Compile Data Set for Download or QSAR
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Found 34 Enz. Inhib. hit(s) with all data for entry = 50031336
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  3nMAssay Description:Inhibition of HER2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311465(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50:  4nMAssay Description:Inhibition of HER2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311462(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2...)
Affinity DataIC50:  7nMAssay Description:Inhibition of HER2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  15nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  19nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  124nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5445(CHEMBL554 | GW572016 | LAPATINIB DITOSYLATE | Lapa...)
Affinity DataIC50:  140nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311464(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50:  257nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  420nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311469(7-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2...)
Affinity DataIC50:  620nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311464(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50:  843nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311466(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-...)
Affinity DataIC50:  867nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311467(CHEMBL1080990 | ethyl 4-(3-chloro-4-(3-fluorobenzy...)
Affinity DataIC50:  934nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311462(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2...)
Affinity DataIC50:  960nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311463(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50:  980nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311462(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2...)
Affinity DataIC50:  1.16E+3nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311467(CHEMBL1080990 | ethyl 4-(3-chloro-4-(3-fluorobenzy...)
Affinity DataIC50:  1.21E+3nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311462(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2...)
Affinity DataIC50:  1.28E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  1.52E+3nMAssay Description:Inhibition of HER2 by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM5446(CHEMBL553 | ERLOTINIB HYDROCHLORIDE | Erlotinib | ...)
Affinity DataIC50:  1.89E+3nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311463(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50:  2.24E+3nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311468(7-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2...)
Affinity DataIC50:  3.84E+3nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311465(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311465(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor tyrosine-protein kinase erbB-2(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311466(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-...)
Affinity DataIC50: >5.00E+3nMAssay Description:Inhibition of HER2 in human SKBR3 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311469(7-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311464(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311463(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311466(4-(3-chloro-4-(pyridin-2-ylmethoxy)phenylamino)-3-...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311467(CHEMBL1080990 | ethyl 4-(3-chloro-4-(3-fluorobenzy...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311468(7-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2...)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of EGFR by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311465(4-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-3-me...)
Affinity DataIC50:  1.27E+4nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311469(7-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2...)
Affinity DataIC50:  1.51E+4nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))
Shanghai Hengrui Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50311468(7-(3-chloro-4-(3-fluorobenzyloxy)phenylamino)-N-(2...)
Affinity DataIC50:  7.72E+4nMAssay Description:Inhibition of EGFR in human A431 cells by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed