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Found 51 Enz. Inhib. hit(s) with all data for entry = 50049201
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236320(CHEMBL4091106)
Affinity DataIC50:  2.60nMAssay Description:Inhibitory concentration was evaluated against Farnesyltransferase in the farnesylation of H-ras proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236287(CHEMBL4071967)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236288(CHEMBL4098945)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236325(CHEMBL4099755)
Affinity DataIC50:  3.90nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236291(CHEMBL4060570)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236289(CHEMBL4082453)
Affinity DataIC50:  4.20nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236319(CHEMBL4101407)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236324(CHEMBL4080801)
Affinity DataIC50:  5.30nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236323(CHEMBL4070144)
Affinity DataIC50:  6.10nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236286(CHEMBL4079985)
Affinity DataIC50:  6.40nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM66082((2S)-2-[[4-[(2,4-diaminopteridin-6-yl)methyl-methy...)
Affinity DataIC50:  7.90nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236285(CHEMBL4098009)
Affinity DataIC50:  9nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236284(CHEMBL4069255)
Affinity DataIC50:  9.20nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236290(CHEMBL4083419)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236283(CHEMBL4074887)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM82109(6,8,10-Traiazaspiro[4.5]deca-6,8-diene-7,9-diamine...)
Affinity DataIC50:  20nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236282(CHEMBL4104895)
Affinity DataIC50:  36nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236322(CHEMBL4080662)
Affinity DataIC50:  53nMAssay Description:Inhibition of recombinant human DHFR assessed as reduction in conversion of DHF to THF measured every 30 secs for 6 mins by UV-Vis spectrophotometric...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236321(CHEMBL4097389)
Affinity DataIC50:  59nMAssay Description:Binding affinity towards human muscarinic M3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236287(CHEMBL4071967)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibitory concentration was evaluated against Farnesyltransferase in the farnesylation of H-ras proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236319(CHEMBL4101407)
Affinity DataIC50:  3.80E+3nMAssay Description:Inhibitory concentration was evaluated against Farnesyltransferase in the farnesylation of H-ras proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236321(CHEMBL4097389)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of high affinity uptake of [3H]dopamine into striatal nerve endings (synaptosomes)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236287(CHEMBL4071967)
Affinity DataIC50:  4.10E+3nMAssay Description:Binding affinity towards dopamine transporter using [3H]- mazindol as radioligand in rat striatal membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236323(CHEMBL4070144)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 60 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236290(CHEMBL4083419)
Affinity DataIC50:  4.60E+3nMAssay Description:Inhibitory concentration was evaluated against Farnesyltransferase in the farnesylation of H-ras proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236321(CHEMBL4097389)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236320(CHEMBL4091106)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 60 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236319(CHEMBL4101407)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 30 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236289(CHEMBL4082453)
Affinity DataIC50:  6.70E+3nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 60 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236282(CHEMBL4104895)
Affinity DataIC50:  6.90E+3nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 60 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236323(CHEMBL4070144)
Affinity DataIC50:  7.50E+3nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 30 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236290(CHEMBL4083419)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 30 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236285(CHEMBL4098009)
Affinity DataIC50:  8.20E+3nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236320(CHEMBL4091106)
Affinity DataIC50:  9.20E+3nMAssay Description:Affinity towards human M1 receptor expressed in CHO cells using [3H]QNB as radioligandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236282(CHEMBL4104895)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236285(CHEMBL4098009)
Affinity DataIC50:  1.08E+4nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 30 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236289(CHEMBL4082453)
Affinity DataIC50:  1.12E+4nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 30 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236283(CHEMBL4074887)
Affinity DataIC50:  2.04E+4nMAssay Description:In vitro functional agonism against M1 muscarinic receptor (PI)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236322(CHEMBL4080662)
Affinity DataIC50:  2.11E+4nMAssay Description:Binding affinity towards human muscarinic M2 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236291(CHEMBL4060570)
Affinity DataIC50:  2.11E+4nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236286(CHEMBL4079985)
Affinity DataIC50:  2.57E+4nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  2.67E+4nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 60 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236288(CHEMBL4098945)
Affinity DataIC50:  2.70E+4nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236322(CHEMBL4080662)
Affinity DataIC50:  2.98E+4nMAssay Description:Inhibitory concentration against Farnesyltransferase for Farnesylation of H-ras protein InNIH 3T3 cells transformed with activated H-rasMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236291(CHEMBL4060570)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of high affinity uptake of [3H]dopamine into striatal nerve endings (synaptosomes)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236284(CHEMBL4069255)
Affinity DataIC50:  3.24E+4nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 60 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236286(CHEMBL4079985)
Affinity DataIC50:  3.59E+4nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 30 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236283(CHEMBL4074887)
Affinity DataIC50:  4.33E+4nMAssay Description:In vitro inhibitory activity against Geranylgeranyl transferase in the geranylgeranylation of H-ras-CAIL proteinMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM50236288(CHEMBL4098945)
Affinity DataIC50:  4.45E+4nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 30 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Rattus norvegicus)
National University Of Singapore

Curated by ChEMBL
LigandPNGBDBM29143(CHEMBL7976 | Chalcone 1 | Chalcone, 13 | cid_63776...)
Affinity DataIC50:  4.64E+4nMAssay Description:Inhibition of recombinant rat liver thioredoxin reductase after 30 mins by DTNB reduction assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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