Compile Data Set for Download or QSAR
maximum 50k data
Found 45 Enz. Inhib. hit(s) with all data for entry = 50033192
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341181((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-tert-...)
Affinity DataIC50:  55nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341175(CHEMBL1760860 | Methyl-carbamic acid 2-bromo-4-[(3...)
Affinity DataIC50:  60nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341176((4S)-4-(2-hydroxy-5-{[(3S,4S,5R)-4-hydroxy-1,1-dio...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341171((3S,4S,5R)-3-(3-Butyl-4-hydroxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  150nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341172((3S,4S,5R)-3-(4-Hydroxy-3-propyl-benzyl)-5-(3-isop...)
Affinity DataIC50:  190nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341174((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  300nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341175(CHEMBL1760860 | Methyl-carbamic acid 2-bromo-4-[(3...)
Affinity DataIC50:  370nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341173((3S,4S,5R)-3-(3-Ethyl-4-hydroxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  370nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341181((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-tert-...)
Affinity DataIC50:  420nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341181((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-tert-...)
Affinity DataIC50:  550nMAssay Description:Inhibition of human BACE-1-mediated amyloid beta 40 release in APP-transfected human CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341182((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  670nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341163((+/-)-(3S,4S,5R)-3-(3-Bromo-benzyl)-5-(3-isopropyl...)
Affinity DataIC50:  760nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341165((+/-)-(3R,4S,5S)-3-(3-Isopropyl-benzylami no)-1,1-...)
Affinity DataIC50:  900nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341184((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-cyclo...)
Affinity DataIC50:  950nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341170((3S,4S,5R)-3-[4-Hydroxy-3-(2-hydroxy-ethyl)-benzyl...)
Affinity DataIC50:  990nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341162((+/-)-(3S,4S,5R)-3-Benzyl-5-(3-isopropyl-benzylami...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341165((+/-)-(3R,4S,5S)-3-(3-Isopropyl-benzylami no)-1,1-...)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341174((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341169((3S,4S,5R)-3-(4-Hydroxy-3-hydroxymethyl-benzyl)-5-...)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341182((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341174((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human BACE-1-mediated amyloid beta 40 release in APP-transfected human CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341170((3S,4S,5R)-3-[4-Hydroxy-3-(2-hydroxy-ethyl)-benzyl...)
Affinity DataIC50:  1.70E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341167((+/-)-(3S,4S,5R)-3-(4-Hydroxy-benzyl)-5-(3-isoprop...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341172((3S,4S,5R)-3-(4-Hydroxy-3-propyl-benzyl)-5-(3-isop...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341171((3S,4S,5R)-3-(3-Butyl-4-hydroxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341162((+/-)-(3S,4S,5R)-3-Benzyl-5-(3-isopropyl-benzylami...)
Affinity DataIC50:  1.90E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341164((+/-)-(3R,4S,5S)-3-(3-Isopropyl-benzylamino)-1,1-d...)
Affinity DataIC50:  2.00E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341169((3S,4S,5R)-3-(4-Hydroxy-3-hydroxymethyl-benzyl)-5-...)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341163((+/-)-(3S,4S,5R)-3-(3-Bromo-benzyl)-5-(3-isopropyl...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341164((+/-)-(3R,4S,5S)-3-(3-Isopropyl-benzylamino)-1,1-d...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341166((3S,4S,5R)-3-(3-Bromo-4-methoxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341173((3S,4S,5R)-3-(3-Ethyl-4-hydroxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341166((3S,4S,5R)-3-(3-Bromo-4-methoxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341177(CHEMBL1760861 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  3.20E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341185((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3,5-dic...)
Affinity DataIC50:  4.20E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341180((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-[(4-isop...)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341177(CHEMBL1760861 | N-((2S,3R)-1-(3,5-difluorophenyl)-...)
Affinity DataIC50:  4.70E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341167((+/-)-(3S,4S,5R)-3-(4-Hydroxy-benzyl)-5-(3-isoprop...)
Affinity DataIC50:  5.40E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341168((+/-)-(3S,4S,5R)-3-[4-Hydroxy-3-(3-methyl-benzyl)-...)
Affinity DataIC50:  6.20E+3nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341176((4S)-4-(2-hydroxy-5-{[(3S,4S,5R)-4-hydroxy-1,1-dio...)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341168((+/-)-(3S,4S,5R)-3-[4-Hydroxy-3-(3-methyl-benzyl)-...)
Affinity DataIC50:  7.10E+3nMAssay Description:Inhibition of human cathepsin DMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341182((3S,4S,5R)-3-(3-Bromo-4-hydroxy-benzyl)-5-(3-isopr...)
Affinity DataIC50:  8.50E+3nMAssay Description:Inhibition of human BACE-1-mediated amyloid beta 40 release in APP-transfected human CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341183((3R,4S,5S)-3-(3-bromo-4-hydroxybenzyl)-5-(3-isopro...)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341179((3R,4S,5S)-3-Benzylamino-5-(3-bromo-4-hydroxy-benz...)
Affinity DataIC50:  6.60E+4nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50341178((3R,4S,5S)-3-Amino-5-(3-bromo-4-hydroxy-benzyl)-1,...)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human BACE-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed