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Found 56 Enz. Inhib. hit(s) with all data for entry = 50031309
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50063544(1-(6-(methylthio)naphthalen-2-yl)propan-2-amine | ...)
Affinity DataKi:  450nMAssay Description:Inhibition of [3H]5-HT uptake at human SERT expressed in HEK293 cells after 10 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM25870(1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3...)
Affinity DataIC50:  3.17nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50063544(1-(6-(methylthio)naphthalen-2-yl)propan-2-amine | ...)
Affinity DataIC50:  74nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50063544(1-(6-(methylthio)naphthalen-2-yl)propan-2-amine | ...)
Affinity DataIC50:  74nMAssay Description:Inhibition of [3H]5-HT uptake at SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50024209((+/-)2-(4-Methoxy-phenyl)-1-methyl-ethylamine | (-...)
Affinity DataIC50:  173nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50029100(2-(4-Chloro-phenyl)-1-methyl-ethylamine | CHEMBL35...)
Affinity DataIC50:  182nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50029100(2-(4-Chloro-phenyl)-1-methyl-ethylamine | CHEMBL35...)
Affinity DataIC50:  207nMAssay Description:Inhibition of human noradrenaline transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50063544(1-(6-(methylthio)naphthalen-2-yl)propan-2-amine | ...)
Affinity DataIC50:  207nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50005247((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...)
Affinity DataIC50:  266nMAssay Description:Inhibition of human noradrenaline transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310850(2-N-Propargylamino-1-(4-methylthiophenyl)butane | ...)
Affinity DataIC50:  399nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50010588((RS)-3,4-(methylenedioxy)methamphetamine | 1-(1,3-...)
Affinity DataIC50:  405nMAssay Description:Inhibition of human noradrenaline transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310855(2-Amino-1-(4-methylthiophenyl)butane | 2-N-Methyla...)
Affinity DataIC50:  417nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50029100(2-(4-Chloro-phenyl)-1-methyl-ethylamine | CHEMBL35...)
Affinity DataIC50:  424nMAssay Description:Inhibition of human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50010588((RS)-3,4-(methylenedioxy)methamphetamine | 1-(1,3-...)
Affinity DataIC50:  425nMAssay Description:Inhibition of [3H]5-HT uptake at SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310866(2-N-Hydroxyamino-1-(4-methylthiophenyl)propane | C...)
Affinity DataIC50:  436nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310845(2-N-Methylamino-1-(4-methylthiophenyl)butane | CHE...)
Affinity DataIC50:  437nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310837(2-N-Ethylamino-1-(4-ethylthiophenyl)propane | CHEM...)
Affinity DataIC50:  478nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50005247((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...)
Affinity DataIC50:  478nMAssay Description:Inhibition of [3H]5-HT uptake at SERT in rat brain synaptosomeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310863(2-N,N-Dimethylamino-1-(4-methylthiophenyl)propane ...)
Affinity DataIC50:  520nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310859(2-N-Allylamino-1-(4-methylthiophenyl)propan | CHEM...)
Affinity DataIC50:  524nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310852(2-N-Hydroxyamino-1-(4-methylthiophenyl)butane | CH...)
Affinity DataIC50:  598nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310844(2-Amino-1-(4-methylthiophenyl)butane | 2-N-methyla...)
Affinity DataIC50:  611nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310847(2-N-(n-Propyl)amino-1-(4-methylthiophenyl)butane |...)
Affinity DataIC50:  621nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310838(2-N-Hydroxyamino-1-(4-ethylthiophenyl)propane | CH...)
Affinity DataIC50:  625nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310867(2-N-Methoxyamino-1-(4-methylthiophenyl)propane | C...)
Affinity DataIC50:  664nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310833(1-(4-Benzylsulfanyl-phenyl)-propylamine | CHEMBL10...)
Affinity DataIC50:  679nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310860(2-N-Propargylamino-1-(4-methylthiophenyl)propane |...)
Affinity DataIC50:  688nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310853(2-N-hydroxy-N-methylamino-1-(4-methylthiophenyl)bu...)
Affinity DataIC50:  695nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310858(2-N-Cyclopropylamino-1-(4-methylthiophenyl)propane...)
Affinity DataIC50:  702nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310836(2-N-Methylamino-1-(4-ethylthiophenyl)propane | CHE...)
Affinity DataIC50:  724nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310846(2-N-Ethylamino-1-(4-methylthiophenyl)butane | CHEM...)
Affinity DataIC50:  823nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310861(2-N-(2-Hydroxyethyl)amino-1-(4-methylthiophenyl)pr...)
Affinity DataIC50:  868nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310849(2-N-Cyclopropylamino-1-(4-methylthiophenyl)butane ...)
Affinity DataIC50:  872nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50005247((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...)
Affinity DataIC50:  890nMAssay Description:Inhibition of human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310856(2-N-Ethylamino-1-(4-methylthiophenyl)propane | CHE...)
Affinity DataIC50:  963nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50005247((+/-)2-Benzo[1,3]dioxol-5-yl-1-methyl-ethylamine |...)
Affinity DataIC50:  996nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50010588((RS)-3,4-(methylenedioxy)methamphetamine | 1-(1,3-...)
Affinity DataIC50:  1.06E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310840(2-Amino-1-(4-ethylthiophenyl)butane | CHEMBL107788...)
Affinity DataIC50:  1.29E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50164327(2-(4-Ethylsulfanyl-phenyl)-1-methyl-ethylamine | 2...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50010588((RS)-3,4-(methylenedioxy)methamphetamine | 1-(1,3-...)
Affinity DataIC50:  1.44E+3nMAssay Description:Inhibition of human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310842(2-N-Hydroxyamino-1-(4-ethylthiophenyl)butane | CHE...)
Affinity DataIC50:  1.45E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310839(2-(N-Methyl-N-hydroxy)amino-1-(4-ethylthiophenyl)p...)
Affinity DataIC50:  1.58E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310841(2-N-Ethylamino-1-(4-ethylthiophenyl)butane | CHEMB...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310857(2-N-(Isopropyl)amino-1-(4-methylthiophenyl)propane...)
Affinity DataIC50:  1.85E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310864(2-N-Hydroxy-N-methylamino-1-(4-methylthiophenyl)pr...)
Affinity DataIC50:  1.88E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310848(2-N-(Isopropyl)amino-1-(4-methylthiophenyl)butane ...)
Affinity DataIC50:  1.94E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310843(2-(N-Methyl-N-hydroxy)amino-1-(4-ethylthiophenyl)b...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50063544(1-(6-(methylthio)naphthalen-2-yl)propan-2-amine | ...)
Affinity DataIC50:  2.38E+3nMAssay Description:Inhibition of human noradrenaline transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50310851(2-N-(2-Methoxyethyl)amino-1-(4-methylthiophenyl)bu...)
Affinity DataIC50:  2.82E+3nMAssay Description:Inhibition of [3H]5-HT reuptake at rat SERT expressed in HEK293 cells after 2 mins by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
Trinity College

Curated by ChEMBL
LigandPNGBDBM50063544(1-(6-(methylthio)naphthalen-2-yl)propan-2-amine | ...)
Affinity DataIC50:  3.07E+3nMAssay Description:Inhibition of human dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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