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Found 66 Enz. Inhib. hit(s) with all data for entry = 50030725
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM35229(3-(10,11-dihydro-5H-dibenzo[b,f]azepin-5-yl)-N-met...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300525((1S,2R)-1-(3-fluorophenyl)-1-(3-methyl-1H-indol-1-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300513((1S,2R)-1-(7-fluoro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM30130(CHEMBL1201082 | CHEMBL41 | Fluoxetin | Fluoxetine ...)
Affinity DataIC50:  9.40nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300524((1S,2R)-1-(3-ethyl-1H-indol-1-yl)-1-(3-fluoropheny...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300533((1S,2R)-1-(3-fluorophenyl)-1-(1H-indol-1-yl)-3-(me...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300527((1S,2R)-1-(3-bromophenyl)-1-(1H-indol-1-yl)-3-(met...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300507((R)-3-(3-fluorophenyl)-3-(1H-indol-1-yl)-N-methylp...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300519((1S,2R)-1-(3-fluorophenyl)-1-(4-methyl-1H-indol-1-...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300536((1S,2R)-1-(3-chlorophenyl)-1-(1H-indol-1-yl)-3-(me...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300516((1S,2R)-1-(4-fluoro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300517((1S,2R)-1-(3-fluorophenyl)-1-(7-methyl-1H-indol-1-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300514((1S,2R)-1-(6-fluoro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300509((1S,2R)-1-(7-bromo-1H-indol-1-yl)-1-(3-fluoropheny...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300518((1S,2R)-1-(3-fluorophenyl)-1-(5-methyl-1H-indol-1-...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300520((1S,2R)-1-(7-chloro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  21nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300515((1S,2R)-1-(5-fluoro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50297365((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  28nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300508((R)-3-(1H-indol-1-yl)-N-methyl-3-phenylpropan-1-am...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300520((1S,2R)-1-(7-chloro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300518((1S,2R)-1-(3-fluorophenyl)-1-(5-methyl-1H-indol-1-...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300530((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-m-toly...)
Affinity DataIC50:  49nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300512((1S,2R)-1-(4-bromo-1H-indol-1-yl)-1-(3-fluoropheny...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300511((1S,2R)-1-(5-bromo-1H-indol-1-yl)-1-(3-fluoropheny...)
Affinity DataIC50:  52nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300526((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-(3-(tr...)
Affinity DataIC50:  54nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300522((1S,2R)-1-(5-chloro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300511((1S,2R)-1-(5-bromo-1H-indol-1-yl)-1-(3-fluoropheny...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300523((1S,2R)-1-(4-chloro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  64nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300515((1S,2R)-1-(5-fluoro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  78nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300522((1S,2R)-1-(5-chloro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300532((1S,2R)-1-(4-fluorophenyl)-1-(1H-indol-1-yl)-3-(me...)
Affinity DataIC50:  84nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300507((R)-3-(3-fluorophenyl)-3-(1H-indol-1-yl)-N-methylp...)
Affinity DataIC50:  91nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300534((1S,2R)-1-(2-fluorophenyl)-1-(1H-indol-1-yl)-3-(me...)
Affinity DataIC50:  92nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300521((1S,2R)-1-(6-chloro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  92nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300528((1S,2R)-1-(1H-indol-1-yl)-1-(3-methoxyphenyl)-3-(m...)
Affinity DataIC50:  111nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300509((1S,2R)-1-(7-bromo-1H-indol-1-yl)-1-(3-fluoropheny...)
Affinity DataIC50:  113nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300529((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-p-toly...)
Affinity DataIC50:  117nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300510((1S,2R)-1-(6-bromo-1H-indol-1-yl)-1-(3-fluoropheny...)
Affinity DataIC50:  124nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300513((1S,2R)-1-(7-fluoro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  175nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300512((1S,2R)-1-(4-bromo-1H-indol-1-yl)-1-(3-fluoropheny...)
Affinity DataIC50:  207nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300523((1S,2R)-1-(4-chloro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  221nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300519((1S,2R)-1-(3-fluorophenyl)-1-(4-methyl-1H-indol-1-...)
Affinity DataIC50:  228nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300531((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-o-toly...)
Affinity DataIC50:  232nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300531((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-o-toly...)
Affinity DataIC50:  266nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300537((1S,2R)-1-(2-chlorophenyl)-1-(1H-indol-1-yl)-3-(me...)
Affinity DataIC50:  304nMAssay Description:Inhibition of human NET expressed in MDCK-Net6 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300525((1S,2R)-1-(3-fluorophenyl)-1-(3-methyl-1H-indol-1-...)
Affinity DataIC50:  343nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50297365((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-phenyl...)
Affinity DataIC50:  358nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300530((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-m-toly...)
Affinity DataIC50:  377nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300529((1S,2R)-1-(1H-indol-1-yl)-3-(methylamino)-1-p-toly...)
Affinity DataIC50:  398nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50300516((1S,2R)-1-(4-fluoro-1H-indol-1-yl)-1-(3-fluorophen...)
Affinity DataIC50:  417nMAssay Description:Inhibition of human SERT expressed in JAR cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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