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PubMed code 16908145

Compile data set for download or QSAR
Found 14 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370782
PNG
(CHEMBL222115)
Show SMILES OC(=O)c1cnn(c1)-c1ccc(COCc2ccc(cc2)-c2ccccc2C#N)cn1
Show InChI InChI=1S/C24H18N4O3/c25-11-20-3-1-2-4-22(20)19-8-5-17(6-9-19)15-31-16-18-7-10-23(26-12-18)28-14-21(13-27-28)24(29)30/h1-10,12-14H,15-16H2,(H,29,30)
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n/an/a 190n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370784
PNG
(CHEMBL221012)
Show SMILES OC(=O)c1cnn(c1)-c1ccc(COCc2ccc(Cl)cc2)cn1
Show InChI InChI=1S/C17H14ClN3O3/c18-15-4-1-12(2-5-15)10-24-11-13-3-6-16(19-7-13)21-9-14(8-20-21)17(22)23/h1-9H,10-11H2,(H,22,23)
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n/an/a 580n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50193145
PNG
(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Show SMILES OC(=O)CNC(=O)c1nc(Cl)c2ccccc2c1O
Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17)
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n/an/a 1.40E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370793
PNG
(CHEMBL218070)
Show SMILES OC(=O)c1cnn(c1)-c1ccc(COCc2ccc(cc2)C#N)cn1
Show InChI InChI=1S/C18H14N4O3/c19-7-13-1-3-14(4-2-13)11-25-12-15-5-6-17(20-8-15)22-10-16(9-21-22)18(23)24/h1-6,8-10H,11-12H2,(H,23,24)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370787
PNG
(CHEMBL269093)
Show SMILES COc1cccc(COCc2ccc(nc2)-n2cc(cn2)C(O)=O)c1
Show InChI InChI=1S/C18H17N3O4/c1-24-16-4-2-3-13(7-16)11-25-12-14-5-6-17(19-8-14)21-10-15(9-20-21)18(22)23/h2-10H,11-12H2,1H3,(H,22,23)
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n/an/a 1.60E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370786
PNG
(CHEMBL221241)
Show SMILES CC(C)c1ccc(COCc2ccc(nc2)-n2cc(cn2)C(O)=O)cc1
Show InChI InChI=1S/C20H21N3O3/c1-14(2)17-6-3-15(4-7-17)12-26-13-16-5-8-19(21-9-16)23-11-18(10-22-23)20(24)25/h3-11,14H,12-13H2,1-2H3,(H,24,25)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370789
PNG
(CHEMBL221013)
Show SMILES OC(=O)c1cnn(c1)-c1ccc(COCc2cccc(Cl)c2)cn1
Show InChI InChI=1S/C17H14ClN3O3/c18-15-3-1-2-12(6-15)10-24-11-13-4-5-16(19-7-13)21-9-14(8-20-21)17(22)23/h1-9H,10-11H2,(H,22,23)
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n/an/a 1.70E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370790
PNG
(CHEMBL218424)
Show SMILES Cc1cccc(COCc2ccc(nc2)-n2cc(cn2)C(O)=O)c1
Show InChI InChI=1S/C18H17N3O3/c1-13-3-2-4-14(7-13)11-24-12-15-5-6-17(19-8-15)21-10-16(9-20-21)18(22)23/h2-10H,11-12H2,1H3,(H,22,23)
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n/an/a 2.10E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370788
PNG
(CHEMBL375008)
Show SMILES OC(=O)c1cnn(c1)-c1ccc(COCc2ccccc2Cl)cn1
Show InChI InChI=1S/C17H14ClN3O3/c18-15-4-2-1-3-13(15)11-24-10-12-5-6-16(19-7-12)21-9-14(8-20-21)17(22)23/h1-9H,10-11H2,(H,22,23)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370792
PNG
(CHEMBL222114)
Show SMILES COc1ccc(COCc2ccc(nc2)-n2cc(cn2)C(O)=O)cc1
Show InChI InChI=1S/C18H17N3O4/c1-24-16-5-2-13(3-6-16)11-25-12-14-4-7-17(19-8-14)21-10-15(9-20-21)18(22)23/h2-10H,11-12H2,1H3,(H,22,23)
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n/an/a 2.40E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370791
PNG
(CHEMBL221189)
Show SMILES OC(=O)c1cnn(c1)-c1ccc(COCc2ccccc2)cn1
Show InChI InChI=1S/C17H15N3O3/c21-17(22)15-9-19-20(10-15)16-7-6-14(8-18-16)12-23-11-13-4-2-1-3-5-13/h1-10H,11-12H2,(H,21,22)
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n/an/a 2.70E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370781
PNG
(CHEMBL374147)
Show SMILES COc1cc(COCc2ccc(nc2)-n2cc(cn2)C(O)=O)cc(OC)c1
Show InChI InChI=1S/C19H19N3O5/c1-25-16-5-14(6-17(7-16)26-2)12-27-11-13-3-4-18(20-8-13)22-10-15(9-21-22)19(23)24/h3-10H,11-12H2,1-2H3,(H,23,24)
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n/an/a 2.80E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370783
PNG
(CHEMBL386421)
Show SMILES OC(=O)c1cnn(c1)-c1ccc(COCc2cccc(c2)C(F)(F)F)cn1
Show InChI InChI=1S/C18H14F3N3O3/c19-18(20,21)15-3-1-2-12(6-15)10-27-11-13-4-5-16(22-7-13)24-9-14(8-23-24)17(25)26/h1-9H,10-11H2,(H,25,26)
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n/an/a 2.90E+3n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
Egl nine homolog 1


(Homo sapiens (Human))
BDBM50370785
PNG
(CHEMBL220743)
Show SMILES OC(=O)c1cnn(c1)-c1ccccn1
Show InChI InChI=1S/C9H7N3O2/c13-9(14)7-5-11-12(6-7)8-3-1-2-4-10-8/h1-6H,(H,13,14)
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n/an/a 1.20E+4n/an/an/an/an/an/a



Procter and Gamble Pharmaceuticals Inc

Curated by ChEMBL


Assay Description
Inhibition of human EGLN1


Bioorg Med Chem Lett 16: 5687-90 (2006)


Article DOI: 10.1016/j.bmcl.2006.08.017
BindingDB Entry DOI: 10.7270/Q25Q4WXS
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%