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PubMed code 8360871

Compile data set for download or QSAR
Found 86 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230906
PNG
(CHEMBL308261)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(Cl)ccc1Cl
Show InChI InChI=1S/C25H21Cl2N7O2/c1-2-5-21-28-24(34-19(26)12-13-20(34)27)22(25(35)36)33(21)14-15-8-10-16(11-9-15)17-6-3-4-7-18(17)23-29-31-32-30-23/h3-4,6-13H,2,5,14H2,1H3,(H,35,36)(H,29,30,31,32)
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n/an/a 0.410n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230919
PNG
(CHEMBL307844 | CI-996)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O3/c1-2-6-21-31-25(36-14-5-9-20(36)23(38)27(28,29)30)22(26(39)40)37(21)15-16-10-12-17(13-11-16)18-7-3-4-8-19(18)24-32-34-35-33-24/h3-5,7-14H,2,6,15H2,1H3,(H,39,40)(H,32,33,34,35)
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n/an/a 0.580n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230891
PNG
(CHEMBL76166)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C=O
Show InChI InChI=1S/C26H23N7O3/c1-2-6-22-27-25(32-14-5-7-19(32)16-34)23(26(35)36)33(22)15-17-10-12-18(13-11-17)20-8-3-4-9-21(20)24-28-30-31-29-24/h3-5,7-14,16H,2,6,15H2,1H3,(H,35,36)(H,28,29,30,31)
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n/an/a 0.800n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230883
PNG
(CHEMBL309089)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C27H27N7O2/c1-4-7-23-28-26(34-17(2)10-11-18(34)3)24(27(35)36)33(23)16-19-12-14-20(15-13-19)21-8-5-6-9-22(21)25-29-31-32-30-25/h5-6,8-15H,4,7,16H2,1-3H3,(H,35,36)(H,29,30,31,32)
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n/an/a 0.820n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230915
PNG
(CHEMBL76169)
Show SMILES CCCc1ccc(C)n1-c1nc(CCC)n(Cc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c1C(O)=O
Show InChI InChI=1S/C29H31N7O2/c1-4-8-22-17-12-19(3)36(22)28-26(29(37)38)35(25(30-28)9-5-2)18-20-13-15-21(16-14-20)23-10-6-7-11-24(23)27-31-33-34-32-27/h6-7,10-17H,4-5,8-9,18H2,1-3H3,(H,37,38)(H,31,32,33,34)
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n/an/a 0.900n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230887
PNG
(CHEMBL306259)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(O)C(F)(F)F
Show InChI InChI=1S/C27H24F3N7O3/c1-2-6-21-31-25(36-14-5-9-20(36)23(38)27(28,29)30)22(26(39)40)37(21)15-16-10-12-17(13-11-16)18-7-3-4-8-19(18)24-32-34-35-33-24/h3-5,7-14,23,38H,2,6,15H2,1H3,(H,39,40)(H,32,33,34,35)
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n/an/a 1n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230912
PNG
(CHEMBL72922)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C25H23N7O2/c1-2-7-21-26-24(31-14-5-6-15-31)22(25(33)34)32(21)16-17-10-12-18(13-11-17)19-8-3-4-9-20(19)23-27-29-30-28-23/h3-6,8-15H,2,7,16H2,1H3,(H,33,34)(H,27,28,29,30)
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n/an/a 1.20n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230886
PNG
(CHEMBL307455)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1ccc(C(=O)OC)c1C
Show InChI InChI=1S/C28H27N7O4/c1-4-7-23-29-26(34-15-14-20(17(34)2)28(38)39-3)24(27(36)37)35(23)16-18-10-12-19(13-11-18)21-8-5-6-9-22(21)25-30-32-33-31-25/h5-6,8-15H,4,7,16H2,1-3H3,(H,36,37)(H,30,31,32,33)
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n/an/a 1.40n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230910
PNG
(CHEMBL306066)
Show SMILES CCCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C26H25N7O2/c1-2-3-10-22-27-25(32-15-6-7-16-32)23(26(34)35)33(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)24-28-30-31-29-24/h4-9,11-16H,2-3,10,17H2,1H3,(H,34,35)(H,28,29,30,31)
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n/an/a 1.60n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230882
PNG
(CARBOXYLIC ACID METABOLITE | CHEBI:74125 | E-3174)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)
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n/an/a 1.60n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Tested for inhibitory concentration against AT1 receptor binding affinity in rat liver


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230882
PNG
(CARBOXYLIC ACID METABOLITE | CHEBI:74125 | E-3174)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)
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n/an/a 1.60n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230882
PNG
(CARBOXYLIC ACID METABOLITE | CHEBI:74125 | E-3174)
Show SMILES CCCCc1nc(Cl)c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Show InChI InChI=1S/C22H21ClN6O2/c1-2-3-8-18-24-20(23)19(22(30)31)29(18)13-14-9-11-15(12-10-14)16-6-4-5-7-17(16)21-25-27-28-26-21/h4-7,9-12H,2-3,8,13H2,1H3,(H,30,31)(H,25,26,27,28)
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n/an/a 1.80n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230877
PNG
(CHEMBL70371)
Show SMILES CCCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)C(F)(F)F
Show InChI InChI=1S/C28H24F3N7O3/c1-2-3-10-22-32-26(37-15-6-9-21(37)24(39)28(29,30)31)23(27(40)41)38(22)16-17-11-13-18(14-12-17)19-7-4-5-8-20(19)25-33-35-36-34-25/h4-9,11-15H,2-3,10,16H2,1H3,(H,40,41)(H,33,34,35,36)
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n/an/a 2.40n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230883
PNG
(CHEMBL309089)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C27H27N7O2/c1-4-7-23-28-26(34-17(2)10-11-18(34)3)24(27(35)36)33(23)16-19-12-14-20(15-13-19)21-8-5-6-9-22(21)25-29-31-32-30-25/h5-6,8-15H,4,7,16H2,1-3H3,(H,35,36)(H,29,30,31,32)
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n/an/a 2.40n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230900
PNG
(CHEMBL73433)
Show SMILES CCCc1nc(c(\C=C(/C)C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C28H27N7O2/c1-3-8-25-29-27(34-15-6-7-16-34)24(17-19(2)28(36)37)35(25)18-20-11-13-21(14-12-20)22-9-4-5-10-23(22)26-30-32-33-31-26/h4-7,9-17H,3,8,18H2,1-2H3,(H,36,37)(H,30,31,32,33)/b19-17+
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n/an/a 2.5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230891
PNG
(CHEMBL76166)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C=O
Show InChI InChI=1S/C26H23N7O3/c1-2-6-22-27-25(32-14-5-7-19(32)16-34)23(26(35)36)33(22)15-17-10-12-18(13-11-17)20-8-3-4-9-21(20)24-28-30-31-29-24/h3-5,7-14,16H,2,6,15H2,1H3,(H,35,36)(H,28,29,30,31)
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n/an/a 2.60n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230902
PNG
(CHEMBL75518)
Show SMILES CCCc1nc(c(\C=C(/C)C(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C30H31N7O2/c1-4-10-27-31-29(36-17-8-9-18-36)26(19-21(3)30(38)39-5-2)37(27)20-22-13-15-23(16-14-22)24-11-6-7-12-25(24)28-32-34-35-33-28/h6-9,11-19H,4-5,10,20H2,1-3H3,(H,32,33,34,35)/b21-19+
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n/an/a 2.80n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230893
PNG
(CHEMBL308031)
Show SMILES Cc1ccc(C)n1-c1nc(C2CC2)n(Cc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c1C(O)=O
Show InChI InChI=1S/C27H25N7O2/c1-16-7-8-17(2)34(16)26-23(27(35)36)33(25(28-26)20-13-14-20)15-18-9-11-19(12-10-18)21-5-3-4-6-22(21)24-29-31-32-30-24/h3-12,20H,13-15H2,1-2H3,(H,35,36)(H,29,30,31,32)
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n/an/a 2.80n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230887
PNG
(CHEMBL306259)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(O)C(F)(F)F
Show InChI InChI=1S/C27H24F3N7O3/c1-2-6-21-31-25(36-14-5-9-20(36)23(38)27(28,29)30)22(26(39)40)37(21)15-16-10-12-17(13-11-16)18-7-3-4-8-19(18)24-32-34-35-33-24/h3-5,7-14,23,38H,2,6,15H2,1H3,(H,39,40)(H,32,33,34,35)
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n/an/a 2.90n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230881
PNG
(CHEMBL308779)
Show SMILES CCCc1nc(c(\C=C\C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C29H29N7O2/c1-4-7-26-30-29(36-19(2)10-11-20(36)3)25(16-17-27(37)38)35(26)18-21-12-14-22(15-13-21)23-8-5-6-9-24(23)28-31-33-34-32-28/h5-6,8-17H,4,7,18H2,1-3H3,(H,37,38)(H,31,32,33,34)/b17-16+
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n/an/a 3.30n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230906
PNG
(CHEMBL308261)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(Cl)ccc1Cl
Show InChI InChI=1S/C25H21Cl2N7O2/c1-2-5-21-28-24(34-19(26)12-13-20(34)27)22(25(35)36)33(21)14-15-8-10-16(11-9-15)17-6-3-4-7-18(17)23-29-31-32-30-23/h3-4,6-13H,2,5,14H2,1H3,(H,35,36)(H,29,30,31,32)
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n/an/a 3.30n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230908
PNG
(CHEMBL443269 | DuP-532)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)C(F)(F)C(F)(F)F
Show InChI InChI=1S/C23H19F5N6O2/c1-2-5-17-29-19(22(24,25)23(26,27)28)18(21(35)36)34(17)12-13-8-10-14(11-9-13)15-6-3-4-7-16(15)20-30-32-33-31-20/h3-4,6-11H,2,5,12H2,1H3,(H,35,36)(H,30,31,32,33)
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n/an/a 3.40n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Tested for inhibitory concentration against AT1 receptor binding affinity in rat liver


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230897
PNG
(CHEMBL275652)
Show SMILES CCCCc1nc(c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)C(F)(F)F
Show InChI InChI=1S/C29H26F3N7O3/c1-3-4-11-23-33-27(38-16-7-10-22(38)25(40)29(30,31)32)24(28(41)42-2)39(23)17-18-12-14-19(15-13-18)20-8-5-6-9-21(20)26-34-36-37-35-26/h5-10,12-16H,3-4,11,17H2,1-2H3,(H,34,35,36,37)
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n/an/a 3.60n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230909
PNG
(CHEMBL306852)
Show SMILES CCCc1nc(c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)C(F)(F)F
Show InChI InChI=1S/C28H24F3N7O3/c1-3-7-22-32-26(37-15-6-10-21(37)24(39)28(29,30)31)23(27(40)41-2)38(22)16-17-11-13-18(14-12-17)19-8-4-5-9-20(19)25-33-35-36-34-25/h4-6,8-15H,3,7,16H2,1-2H3,(H,33,34,35,36)
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n/an/a 3.60n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230919
PNG
(CHEMBL307844 | CI-996)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)C(F)(F)F
Show InChI InChI=1S/C27H22F3N7O3/c1-2-6-21-31-25(36-14-5-9-20(36)23(38)27(28,29)30)22(26(39)40)37(21)15-16-10-12-17(13-11-16)18-7-3-4-8-19(18)24-32-34-35-33-24/h3-5,7-14H,2,6,15H2,1H3,(H,39,40)(H,32,33,34,35)
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n/an/a 3.80n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230914
PNG
(CHEMBL431390)
Show SMILES CCCc1nc(c(C(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(Cl)ccc1Cl
Show InChI InChI=1S/C27H25Cl2N7O2/c1-3-7-23-30-26(36-21(28)14-15-22(36)29)24(27(37)38-4-2)35(23)16-17-10-12-18(13-11-17)19-8-5-6-9-20(19)25-31-33-34-32-25/h5-6,8-15H,3-4,7,16H2,1-2H3,(H,31,32,33,34)
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n/an/a 3.90n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230888
PNG
(CHEMBL306612)
Show SMILES CCCc1nc(c(\C=C\C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C27H25N7O2/c1-2-7-24-28-27(33-16-5-6-17-33)23(14-15-25(35)36)34(24)18-19-10-12-20(13-11-19)21-8-3-4-9-22(21)26-29-31-32-30-26/h3-6,8-17H,2,7,18H2,1H3,(H,35,36)(H,29,30,31,32)/b15-14+
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n/an/a 4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230877
PNG
(CHEMBL70371)
Show SMILES CCCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)C(F)(F)F
Show InChI InChI=1S/C28H24F3N7O3/c1-2-3-10-22-32-26(37-15-6-9-21(37)24(39)28(29,30)31)23(27(40)41)38(22)16-17-11-13-18(14-12-17)19-7-4-5-8-20(19)25-33-35-36-34-25/h4-9,11-15H,2-3,10,16H2,1H3,(H,40,41)(H,33,34,35,36)
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n/an/a 4n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230915
PNG
(CHEMBL76169)
Show SMILES CCCc1ccc(C)n1-c1nc(CCC)n(Cc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c1C(O)=O
Show InChI InChI=1S/C29H31N7O2/c1-4-8-22-17-12-19(3)36(22)28-26(29(37)38)35(25(30-28)9-5-2)18-20-13-15-21(16-14-20)23-10-6-7-11-24(23)27-31-33-34-32-27/h6-7,10-17H,4-5,8-9,18H2,1-3H3,(H,37,38)(H,31,32,33,34)
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n/an/a 4.5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230893
PNG
(CHEMBL308031)
Show SMILES Cc1ccc(C)n1-c1nc(C2CC2)n(Cc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c1C(O)=O
Show InChI InChI=1S/C27H25N7O2/c1-16-7-8-17(2)34(16)26-23(27(35)36)33(25(28-26)20-13-14-20)15-18-9-11-19(12-10-18)21-5-3-4-6-22(21)24-29-31-32-30-24/h3-12,20H,13-15H2,1-2H3,(H,35,36)(H,29,30,31,32)
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n/an/a 4.80n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 5n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Tested for inhibitory concentration against AT1 receptor binding affinity in rat liver


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230912
PNG
(CHEMBL72922)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C25H23N7O2/c1-2-7-21-26-24(31-14-5-6-15-31)22(25(33)34)32(21)16-17-10-12-18(13-11-17)19-8-3-4-9-20(19)23-27-29-30-28-23/h3-6,8-15H,2,7,16H2,1H3,(H,33,34)(H,27,28,29,30)
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n/an/a 5.40n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230899
PNG
(CHEMBL75935)
Show SMILES CCCc1nc(cn1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C24H23N7/c1-2-7-22-25-23(30-14-5-6-15-30)17-31(22)16-18-10-12-19(13-11-18)20-8-3-4-9-21(20)24-26-28-29-27-24/h3-6,8-15,17H,2,7,16H2,1H3,(H,26,27,28,29)
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n/an/a 5.60n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230910
PNG
(CHEMBL306066)
Show SMILES CCCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C26H25N7O2/c1-2-3-10-22-27-25(32-15-6-7-16-32)23(26(34)35)33(22)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)24-28-30-31-29-24/h4-9,11-16H,2-3,10,17H2,1H3,(H,34,35)(H,28,29,30,31)
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n/an/a 7n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230885
PNG
(CHEMBL72453)
Show SMILES CCCc1nc(c(C(N)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(O)=O
Show InChI InChI=1S/C26H24N8O3/c1-2-6-21-28-25(33-14-5-9-20(33)26(36)37)22(23(27)35)34(21)15-16-10-12-17(13-11-16)18-7-3-4-8-19(18)24-29-31-32-30-24/h3-5,7-14H,2,6,15H2,1H3,(H2,27,35)(H,36,37)(H,29,30,31,32)
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n/an/a 8.80n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230918
PNG
(CHEMBL73084)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1ccc(C(O)=O)c1C
Show InChI InChI=1S/C27H25N7O4/c1-3-6-22-28-25(33-14-13-19(16(33)2)26(35)36)23(27(37)38)34(22)15-17-9-11-18(12-10-17)20-7-4-5-8-21(20)24-29-31-32-30-24/h4-5,7-14H,3,6,15H2,1-2H3,(H,35,36)(H,37,38)(H,29,30,31,32)
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n/an/a 9n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230911
PNG
(CHEMBL306949)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(O)=O
Show InChI InChI=1S/C26H23N7O4/c1-2-6-21-27-24(32-14-5-9-20(32)25(34)35)22(26(36)37)33(21)15-16-10-12-17(13-11-16)18-7-3-4-8-19(18)23-28-30-31-29-23/h3-5,7-14H,2,6,15H2,1H3,(H,34,35)(H,36,37)(H,28,29,30,31)
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n/an/a 11n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230918
PNG
(CHEMBL73084)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1ccc(C(O)=O)c1C
Show InChI InChI=1S/C27H25N7O4/c1-3-6-22-28-25(33-14-13-19(16(33)2)26(35)36)23(27(37)38)34(22)15-17-9-11-18(12-10-17)20-7-4-5-8-21(20)24-29-31-32-30-24/h4-5,7-14H,3,6,15H2,1-2H3,(H,35,36)(H,37,38)(H,29,30,31,32)
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n/an/a 11n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230890
PNG
(CHEMBL73646)
Show SMILES CCCc1nc(c(C(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C27H27N7O2/c1-3-9-23-28-26(33-16-7-8-17-33)24(27(35)36-4-2)34(23)18-19-12-14-20(15-13-19)21-10-5-6-11-22(21)25-29-31-32-30-25/h5-8,10-17H,3-4,9,18H2,1-2H3,(H,29,30,31,32)
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n/an/a 12n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230907
PNG
(CHEMBL76393)
Show SMILES CCCc1nc(c(C=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C27H27N7O/c1-4-7-25-28-27(34-18(2)10-11-19(34)3)24(17-35)33(25)16-20-12-14-21(15-13-20)22-8-5-6-9-23(22)26-29-31-32-30-26/h5-6,8-15,17H,4,7,16H2,1-3H3,(H,29,30,31,32)
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n/an/a 14n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230879
PNG
(CHEMBL309094)
Show SMILES CCCc1ccc(C)n1-c1nc(CCC)n(Cc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c1C(=O)OC
Show InChI InChI=1S/C30H33N7O2/c1-5-9-23-18-13-20(3)37(23)29-27(30(38)39-4)36(26(31-29)10-6-2)19-21-14-16-22(17-15-21)24-11-7-8-12-25(24)28-32-34-35-33-28/h7-8,11-18H,5-6,9-10,19H2,1-4H3,(H,32,33,34,35)
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n/an/a 15n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230900
PNG
(CHEMBL73433)
Show SMILES CCCc1nc(c(\C=C(/C)C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C28H27N7O2/c1-3-8-25-29-27(34-15-6-7-16-34)24(17-19(2)28(36)37)35(25)18-20-11-13-21(14-12-20)22-9-4-5-10-23(22)26-30-32-33-31-26/h4-7,9-17H,3,8,18H2,1-2H3,(H,36,37)(H,30,31,32,33)/b19-17+
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n/an/a 18n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230911
PNG
(CHEMBL306949)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(O)=O
Show InChI InChI=1S/C26H23N7O4/c1-2-6-21-27-24(32-14-5-9-20(32)25(34)35)22(26(36)37)33(21)15-16-10-12-17(13-11-16)18-7-3-4-8-19(18)23-28-30-31-29-23/h3-5,7-14H,2,6,15H2,1H3,(H,34,35)(H,36,37)(H,28,29,30,31)
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n/an/a 19n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230916
PNG
(CHEMBL76330)
Show SMILES CCCc1nc(c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1ccc(C(=O)OC)c1C
Show InChI InChI=1S/C29H29N7O4/c1-5-8-24-30-27(35-16-15-21(18(35)2)28(37)39-3)25(29(38)40-4)36(24)17-19-11-13-20(14-12-19)22-9-6-7-10-23(22)26-31-33-34-32-26/h6-7,9-16H,5,8,17H2,1-4H3,(H,31,32,33,34)
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n/an/a 19n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230896
PNG
(CHEMBL308961)
Show SMILES CCCc1nc(c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C28H29N7O2/c1-5-8-24-29-27(35-18(2)11-12-19(35)3)25(28(36)37-4)34(24)17-20-13-15-21(16-14-20)22-9-6-7-10-23(22)26-30-32-33-31-26/h6-7,9-16H,5,8,17H2,1-4H3,(H,30,31,32,33)
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n/an/a 21n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230881
PNG
(CHEMBL308779)
Show SMILES CCCc1nc(c(\C=C\C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C29H29N7O2/c1-4-7-26-30-29(36-19(2)10-11-20(36)3)25(16-17-27(37)38)35(26)18-21-12-14-22(15-13-21)23-8-5-6-9-24(23)28-31-33-34-32-28/h5-6,8-17H,4,7,18H2,1-3H3,(H,37,38)(H,31,32,33,34)/b17-16+
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n/an/a 21n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230913
PNG
(CHEMBL75092)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1ccc(c1)C(=O)OCC
Show InChI InChI=1S/C28H27N7O4/c1-3-7-23-29-26(34-15-14-20(17-34)28(38)39-4-2)24(27(36)37)35(23)16-18-10-12-19(13-11-18)21-8-5-6-9-22(21)25-30-32-33-31-25/h5-6,8-15,17H,3-4,7,16H2,1-2H3,(H,36,37)(H,30,31,32,33)
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n/an/a 22n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230892
PNG
(CHEMBL73725)
Show SMILES CCCc1nc(c(\C=C\C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C30H31N7O2/c1-5-8-27-31-30(37-20(2)11-12-21(37)3)26(17-18-28(38)39-4)36(27)19-22-13-15-23(16-14-22)24-9-6-7-10-25(24)29-32-34-35-33-29/h6-7,9-18H,5,8,19H2,1-4H3,(H,32,33,34,35)/b18-17+
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n/an/a 22n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230920
PNG
(CHEMBL307284)
Show SMILES CCCCc1nc(c(C(=O)c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C32H29N7O/c1-2-3-15-28-33-32(38-20-9-10-21-38)29(30(40)25-11-5-4-6-12-25)39(28)22-23-16-18-24(19-17-23)26-13-7-8-14-27(26)31-34-36-37-35-31/h4-14,16-21H,2-3,15,22H2,1H3,(H,34,35,36,37)
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n/an/a 23n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230878
PNG
(CHEMBL307432)
Show SMILES CCCc1nc(c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C27H29N7O/c1-4-7-25-28-27(34-18(2)10-11-19(34)3)24(17-35)33(25)16-20-12-14-21(15-13-20)22-8-5-6-9-23(22)26-29-31-32-30-26/h5-6,8-15,35H,4,7,16-17H2,1-3H3,(H,29,30,31,32)
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n/an/a 24n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230904
PNG
(CHEMBL306750)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1ccc(c1)C(O)=O
Show InChI InChI=1S/C26H23N7O4/c1-2-5-21-27-24(32-13-12-18(15-32)25(34)35)22(26(36)37)33(21)14-16-8-10-17(11-9-16)19-6-3-4-7-20(19)23-28-30-31-29-23/h3-4,6-13,15H,2,5,14H2,1H3,(H,34,35)(H,36,37)(H,28,29,30,31)
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n/an/a 25n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230905
PNG
(CHEMBL75498)
Show SMILES CCCCc1nc(cn1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C25H25N7/c1-2-3-10-23-26-24(31-15-6-7-16-31)18-32(23)17-19-11-13-20(14-12-19)21-8-4-5-9-22(21)25-27-29-30-28-25/h4-9,11-16,18H,2-3,10,17H2,1H3,(H,27,28,29,30)
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n/an/a 27n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230888
PNG
(CHEMBL306612)
Show SMILES CCCc1nc(c(\C=C\C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C27H25N7O2/c1-2-7-24-28-27(33-16-5-6-17-33)23(14-15-25(35)36)34(24)18-19-10-12-20(13-11-19)21-8-3-4-9-22(21)26-29-31-32-30-26/h3-6,8-17H,2,7,18H2,1H3,(H,35,36)(H,29,30,31,32)/b15-14+
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n/an/a 34n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230878
PNG
(CHEMBL307432)
Show SMILES CCCc1nc(c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C27H29N7O/c1-4-7-25-28-27(34-18(2)10-11-19(34)3)24(17-35)33(25)16-20-12-14-21(15-13-20)22-8-5-6-9-23(22)26-29-31-32-30-26/h5-6,8-15,35H,4,7,16-17H2,1-3H3,(H,29,30,31,32)
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n/an/a 39n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230897
PNG
(CHEMBL275652)
Show SMILES CCCCc1nc(c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)C(F)(F)F
Show InChI InChI=1S/C29H26F3N7O3/c1-3-4-11-23-33-27(38-16-7-10-22(38)25(40)29(30,31)32)24(28(41)42-2)39(23)17-18-12-14-19(15-13-18)20-8-5-6-9-21(20)26-34-36-37-35-26/h5-10,12-16H,3-4,11,17H2,1-2H3,(H,34,35,36,37)
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n/an/a 52n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230895
PNG
(CHEMBL73463)
Show SMILES CCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)OC
Show InChI InChI=1S/C27H24N8O2/c1-3-7-24-29-26(34-15-6-10-22(34)27(36)37-2)23(16-28)35(24)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)25-30-32-33-31-25/h4-6,8-15H,3,7,17H2,1-2H3,(H,30,31,32,33)
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n/an/a 53n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230885
PNG
(CHEMBL72453)
Show SMILES CCCc1nc(c(C(N)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(O)=O
Show InChI InChI=1S/C26H24N8O3/c1-2-6-21-28-25(33-14-5-9-20(33)26(36)37)22(23(27)35)34(21)15-16-10-12-17(13-11-16)18-7-3-4-8-19(18)24-29-31-32-30-24/h3-5,7-14H,2,6,15H2,1H3,(H2,27,35)(H,36,37)(H,29,30,31,32)
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n/an/a 57n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230903
PNG
(CHEMBL75840)
Show SMILES COC(=O)c1c(nc(C2CC2)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C28H27N7O2/c1-17-8-9-18(2)35(17)27-24(28(36)37-3)34(26(29-27)21-14-15-21)16-19-10-12-20(13-11-19)22-6-4-5-7-23(22)25-30-32-33-31-25/h4-13,21H,14-16H2,1-3H3,(H,30,31,32,33)
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n/an/a 66n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230907
PNG
(CHEMBL76393)
Show SMILES CCCc1nc(c(C=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C27H27N7O/c1-4-7-25-28-27(34-18(2)10-11-19(34)3)24(17-35)33(25)16-20-12-14-21(15-13-20)22-8-5-6-9-23(22)26-29-31-32-30-26/h5-6,8-15,17H,4,7,16H2,1-3H3,(H,29,30,31,32)
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n/an/a 71n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230909
PNG
(CHEMBL306852)
Show SMILES CCCc1nc(c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)C(F)(F)F
Show InChI InChI=1S/C28H24F3N7O3/c1-3-7-22-32-26(37-15-6-10-21(37)24(39)28(29,30)31)23(27(40)41-2)38(22)16-17-11-13-18(14-12-17)19-8-4-5-9-20(19)25-33-35-36-34-25/h4-6,8-15H,3,7,16H2,1-2H3,(H,33,34,35,36)
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n/an/a 73n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230886
PNG
(CHEMBL307455)
Show SMILES CCCc1nc(c(C(O)=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1ccc(C(=O)OC)c1C
Show InChI InChI=1S/C28H27N7O4/c1-4-7-23-29-26(34-15-14-20(17(34)2)28(38)39-3)24(27(36)37)35(23)16-18-10-12-19(13-11-18)21-8-5-6-9-22(21)25-30-32-33-31-25/h5-6,8-15H,4,7,16H2,1-3H3,(H,36,37)(H,30,31,32,33)
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n/an/a 82n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM82258
PNG
(CAS_114798-26-4 | Losartan | NSC_3961)
Show SMILES CCCCc1nc(Cl)c(CO)n1Cc1ccc(cc1)-c1ccccc1-c1nnn[nH]1
Show InChI InChI=1S/C22H23ClN6O/c1-2-3-8-20-24-21(23)19(14-30)29(20)13-15-9-11-16(12-10-15)17-6-4-5-7-18(17)22-25-27-28-26-22/h4-7,9-12,30H,2-3,8,13-14H2,1H3,(H,25,26,27,28)
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n/an/a 89n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230903
PNG
(CHEMBL75840)
Show SMILES COC(=O)c1c(nc(C2CC2)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C28H27N7O2/c1-17-8-9-18(2)35(17)27-24(28(36)37-3)34(26(29-27)21-14-15-21)16-19-10-12-20(13-11-19)22-6-4-5-7-23(22)25-30-32-33-31-25/h4-13,21H,14-16H2,1-3H3,(H,30,31,32,33)
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n/an/a>100n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230898
PNG
(CHEMBL312286)
Show SMILES CCCc1nc(c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1ccc(c1)C(=O)OCC
Show InChI InChI=1S/C29H29N7O4/c1-4-8-24-30-27(35-16-15-21(18-35)28(37)40-5-2)25(29(38)39-3)36(24)17-19-11-13-20(14-12-19)22-9-6-7-10-23(22)26-31-33-34-32-26/h6-7,9-16,18H,4-5,8,17H2,1-3H3,(H,31,32,33,34)
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n/an/a>100n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230902
PNG
(CHEMBL75518)
Show SMILES CCCc1nc(c(\C=C(/C)C(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C30H31N7O2/c1-4-10-27-31-29(36-17-8-9-18-36)26(19-21(3)30(38)39-5-2)37(27)20-22-13-15-23(16-14-22)24-11-6-7-12-25(24)28-32-34-35-33-28/h6-9,11-19H,4-5,10,20H2,1-3H3,(H,32,33,34,35)/b21-19+
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n/an/a>100n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230880
PNG
(CHEMBL418893)
Show SMILES CCCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C26H24N8/c1-2-3-10-24-28-26(33-15-6-7-16-33)23(17-27)34(24)18-19-11-13-20(14-12-19)21-8-4-5-9-22(21)25-29-31-32-30-25/h4-9,11-16H,2-3,10,18H2,1H3,(H,29,30,31,32)
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n/an/a>100n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230879
PNG
(CHEMBL309094)
Show SMILES CCCc1ccc(C)n1-c1nc(CCC)n(Cc2ccc(cc2)-c2ccccc2-c2nn[nH]n2)c1C(=O)OC
Show InChI InChI=1S/C30H33N7O2/c1-5-9-23-18-13-20(3)37(23)29-27(30(38)39-4)36(26(31-29)10-6-2)19-21-14-16-22(17-15-21)24-11-7-8-12-25(24)28-32-34-35-33-28/h7-8,11-18H,5-6,9-10,19H2,1-4H3,(H,32,33,34,35)
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n/an/a>100n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230916
PNG
(CHEMBL76330)
Show SMILES CCCc1nc(c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1ccc(C(=O)OC)c1C
Show InChI InChI=1S/C29H29N7O4/c1-5-8-24-30-27(35-16-15-21(18(35)2)28(37)39-3)25(29(38)40-4)36(24)17-19-11-13-20(14-12-19)22-9-6-7-10-23(22)26-31-33-34-32-26/h6-7,9-16H,5,8,17H2,1-4H3,(H,31,32,33,34)
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n/an/a>100n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230894
PNG
(CHEMBL72361)
Show SMILES CCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(O)=O
Show InChI InChI=1S/C26H22N8O2/c1-2-6-23-28-25(33-14-5-9-21(33)26(35)36)22(15-27)34(23)16-17-10-12-18(13-11-17)19-7-3-4-8-20(19)24-29-31-32-30-24/h3-5,7-14H,2,6,16H2,1H3,(H,35,36)(H,29,30,31,32)
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n/an/a 103n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230896
PNG
(CHEMBL308961)
Show SMILES CCCc1nc(c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C28H29N7O2/c1-5-8-24-29-27(35-18(2)11-12-19(35)3)25(28(36)37-4)34(24)17-20-13-15-21(16-14-20)22-9-6-7-10-23(22)26-30-32-33-31-26/h6-7,9-16H,5,8,17H2,1-4H3,(H,30,31,32,33)
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n/an/a 150n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230898
PNG
(CHEMBL312286)
Show SMILES CCCc1nc(c(C(=O)OC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1ccc(c1)C(=O)OCC
Show InChI InChI=1S/C29H29N7O4/c1-4-8-24-30-27(35-16-15-21(18-35)28(37)40-5-2)25(29(38)39-3)36(24)17-19-11-13-20(14-12-19)22-9-6-7-10-23(22)26-31-33-34-32-26/h6-7,9-16,18H,4-5,8,17H2,1-3H3,(H,31,32,33,34)
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n/an/a 158n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230889
PNG
(CHEMBL73564)
Show SMILES CCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)C(F)(F)F
Show InChI InChI=1S/C27H21F3N8O/c1-2-6-23-32-26(37-14-5-9-21(37)24(39)27(28,29)30)22(15-31)38(23)16-17-10-12-18(13-11-17)19-7-3-4-8-20(19)25-33-35-36-34-25/h3-5,7-14H,2,6,16H2,1H3,(H,33,34,35,36)
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n/an/a 171n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230917
PNG
(CHEMBL420198)
Show SMILES CCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(C)ccc1C
Show InChI InChI=1S/C27H26N8/c1-4-7-25-29-27(35-18(2)10-11-19(35)3)24(16-28)34(25)17-20-12-14-21(15-13-20)22-8-5-6-9-23(22)26-30-32-33-31-26/h5-6,8-15H,4,7,17H2,1-3H3,(H,30,31,32,33)
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n/an/a 188n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230880
PNG
(CHEMBL418893)
Show SMILES CCCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C26H24N8/c1-2-3-10-24-28-26(33-15-6-7-16-33)23(17-27)34(24)18-19-11-13-20(14-12-19)21-8-4-5-9-22(21)25-29-31-32-30-25/h4-9,11-16H,2-3,10,18H2,1H3,(H,29,30,31,32)
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n/an/a 209n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230884
PNG
(CHEMBL73358)
Show SMILES CCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(O)C(F)(F)F
Show InChI InChI=1S/C27H23F3N8O/c1-2-6-23-32-26(37-14-5-9-21(37)24(39)27(28,29)30)22(15-31)38(23)16-17-10-12-18(13-11-17)19-7-3-4-8-20(19)25-33-35-36-34-25/h3-5,7-14,24,39H,2,6,16H2,1H3,(H,33,34,35,36)
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n/an/a 233n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230890
PNG
(CHEMBL73646)
Show SMILES CCCc1nc(c(C(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C27H27N7O2/c1-3-9-23-28-26(33-16-7-8-17-33)24(27(35)36-4-2)34(23)18-19-12-14-20(15-13-19)21-10-5-6-11-22(21)25-29-31-32-30-25/h5-8,10-17H,3-4,9,18H2,1-2H3,(H,29,30,31,32)
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n/an/a 330n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor (AT-1) type-1


(RAT)
BDBM50230901
PNG
(CHEMBL72080)
Show SMILES CCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C25H22N8/c1-2-7-23-27-25(32-14-5-6-15-32)22(16-26)33(23)17-18-10-12-19(13-11-18)20-8-3-4-9-21(20)24-28-30-31-29-24/h3-6,8-15H,2,7,17H2,1H3,(H,28,29,30,31)
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n/an/a 332n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against binding of [125I]angiotensin II to rat liver expressing Angiotensin II receptor


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230905
PNG
(CHEMBL75498)
Show SMILES CCCCc1nc(cn1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C25H25N7/c1-2-3-10-23-26-24(31-15-6-7-16-31)18-32(23)17-19-11-13-20(14-12-19)21-8-4-5-9-22(21)25-27-29-30-28-25/h4-9,11-16,18H,2-3,10,17H2,1H3,(H,27,28,29,30)
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n/an/a 400n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230914
PNG
(CHEMBL431390)
Show SMILES CCCc1nc(c(C(=O)OCC)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1c(Cl)ccc1Cl
Show InChI InChI=1S/C27H25Cl2N7O2/c1-3-7-23-30-26(36-21(28)14-15-22(36)29)24(27(37)38-4-2)35(23)16-17-10-12-18(13-11-17)19-8-5-6-9-20(19)25-31-33-34-32-25/h5-6,8-15H,3-4,7,16H2,1-2H3,(H,31,32,33,34)
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n/an/a 430n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230889
PNG
(CHEMBL73564)
Show SMILES CCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)C(F)(F)F
Show InChI InChI=1S/C27H21F3N8O/c1-2-6-23-32-26(37-14-5-9-21(37)24(39)27(28,29)30)22(15-31)38(23)16-17-10-12-18(13-11-17)19-7-3-4-8-20(19)25-33-35-36-34-25/h3-5,7-14H,2,6,16H2,1H3,(H,33,34,35,36)
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n/an/a 780n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230901
PNG
(CHEMBL72080)
Show SMILES CCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C25H22N8/c1-2-7-23-27-25(32-14-5-6-15-32)22(16-26)33(23)17-18-10-12-19(13-11-18)20-8-3-4-9-21(20)24-28-30-31-29-24/h3-6,8-15H,2,7,17H2,1H3,(H,28,29,30,31)
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n/an/a 1.50E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230884
PNG
(CHEMBL73358)
Show SMILES CCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(O)C(F)(F)F
Show InChI InChI=1S/C27H23F3N8O/c1-2-6-23-32-26(37-14-5-9-21(37)24(39)27(28,29)30)22(15-31)38(23)16-17-10-12-18(13-11-17)19-7-3-4-8-20(19)25-33-35-36-34-25/h3-5,7-14,24,39H,2,6,16H2,1H3,(H,33,34,35,36)
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n/an/a 2.20E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230895
PNG
(CHEMBL73463)
Show SMILES CCCc1nc(c(C#N)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1C(=O)OC
Show InChI InChI=1S/C27H24N8O2/c1-3-7-24-29-26(34-15-6-10-22(34)27(36)37-2)23(16-28)35(24)17-18-11-13-19(14-12-18)20-8-4-5-9-21(20)25-30-32-33-31-25/h4-6,8-15H,3,7,17H2,1-2H3,(H,30,31,32,33)
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PC sid
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n/an/a 2.40E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230899
PNG
(CHEMBL75935)
Show SMILES CCCc1nc(cn1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C24H23N7/c1-2-7-22-25-23(30-14-5-6-15-30)17-31(22)16-18-10-12-19(13-11-18)20-8-3-4-9-21(20)24-26-28-29-27-24/h3-6,8-15,17H,2,7,16H2,1H3,(H,26,27,28,29)
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n/an/a 3.50E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
Angiotensin II receptor


(Homo sapiens (Human))
BDBM50230920
PNG
(CHEMBL307284)
Show SMILES CCCCc1nc(c(C(=O)c2ccccc2)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1)-n1cccc1
Show InChI InChI=1S/C32H29N7O/c1-2-3-15-28-33-32(38-20-9-10-21-38)29(30(40)25-11-5-4-6-12-25)39(28)22-23-16-18-24(19-17-23)26-13-7-8-14-27(26)31-34-36-37-35-31/h4-14,16-21H,2-3,15,22H2,1H3,(H,34,35,36,37)
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n/an/a 5.40E+3n/an/an/an/an/an/a



Warner-Lambert Company

Curated by ChEMBL


Assay Description
Inhibitory concentration against [125I]angiotensin II(AII) induced contraction in rabbit aorta by 50%


J Med Chem 36: 2253-65 (1993)

More data for this
Ligand-Target Pair
* indicates data uncertainty>20%