Found 58 Enz. Inhib. hit(s) with all data for entry = 50000288 
Affinity DataIC50: 3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of mammalian ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of mammalian ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 13nMAssay Description:Inhibition of mammalian ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of mammalian ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of Purine nucleoside Phosphorylase from calf spleen at 50 mM PO4More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of full length His6-tagged BRAF (unknown origin) expressed in baculovirus expression system assessed as reduction in MEK phosphorylation b...More data for this Ligand-Target Pair
Affinity DataIC50: 20nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Cross inhibitory potency of compound on Saccharomyces cerevisiae R2 C-terminal peptide on Saccharomyces cerevisiae ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of NEP 24.11 from rat kidneyMore data for this Ligand-Target Pair
Affinity DataIC50: 32nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 50nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of mammalian ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 63nMAssay Description:Inhibition of human Myc-tagged TNNI3K autophosphorylation expressed in HEKMSR2 cells after 30 mins by DELFIAMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of Purine nucleoside Phosphorylase from calf spleen at 50 mM PO4More data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of mammalian ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
3D Structure (crystal)
Affinity DataIC50: 79nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of mammalian ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Binding affinity against purine binding site of Purine nucleoside PhosphorylaseMore data for this Ligand-Target Pair
Affinity DataIC50: 79nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 80nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 130nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of full length His6-tagged BRAF (unknown origin) expressed in baculovirus expression system assessed as reduction in MEK phosphorylation b...More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of Purine nucleoside Phosphorylase from calf spleen at 50 mM PO4More data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of mammalian ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 250nMAssay Description:Inhibition of full length His6-tagged BRAF (unknown origin) expressed in baculovirus expression system assessed as reduction in MEK phosphorylation b...More data for this Ligand-Target Pair
Affinity DataIC50: 320nMAssay Description:Inhibition of Purine nucleoside Phosphorylase from calf spleen at 1 mM PO4More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of mammalian ribonucleotide reductaseMore data for this Ligand-Target Pair
Affinity DataIC50: 400nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of human Myc-tagged TNNI3K autophosphorylation expressed in HEKMSR2 cells after 30 mins by DELFIAMore data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of full length His6-tagged BRAF (unknown origin) expressed in baculovirus expression system assessed as reduction in MEK phosphorylation b...More data for this Ligand-Target Pair
Affinity DataIC50: 500nMAssay Description:Inhibition of Purine nucleoside Phosphorylase from calf spleen at 50 mM PO4More data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Inhibitory activity of compound against mammalian ribonucleotide reductase; Range is 8-20More data for this Ligand-Target Pair
Affinity DataIC50: 630nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of 5-({[2-({[3-({4-[(5-hydroxy-2-methylphenyl)amino]-2-pyrimidinyl}amino)phenyl]carbonyl}amino)-ethyl]amino}carbonyl)-2-(6-hydroxy-3-oxo-3...More data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair
