC50:  8.35E+5nM Kd: >1.00E+6nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-2(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Affinity DataIC50:  8.65E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29014((1R,5S,7R)-2-oxo-3-[(4-phenylphenyl)methyl]-6,8-di...)
Affinity DataIC50:  9.54E+5nM Kd: >1.00E+6nMpH: 7.0 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Affinity DataIC50:  1.18E+6nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Affinity DataIC50:  1.51E+6nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29023((1S,5R)-3-[(4-phenylphenyl)methyl]-6,8-dioxa-3-aza...)
Affinity DatapH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29020((1S,5S,7R)-3-benzyl-6,8-dioxa-3-azabicyclo[3.2.1]o...)
Affinity DataKd: >1.00E+7nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29022(ethyl 1-(hydroxycarbamoyl)piperidine-4-carboxylate...)
Affinity DataKd:  3.40E+6nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29021((1R,5S,7R)-3-benzyl-N-hydroxy-2-oxo-6,8-dioxa-3-az...)
Affinity DataKd: >1.00E+7nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMacrophage metalloelastase(Homo sapiens (Human))
University Of Florence

LigandPNGBDBM29019((1R,5S,7R)-3-benzyl-2-oxo-6,8-dioxa-3-azabicyclo[3...)
Affinity DataKd: >1.00E+7nMpH: 7.2 T: 2°CAssay Description:The NMR experiments were performed to determine the binding affinity (KD) for the MMP-12 catalytic domain. The alteration of the chemical shifts indu...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed