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Found 46 Enz. Inhib. hit(s) with all data for entry = 50021467
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50163251(2-(4-(4-hydroxyphenylthio)phenyl)-1H-benzo[d]imida...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225014(2-(4-((1-(4-chlorobenzyl)piperidin-3-yl)methoxy)ph...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM34064(2-arylbenzimidazole | CHEMBL179583)
Affinity DataIC50:  15nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225008(2-(4-(2-(1-benzoylpiperidin-4-yl)ethoxy)phenyl)-1H...)
Affinity DataIC50:  23nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225005(2-(4-((1s,4s)-4-(hydroxymethyl)cyclohexyloxy)pheny...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225011(2-(4-((1-benzylpiperidin-3-yl)methoxy)phenyl)-1H-b...)
Affinity DataIC50:  37nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224988(2-(4-((1-benzoylpiperidin-4-yl)methoxy)phenyl)-1H-...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224983(2-(4-(2-(1-benzylpiperidin-2-yl)ethoxy)phenyl)-1H-...)
Affinity DataIC50:  45nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225021(2-(4-(2-hydroxyethoxy)phenyl)-1H-benzo[d]imidazole...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225002(2-(4-(2-(1-benzoylpiperidin-2-yl)ethoxy)phenyl)-1H...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224997(2-(4-(2-(1-(4-chlorobenzyl)piperidin-2-yl)ethoxy)p...)
Affinity DataIC50:  53nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225006(2-(4-((1-(4-methoxybenzyl)piperidin-3-yl)methoxy)p...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224998(2-{4-[1-(4-methyl-benzyl)-piperidin-3-ylmethoxy]-p...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224993(2-(4-((1-(4-chlorobenzyl)piperidin-4-yl)methoxy)ph...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225012(2-(4-{2-[1-(4-methyl-benzyl)-piperidin-2-yl]-ethox...)
Affinity DataIC50:  61nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225018(2-(4-((1-(4-methoxybenzyl)piperidin-4-yl)methoxy)p...)
Affinity DataIC50:  67nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224986(2-{4-[1-(4-methyl-benzyl)-piperidin-4-ylmethoxy]-p...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225019(2-(4-((1-benzylpiperidin-4-yl)methoxy)phenyl)-1H-b...)
Affinity DataIC50:  70nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224981(2-(4-(3-hydroxycyclopentyloxy)phenyl)-1H-benzo[d]i...)
Affinity DataIC50:  72nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224980(2-(4-(3-hydroxypropoxy)phenyl)-1H-benzo[d]imidazol...)
Affinity DataIC50:  73nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224994(2-(4-(2-(1-(4-methoxybenzyl)piperidin-2-yl)ethoxy)...)
Affinity DataIC50:  74nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224990(2-(4-((1-acetylpiperidin-4-yl)methoxy)phenyl)-1H-b...)
Affinity DataIC50:  78nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224992(2-(4-(4-hydroxycyclohexyloxy)phenyl)-1H-benzo[d]im...)
Affinity DataIC50:  80nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224989(2-(4-(2-(1-(4-chlorobenzyl)piperidin-4-yl)ethoxy)p...)
Affinity DataIC50:  82nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224995(2-(4-(2-(1-acetylpiperidin-4-yl)ethoxy)phenyl)-1H-...)
Affinity DataIC50:  86nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224987(2-(4-(2-(1-benzylpiperidin-4-yl)ethoxy)phenyl)-1H-...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224996(2-(4-{2-[1-(4-methyl-benzyl)-piperidin-4-yl]-ethox...)
Affinity DataIC50:  90nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225020(2-(4-(2-(1-(4-methoxybenzyl)piperidin-4-yl)ethoxy)...)
Affinity DataIC50:  95nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224991(2-(4-(1-acetylpiperidin-3-yloxy)phenyl)-1H-benzo[d...)
Affinity DataIC50:  100nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225001(2-(4-(1-benzylpyrrolidin-3-yloxy)phenyl)-1H-benzo[...)
Affinity DataIC50:  109nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225007(2-(4-(3-(piperidin-1-yl)propoxy)phenyl)-1H-benzo[d...)
Affinity DataIC50:  110nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225016(2-(4-(2-(1-(3,4-dichlorobenzyl)piperidin-2-yl)etho...)
Affinity DataIC50:  114nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225015(2-(4-((1-acetylpiperidin-3-yl)methoxy)phenyl)-1H-b...)
Affinity DataIC50:  140nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224999(2-(4-(2-(1-(3,4-dichlorobenzyl)piperidin-4-yl)etho...)
Affinity DataIC50:  157nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224985(2-(4-(piperidin-3-ylmethoxy)phenyl)-1H-benzo[d]imi...)
Affinity DataIC50:  158nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225000(2-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-1H-benzo[d]...)
Affinity DataIC50:  174nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225022(2-(4-(3-(dimethylamino)propoxy)phenyl)-1H-benzo[d]...)
Affinity DataIC50:  176nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225013(2-(4-((1-(3,4-dichlorobenzyl)piperidin-4-yl)methox...)
Affinity DataIC50:  176nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224982(2-(4-((1-(3,4-dichlorobenzyl)piperidin-3-yl)methox...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224979(2-(4-(piperidin-3-yloxy)phenyl)-1H-benzo[d]imidazo...)
Affinity DataIC50:  180nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225004(2-(4-(piperidin-4-ylmethoxy)phenyl)-1H-benzo[d]imi...)
Affinity DataIC50:  231nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225003(2-(4-(1-methylpiperidin-4-yloxy)phenyl)-1H-benzo[d...)
Affinity DataIC50:  233nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224984(2-(4-(2-(1-acetylpiperidin-2-yl)ethoxy)phenyl)-1H-...)
Affinity DataIC50:  292nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225009(2-(4-((1r,4r)-4-(hydroxymethyl)cyclohexyloxy)pheny...)
Affinity DataIC50:  400nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225010(2-(4-(piperidin-4-yloxy)phenyl)-1H-benzo[d]imidazo...)
Affinity DataIC50:  710nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50225017(2-(4-(1-methylpyrrolidin-3-yloxy)phenyl)-1H-benzo[...)
Affinity DataIC50:  710nMAssay Description:Inhibition of human recombinant Chk2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed