Compile Data Set for Download or QSAR
maximum 50k data
Found 52 Enz. Inhib. hit(s) with all data for entry = 50031349
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311713(CHEMBL1080279 | N-(2-(dimethylamino)ethyl)-N-(3-me...)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311728(3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)-N-(3-(...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311728(3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)-N-(3-(...)
Affinity DataIC50:  2nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311713(CHEMBL1080279 | N-(2-(dimethylamino)ethyl)-N-(3-me...)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311728(3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)-N-(3-(...)
Affinity DataIC50: <4nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311713(CHEMBL1080279 | N-(2-(dimethylamino)ethyl)-N-(3-me...)
Affinity DataIC50: <6nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311724(3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)-N-(2-(...)
Affinity DataIC50:  7nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311714(4-(2-(chroman-3-yl)benzo[d]thiazol-6-yl)pyrimidin-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311727(CHEMBL1081001 | N-(3-methoxybenzyl)-N-(2-methoxyet...)
Affinity DataIC50:  10nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311715(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[d]thiazo...)
Affinity DataIC50:  11nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311717(2-(chroman-3-yl)-4-fluoro-6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50:  14nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311725(CHEMBL1081193 | N-(3-methoxybenzyl)-6-(1H-pyrazol-...)
Affinity DataIC50:  18nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311724(3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)-N-(2-(...)
Affinity DataIC50:  20nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311731(2-(chroman-3-yl)-6-(3-methyl-1H-pyrazol-4-yl)benzo...)
Affinity DataIC50:  25nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311726(CHEMBL1081196 | N-ethyl-N-(3-methoxybenzyl)-6-(1H-...)
Affinity DataIC50:  26nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311718(2-(chroman-3-yl)-4-methoxy-6-(1H-pyrazol-4-yl)benz...)
Affinity DataIC50:  32nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311722(2-(6-fluorochroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[...)
Affinity DataIC50:  38nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311729(2-(chroman-3-yl)-6-(pyridin-4-yl)benzo[d]thiazole ...)
Affinity DataIC50:  42nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311721(2-(6-methoxychroman-3-yl)-6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50:  45nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311716(2-(chroman-3-yl)-5-fluoro-6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50:  47nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311720(CHEMBL1081182 | N1-(2-(chroman-3-yl)-6-(1H-pyrazol...)
Affinity DataIC50:  51nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311736(CHEMBL1080104 | N-benzyl-6-(1H-pyrazol-4-yl)benzo[...)
Affinity DataIC50:  53nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311723(CHEMBL1079919 | methyl 3-(6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50:  59nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311738(CHEMBL1081195 | N-(3-methoxybenzyl)-N-methyl-6-(1H...)
Affinity DataIC50:  59nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311719(2-(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[d]thi...)
Affinity DataIC50:  66nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311737(CHEMBL1081194 | N-(3-fluorobenzyl)-6-(1H-pyrazol-4...)
Affinity DataIC50:  72nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311735(2-(6-chlorochroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[...)
Affinity DataIC50:  75nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311734(2-(6-methylchroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[...)
Affinity DataIC50:  93nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311739(CHEMBL1080286 | N-cyclopropyl-N-(3-methoxybenzyl)-...)
Affinity DataIC50:  94nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 1(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311726(CHEMBL1081196 | N-ethyl-N-(3-methoxybenzyl)-6-(1H-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of ROCK1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311713(CHEMBL1080279 | N-(2-(dimethylamino)ethyl)-N-(3-me...)
Affinity DataIC50:  247nMAssay Description:Inhibition of MRCKalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311732(4-(2-(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[d]...)
Affinity DataIC50:  314nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311720(CHEMBL1081182 | N1-(2-(chroman-3-yl)-6-(1H-pyrazol...)
Affinity DataIC50:  365nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311719(2-(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[d]thi...)
Affinity DataIC50:  365nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311726(CHEMBL1081196 | N-ethyl-N-(3-methoxybenzyl)-6-(1H-...)
Affinity DataIC50:  455nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311733(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)-4-(2-(tetrahy...)
Affinity DataIC50:  500nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311727(CHEMBL1081001 | N-(3-methoxybenzyl)-N-(2-methoxyet...)
Affinity DataIC50:  871nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311730(2-(chroman-3-yl)-6-(2-methylpyridin-4-yl)benzo[d]t...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of ROCK2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311718(2-(chroman-3-yl)-4-methoxy-6-(1H-pyrazol-4-yl)benz...)
Affinity DataIC50:  1.24E+3nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311723(CHEMBL1079919 | methyl 3-(6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50:  1.49E+3nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311722(2-(6-fluorochroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[...)
Affinity DataIC50:  1.49E+3nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311714(4-(2-(chroman-3-yl)benzo[d]thiazol-6-yl)pyrimidin-...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311715(2-(chroman-3-yl)-6-(1H-pyrazol-4-yl)benzo[d]thiazo...)
Affinity DataIC50:  1.55E+3nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311725(CHEMBL1081193 | N-(3-methoxybenzyl)-6-(1H-pyrazol-...)
Affinity DataIC50: >2.70E+3nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311716(2-(chroman-3-yl)-5-fluoro-6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50: >2.70E+3nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311721(2-(6-methoxychroman-3-yl)-6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50: >2.70E+3nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRho-associated protein kinase 2(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311717(2-(chroman-3-yl)-4-fluoro-6-(1H-pyrazol-4-yl)benzo...)
Affinity DataIC50: >2.70E+3nMAssay Description:Inhibition of ROCK2 assessed as myosin light chain phosphorylation by cell-based assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 10(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311728(3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)-N-(3-(...)
Affinity DataIC50:  5.46E+3nMAssay Description:Inhibition of JNK3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311726(CHEMBL1081196 | N-ethyl-N-(3-methoxybenzyl)-6-(1H-...)
Affinity DataIC50:  7.86E+3nMAssay Description:Inhibition of MRCKalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase MRCK alpha(Homo sapiens (Human))
Translational Research Institute And Department Of Molecular Therapeutics

Curated by ChEMBL
LigandPNGBDBM50311728(3-(6-(1H-pyrazol-4-yl)benzo[d]thiazol-2-yl)-N-(3-(...)
Affinity DataIC50:  9.55E+3nMAssay Description:Inhibition of MRCKalphaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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