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PubMed code 8632428

Compile data set for download or QSAR
Found 63 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22916
PNG
(5-{3-[(4-iodophenyl)methoxy]propyl}-1H-imidazole |...)
Show SMILES Ic1ccc(COCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
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1n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050173
PNG
(4-[3-(3-Iodo-benzyloxy)-propyl]-1H-imidazole | CHE...)
Show SMILES Ic1cccc(COCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C13H15IN2O/c14-12-4-1-3-11(7-12)9-17-6-2-5-13-8-15-10-16-13/h1,3-4,7-8,10H,2,5-6,9H2,(H,15,16)
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1.30n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050180
PNG
(4-[3-(4-Bromo-benzyloxy)-propyl]-1H-imidazole | CH...)
Show SMILES Brc1ccc(COCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H15BrN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
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1.30n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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2n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity against histamine H3 receptor on rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050178
PNG
(4-[3-(3-Iodo-phenoxy)-propyl]-1H-imidazole | CHEMB...)
Show SMILES Ic1cccc(OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C12H13IN2O/c13-10-3-1-5-12(7-10)16-6-2-4-11-8-14-9-15-11/h1,3,5,7-9H,2,4,6H2,(H,14,15)
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2.51n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050181
PNG
(4-[3-(4-Iodo-phenoxy)-propyl]-1H-imidazole | CHEMB...)
Show SMILES Ic1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C12H13IN2O/c13-10-3-5-12(6-4-10)16-7-1-2-11-8-14-9-15-11/h3-6,8-9H,1-2,7H2,(H,14,15)
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3.20n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22914
PNG
(CHEMBL260374 | N-cyclohexyl-4-(1H-imidazol-5-yl)pi...)
Show SMILES S=C(NC1CCCCC1)N1CCC(CC1)c1cnc[nH]1
Show InChI InChI=1S/C15H24N4S/c20-15(18-13-4-2-1-3-5-13)19-8-6-12(7-9-19)14-10-16-11-17-14/h10-13H,1-9H2,(H,16,17)(H,18,20)
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3.98n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050179
PNG
(3-Iodo-benzoic acid 3-(1H-imidazol-4-yl)-propyl es...)
Show SMILES Ic1cccc(c1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13IN2O2/c14-11-4-1-3-10(7-11)13(17)18-6-2-5-12-8-15-9-16-12/h1,3-4,7-9H,2,5-6H2,(H,15,16)
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3.98n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22916
PNG
(5-{3-[(4-iodophenyl)methoxy]propyl}-1H-imidazole |...)
Show SMILES Ic1ccc(COCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
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5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050172
PNG
(3-Iodo-4-methyl-benzoic acid 3-(1H-imidazol-4-yl)-...)
Show SMILES Cc1ccc(cc1I)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H15IN2O2/c1-10-4-5-11(7-13(10)15)14(18)19-6-2-3-12-8-16-9-17-12/h4-5,7-9H,2-3,6H2,1H3,(H,16,17)
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5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22916
PNG
(5-{3-[(4-iodophenyl)methoxy]propyl}-1H-imidazole |...)
Show SMILES Ic1ccc(COCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H15IN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
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5n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050173
PNG
(4-[3-(3-Iodo-benzyloxy)-propyl]-1H-imidazole | CHE...)
Show SMILES Ic1cccc(COCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C13H15IN2O/c14-12-4-1-3-11(7-12)9-17-6-2-5-13-8-15-10-16-13/h1,3-4,7-8,10H,2,5-6,9H2,(H,15,16)
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6.31n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050173
PNG
(4-[3-(3-Iodo-benzyloxy)-propyl]-1H-imidazole | CHE...)
Show SMILES Ic1cccc(COCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C13H15IN2O/c14-12-4-1-3-11(7-12)9-17-6-2-5-13-8-15-10-16-13/h1,3-4,7-8,10H,2,5-6,9H2,(H,15,16)
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7n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050175
PNG
(4-{3-[3-(4-Iodo-phenyl)-propoxy]-propyl}-1H-imidaz...)
Show SMILES Ic1ccc(CCCOCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H19IN2O/c16-14-7-5-13(6-8-14)3-1-9-19-10-2-4-15-11-17-12-18-15/h5-8,11-12H,1-4,9-10H2,(H,17,18)
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7.90n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050171
PNG
((3-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C13H14IN3O2/c14-10-3-1-4-11(7-10)17-13(18)19-6-2-5-12-8-15-9-16-12/h1,3-4,7-9H,2,5-6H2,(H,15,16)(H,17,18)
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7.90n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050166
PNG
(4-Iodo-benzoic acid 3-(1H-imidazol-4-yl)-propyl es...)
Show SMILES Ic1ccc(cc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13IN2O2/c14-11-5-3-10(4-6-11)13(17)18-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)
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7.90n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050170
PNG
((4-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14IN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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7.94n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050170
PNG
((4-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14IN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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10n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050170
PNG
((4-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(NC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H14IN3O2/c14-10-3-5-11(6-4-10)17-13(18)19-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)(H,17,18)
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11n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050183
PNG
((4-Iodo-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16IN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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12n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050183
PNG
((4-Iodo-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16IN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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12.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050180
PNG
(4-[3-(4-Bromo-benzyloxy)-propyl]-1H-imidazole | CH...)
Show SMILES Brc1ccc(COCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H15BrN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
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12.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050169
PNG
((4-Iodo-phenyl)-acetic acid 3-(1H-imidazol-4-yl)-p...)
Show SMILES Ic1ccc(CC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H15IN2O2/c15-12-5-3-11(4-6-12)8-14(18)19-7-1-2-13-9-16-10-17-13/h3-6,9-10H,1-2,7-8H2,(H,16,17)
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12.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050169
PNG
((4-Iodo-phenyl)-acetic acid 3-(1H-imidazol-4-yl)-p...)
Show SMILES Ic1ccc(CC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H15IN2O2/c15-12-5-3-11(4-6-12)8-14(18)19-7-1-2-13-9-16-10-17-13/h3-6,9-10H,1-2,7-8H2,(H,16,17)
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13n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050183
PNG
((4-Iodo-benzyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccc(CNC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H16IN3O2/c15-12-5-3-11(4-6-12)8-17-14(19)20-7-1-2-13-9-16-10-18-13/h3-6,9-10H,1-2,7-8H2,(H,16,18)(H,17,19)
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13n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050180
PNG
(4-[3-(4-Bromo-benzyloxy)-propyl]-1H-imidazole | CH...)
Show SMILES Brc1ccc(COCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C13H15BrN2O/c14-12-5-3-11(4-6-12)9-17-7-1-2-13-8-15-10-16-13/h3-6,8,10H,1-2,7,9H2,(H,15,16)
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14n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050169
PNG
((4-Iodo-phenyl)-acetic acid 3-(1H-imidazol-4-yl)-p...)
Show SMILES Ic1ccc(CC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C14H15IN2O2/c15-12-5-3-11(4-6-12)8-14(18)19-7-1-2-13-9-16-10-17-13/h3-6,9-10H,1-2,7-8H2,(H,16,17)
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14n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050171
PNG
((3-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C13H14IN3O2/c14-10-3-1-4-11(7-10)17-13(18)19-6-2-5-12-8-15-9-16-12/h1,3-4,7-9H,2,5-6H2,(H,15,16)(H,17,18)
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15.8n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050178
PNG
(4-[3-(3-Iodo-phenoxy)-propyl]-1H-imidazole | CHEMB...)
Show SMILES Ic1cccc(OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C12H13IN2O/c13-10-3-1-5-12(7-10)16-6-2-4-11-8-14-9-15-11/h1,3,5,7-9H,2,4,6H2,(H,14,15)
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16n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050171
PNG
((3-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1cccc(NC(=O)OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C13H14IN3O2/c14-10-3-1-4-11(7-10)17-13(18)19-6-2-5-12-8-15-9-16-12/h1,3-4,7-9H,2,5-6H2,(H,15,16)(H,17,18)
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16n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050178
PNG
(4-[3-(3-Iodo-phenoxy)-propyl]-1H-imidazole | CHEMB...)
Show SMILES Ic1cccc(OCCCc2cnc[nH]2)c1
Show InChI InChI=1S/C12H13IN2O/c13-10-3-1-5-12(7-10)16-6-2-4-11-8-14-9-15-11/h1,3,5,7-9H,2,4,6H2,(H,14,15)
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17n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050181
PNG
(4-[3-(4-Iodo-phenoxy)-propyl]-1H-imidazole | CHEMB...)
Show SMILES Ic1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C12H13IN2O/c13-10-3-5-12(6-4-10)16-7-1-2-11-8-14-9-15-11/h3-6,8-9H,1-2,7H2,(H,14,15)
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19.9n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050166
PNG
(4-Iodo-benzoic acid 3-(1H-imidazol-4-yl)-propyl es...)
Show SMILES Ic1ccc(cc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13IN2O2/c14-11-5-3-10(4-6-11)13(17)18-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)
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19.9n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050182
PNG
(2-Iodo-benzoic acid 3-(1H-imidazol-4-yl)-propyl es...)
Show SMILES Ic1ccccc1C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13IN2O2/c14-12-6-2-1-5-11(12)13(17)18-7-3-4-10-8-15-9-16-10/h1-2,5-6,8-9H,3-4,7H2,(H,15,16)
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20n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050166
PNG
(4-Iodo-benzoic acid 3-(1H-imidazol-4-yl)-propyl es...)
Show SMILES Ic1ccc(cc1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13IN2O2/c14-11-5-3-10(4-6-11)13(17)18-7-1-2-12-8-15-9-16-12/h3-6,8-9H,1-2,7H2,(H,15,16)
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20n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050181
PNG
(4-[3-(4-Iodo-phenoxy)-propyl]-1H-imidazole | CHEMB...)
Show SMILES Ic1ccc(OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C12H13IN2O/c13-10-3-5-12(6-4-10)16-7-1-2-11-8-14-9-15-11/h3-6,8-9H,1-2,7H2,(H,14,15)
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22n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050177
PNG
((2-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H14IN3O2/c14-11-5-1-2-6-12(11)17-13(18)19-7-3-4-10-8-15-9-16-10/h1-2,5-6,8-9H,3-4,7H2,(H,15,16)(H,17,18)
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25n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050179
PNG
(3-Iodo-benzoic acid 3-(1H-imidazol-4-yl)-propyl es...)
Show SMILES Ic1cccc(c1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13IN2O2/c14-11-4-1-3-10(7-11)13(17)18-6-2-5-12-8-15-9-16-12/h1,3-4,7-9H,2,5-6H2,(H,15,16)
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25n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050177
PNG
((2-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H14IN3O2/c14-11-5-1-2-6-12(11)17-13(18)19-7-3-4-10-8-15-9-16-10/h1-2,5-6,8-9H,3-4,7H2,(H,15,16)(H,17,18)
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25n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050179
PNG
(3-Iodo-benzoic acid 3-(1H-imidazol-4-yl)-propyl es...)
Show SMILES Ic1cccc(c1)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13IN2O2/c14-11-4-1-3-10(7-11)13(17)18-6-2-5-12-8-15-9-16-12/h1,3-4,7-9H,2,5-6H2,(H,15,16)
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25n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050177
PNG
((2-Iodo-phenyl)-carbamic acid 3-(1H-imidazol-4-yl)...)
Show SMILES Ic1ccccc1NC(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H14IN3O2/c14-11-5-1-2-6-12(11)17-13(18)19-7-3-4-10-8-15-9-16-10/h1-2,5-6,8-9H,3-4,7H2,(H,15,16)(H,17,18)
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25.1n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050172
PNG
(3-Iodo-4-methyl-benzoic acid 3-(1H-imidazol-4-yl)-...)
Show SMILES Cc1ccc(cc1I)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H15IN2O2/c1-10-4-5-11(7-13(10)15)14(18)19-6-2-3-12-8-16-9-17-12/h4-5,7-9H,2-3,6H2,1H3,(H,16,17)
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30n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050172
PNG
(3-Iodo-4-methyl-benzoic acid 3-(1H-imidazol-4-yl)-...)
Show SMILES Cc1ccc(cc1I)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C14H15IN2O2/c1-10-4-5-11(7-13(10)15)14(18)19-6-2-3-12-8-16-9-17-12/h4-5,7-9H,2-3,6H2,1H3,(H,16,17)
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31.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050175
PNG
(4-{3-[3-(4-Iodo-phenyl)-propoxy]-propyl}-1H-imidaz...)
Show SMILES Ic1ccc(CCCOCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H19IN2O/c16-14-7-5-13(6-8-14)3-1-9-19-10-2-4-15-11-17-12-18-15/h5-8,11-12H,1-4,9-10H2,(H,17,18)
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31.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050176
PNG
(4-Amino-3,5-diiodo-benzoic acid 3-(1H-imidazol-4-y...)
Show SMILES Nc1c(I)cc(cc1I)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13I2N3O2/c14-10-4-8(5-11(15)12(10)16)13(19)20-3-1-2-9-6-17-7-18-9/h4-7H,1-3,16H2,(H,17,18)
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31.6n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050165
PNG
(4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl...)
Show SMILES Ic1ccc(CCCC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C16H19IN2O2/c17-14-8-6-13(7-9-14)3-1-5-16(20)21-10-2-4-15-11-18-12-19-15/h6-9,11-12H,1-5,10H2,(H,18,19)
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32n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050175
PNG
(4-{3-[3-(4-Iodo-phenyl)-propoxy]-propyl}-1H-imidaz...)
Show SMILES Ic1ccc(CCCOCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H19IN2O/c16-14-7-5-13(6-8-14)3-1-9-19-10-2-4-15-11-17-12-18-15/h5-8,11-12H,1-4,9-10H2,(H,17,18)
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35n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050182
PNG
(2-Iodo-benzoic acid 3-(1H-imidazol-4-yl)-propyl es...)
Show SMILES Ic1ccccc1C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13IN2O2/c14-12-6-2-1-5-11(12)13(17)18-7-3-4-10-8-15-9-16-10/h1-2,5-6,8-9H,3-4,7H2,(H,15,16)
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39n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050165
PNG
(4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl...)
Show SMILES Ic1ccc(CCCC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C16H19IN2O2/c17-14-8-6-13(7-9-14)3-1-5-16(20)21-10-2-4-15-11-18-12-19-15/h6-9,11-12H,1-5,10H2,(H,18,19)
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39.8n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050182
PNG
(2-Iodo-benzoic acid 3-(1H-imidazol-4-yl)-propyl es...)
Show SMILES Ic1ccccc1C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13IN2O2/c14-12-6-2-1-5-11(12)13(17)18-7-3-4-10-8-15-9-16-10/h1-2,5-6,8-9H,3-4,7H2,(H,15,16)
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39.8n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22884
PNG
(2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H...)
Show SMILES Cc1nc[nH]c1CSCCN=C(N)NCCCc1cnc[nH]1
Show InChI InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18)
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40n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050165
PNG
(4-(4-Iodo-phenyl)-butyric acid 3-(1H-imidazol-4-yl...)
Show SMILES Ic1ccc(CCCC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C16H19IN2O2/c17-14-8-6-13(7-9-14)3-1-5-16(20)21-10-2-4-15-11-18-12-19-15/h6-9,11-12H,1-5,10H2,(H,18,19)
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41n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050168
PNG
(3-(4-Iodo-phenyl)-propionic acid 3-(1H-imidazol-4-...)
Show SMILES Ic1ccc(CCC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H17IN2O2/c16-13-6-3-12(4-7-13)5-8-15(19)20-9-1-2-14-10-17-11-18-14/h3-4,6-7,10-11H,1-2,5,8-9H2,(H,17,18)
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47n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050168
PNG
(3-(4-Iodo-phenyl)-propionic acid 3-(1H-imidazol-4-...)
Show SMILES Ic1ccc(CCC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H17IN2O2/c16-13-6-3-12(4-7-13)5-8-15(19)20-9-1-2-14-10-17-11-18-14/h3-4,6-7,10-11H,1-2,5,8-9H2,(H,17,18)
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50n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM22884
PNG
(2-[3-(1H-imidazol-5-yl)propyl]-1-(2-{[(5-methyl-1H...)
Show SMILES Cc1nc[nH]c1CSCCN=C(N)NCCCc1cnc[nH]1
Show InChI InChI=1S/C14H23N7S/c1-11-13(21-10-19-11)8-22-6-5-18-14(15)17-4-2-3-12-7-16-9-20-12/h7,9-10H,2-6,8H2,1H3,(H,16,20)(H,19,21)(H3,15,17,18)
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63.1n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050168
PNG
(3-(4-Iodo-phenyl)-propionic acid 3-(1H-imidazol-4-...)
Show SMILES Ic1ccc(CCC(=O)OCCCc2cnc[nH]2)cc1
Show InChI InChI=1S/C15H17IN2O2/c16-13-6-3-12(4-7-13)5-8-15(19)20-9-1-2-14-10-17-11-18-14/h3-4,6-7,10-11H,1-2,5,8-9H2,(H,17,18)
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79.4n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050176
PNG
(4-Amino-3,5-diiodo-benzoic acid 3-(1H-imidazol-4-y...)
Show SMILES Nc1c(I)cc(cc1I)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13I2N3O2/c14-10-4-8(5-11(15)12(10)16)13(19)20-3-1-2-9-6-17-7-18-9/h4-7H,1-3,16H2,(H,17,18)
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146n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050176
PNG
(4-Amino-3,5-diiodo-benzoic acid 3-(1H-imidazol-4-y...)
Show SMILES Nc1c(I)cc(cc1I)C(=O)OCCCc1cnc[nH]1
Show InChI InChI=1S/C13H13I2N3O2/c14-10-4-8(5-11(15)12(10)16)13(19)20-3-1-2-9-6-17-7-18-9/h4-7H,1-3,16H2,(H,17,18)
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158n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050174
PNG
(3-(3-Iodo-4-methoxy-phenyl)-propionic acid 3-(1H-i...)
Show SMILES COc1ccc(CCC(=O)OCCCc2cnc[nH]2)cc1I
Show InChI InChI=1S/C16H19IN2O3/c1-21-15-6-4-12(9-14(15)17)5-7-16(20)22-8-2-3-13-10-18-11-19-13/h4,6,9-11H,2-3,5,7-8H2,1H3,(H,18,19)
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200n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050174
PNG
(3-(3-Iodo-4-methoxy-phenyl)-propionic acid 3-(1H-i...)
Show SMILES COc1ccc(CCC(=O)OCCCc2cnc[nH]2)cc1I
Show InChI InChI=1S/C16H19IN2O3/c1-21-15-6-4-12(9-14(15)17)5-7-16(20)22-8-2-3-13-10-18-11-19-13/h4,6,9-11H,2-3,5,7-8H2,1H3,(H,18,19)
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232n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50050174
PNG
(3-(3-Iodo-4-methoxy-phenyl)-propionic acid 3-(1H-i...)
Show SMILES COc1ccc(CCC(=O)OCCCc2cnc[nH]2)cc1I
Show InChI InChI=1S/C16H19IN2O3/c1-21-15-6-4-12(9-14(15)17)5-7-16(20)22-8-2-3-13-10-18-11-19-13/h4,6,9-11H,2-3,5,7-8H2,1H3,(H,18,19)
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251n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50408042
PNG
(CHEMBL555594)
Show SMILES OCCCc1cnc[nH]1
Show InChI InChI=1S/C6H10N2O/c9-3-1-2-6-4-7-5-8-6/h4-5,9H,1-3H2,(H,7,8)
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398n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
In vitro antagonistic activity tested against Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
Histamine H3 receptor


(Rattus norvegicus (rat))
BDBM50408042
PNG
(CHEMBL555594)
Show SMILES OCCCc1cnc[nH]1
Show InChI InChI=1S/C6H10N2O/c9-3-1-2-6-4-7-5-8-6/h4-5,9H,1-3H2,(H,7,8)
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631n/an/an/an/an/an/an/an/a



Freie Universität Berlin

Curated by ChEMBL


Assay Description
Binding affinity towards Histamine H3 receptor on synaptosomes from rat cerebral cortex


J Med Chem 39: 1220-6 (1996)


Article DOI: 10.1021/jm9504767
BindingDB Entry DOI: 10.7270/Q28K7855
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%