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Found 21 Enz. Inhib. hit(s) with all data for entry = 50033166
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Affinity DataKi:  0.200nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Affinity DataKi:  0.260nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340726(5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...)
Affinity DataKi:  1.20nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340730(5,7-Dimethyl-2-(ethylthio)-3-phenylsulfonyl-pyrazo...)
Affinity DataKi:  1.91nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340726(5,7-dimethyl-2-(methylthio)-3-(phenylsulfonyl)pyra...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340731(CHEMBL1762569 | N,N,5,7-Tetramethyl-3-(phenylsulfo...)
Affinity DataKi:  14.5nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340728(2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]...)
Affinity DataKi:  22.2nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340727(2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyr...)
Affinity DataKi:  68.4nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340727(2,5,7-Triimethyl-phenylsulfonyl-pyrazolo[1,5-a]pyr...)
Affinity DataKi:  88.8nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340729(5,7-Dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrim...)
Affinity DataKi:  237nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT6 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340728(2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a]...)
Affinity DataKi:  283nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340732(CHEMBL1762572 | N-[5,7-Dimethyl-3-(phenylsulfonyl)...)
Affinity DataKi:  489nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340729(5,7-Dimethyl-3-phenylsulfonyl-pyrazolo[1,5-a]pyrim...)
Affinity DataKi:  561nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340733(CHEMBL1762573 | N'-[5,7-Dimethyl-3-(phenylsulfonyl...)
Affinity DataKi:  764nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Affinity DataKi:  1.04E+3nMAssay Description:Antagonist activity at human 5HT2B receptor expressed in HEK293 cells assessed as inhibition of alpha-Me-serotonin-induced intracellular calcium mobi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340734(5,7-Dimethyl-3-(phenylsulfonyl)-2-piperazin-1-ylpy...)
Affinity DataKi:  1.38E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340735((2-{[5,7-Dimethyl-3-(phenylsulfonyl)pyrazolo[1,5-a...)
Affinity DataKi:  2.20E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340736(CHEMBL1762576 | N'-[5,7-Dimethyl-3-(phenylsulfonyl...)
Affinity DataKi:  2.60E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 6(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340737(5,7-Dimethyl-2-(methylsulfinyl)-3-(phenylsulfonyl)...)
Affinity DataKi:  2.96E+3nMAssay Description:Antagonist activity at human recombinant 5HT6 receptor expressed in HEK293 cells assessed as inhibition of serotonin-induced cAMP production after 2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2B(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Affinity DataIC50:  5.13E+3nMAssay Description:Displacement of [3H]lysergic acid diethylamide from human recombinant 5HT2B receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
Chemical Diversity Research Institute

Curated by ChEMBL
LigandPNGBDBM50340725(CHEMBL1668584 | N,5,7-trimethyl-3-(phenylsulfonyl)...)
Affinity DataIC50: >3.00E+4nMAssay Description:Antagonist activity at human ERG by patch clamp methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed