Compile Data Set for Download or QSAR
maximum 50k data
Found 33 Enz. Inhib. hit(s) with all data for entry = 2461
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20870(3-{2-[(thiophene-2-sulfonyl)methyl]-1,3-thiazol-4-...)
Affinity DataIC50:  2.10nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20851(7-(piperidin-1-ylcarbonyl)-3-[2-(pyridin-4-yl)-1,3...)
Affinity DataIC50:  2.70nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20856(4-amino-6-chloro-3-[2-(pyridin-4-yl)-1,3-thiazol-4...)
Affinity DataIC50:  3.80nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20850(7-[(4-methylpiperazin-1-yl)carbonyl]-3-[2-(pyridin...)
Affinity DataIC50:  4.40nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20848(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-7-(trifluoro...)
Affinity DataIC50:  6.30nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20849(N-[2-(dimethylamino)ethyl]-N-ethyl-2-oxo-3-[2-(pyr...)
Affinity DataIC50:  8.30nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20869(3-{2-[(pyridine-2-sulfonyl)methyl]-1,3-thiazol-4-y...)
Affinity DataIC50:  10nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20847(6-chloro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20855(4-amino-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2-...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20866(3-[2-(4-hydroxyphenyl)-1,3-thiazol-4-yl]-1,2-dihyd...)
Affinity DataIC50:  24nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20868(3-{2-[(benzenesulfonyl)methyl]-1,3-thiazol-4-yl}-1...)
Affinity DataIC50:  29nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20843(methyl 2-oxo-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20861(3-[2-(pyridin-3-yl)-1,3-thiazol-4-yl]-1,2-dihydroq...)
Affinity DataIC50:  50nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20842(3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2-dihydroq...)
Affinity DataIC50:  54nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20846(6-fluoro-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  110nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20858(4-amino-6-(4-methylpiperazin-1-yl)-3-[2-(pyridin-4...)
Affinity DataIC50:  120nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20874(3-{2-[(benzenesulfinyl)methyl]-1,3-thiazol-4-yl}-1...)
Affinity DataIC50:  120nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20852(4-hydroxy-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,...)
Affinity DataIC50:  160nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20865(3-[2-(4-aminophenyl)-1,3-thiazol-4-yl]-1,2-dihydro...)
Affinity DataIC50:  170nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20871(3-(2-{[(4-chlorobenzene)sulfonyl]methyl}-1,3-thiaz...)
Affinity DataIC50:  240nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20857(4-amino-6-(piperidin-1-yl)-3-[2-(pyridin-4-yl)-1,3...)
Affinity DataIC50:  250nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20872(3-[2-(methanesulfonylmethyl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  300nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20860(3-[2-(thiophen-3-yl)-1,3-thiazol-4-yl]-1,2-dihydro...)
Affinity DataIC50:  410nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20853(4-phenyl-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  470nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20845(N,N-diethyl-2-oxo-3-[2-(pyridin-4-yl)-1,3-thiazol-...)
Affinity DataIC50:  480nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20859(3-(2-phenyl-1,3-thiazol-4-yl)-1,2-dihydroquinolin-...)
Affinity DataIC50:  1.40E+3nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20854(4-methyl-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2...)
Affinity DataIC50:  2.80E+3nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20873(3-(2-{[(2-methylpropane-2-)sulfonyl]methyl}-1,3-th...)
Affinity DataIC50:  6.90E+3nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20864(3-[2-(4-chlorophenyl)-1,3-thiazol-4-yl]-1,2-dihydr...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20862(3-[2-(2-chlorophenyl)-1,3-thiazol-4-yl]-1,2-dihydr...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20867(3-[2-(4-methoxyphenyl)-1,3-thiazol-4-yl]-1,2-dihyd...)
Affinity DataIC50: >1.00E+4nMT: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20863(3-[2-(3-chlorophenyl)-1,3-thiazol-4-yl]-1,2-dihydr...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1 [99-307](Homo sapiens (Human))
Amgen

LigandPNGBDBM20844(2-oxo-3-[2-(pyridin-4-yl)-1,3-thiazol-4-yl]-1,2-di...)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:In vitro CDK assay using purified enzyme, was incubated at 25 °C with substrate, and test compounds in the presence of ATP/ [gamma-33P] ATP. 33P...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed