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PubMed code 8893829

Compile data set for download or QSAR
Found 13 hits of Enzyme Inhibition Constant Data   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054245
PNG
(5-Chloro-N-cyclopropylmethyl-2-methyl-N-propyl-N''...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Cl
Show InChI InChI=1S/C18H20Cl4N4/c1-3-6-26(9-11-4-5-11)18-15(22)17(23-10(2)24-18)25-16-13(20)7-12(19)8-14(16)21/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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PubMed
1.70n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054252
PNG
(5-Bromo-N-cyclopropylmethyl-2-methyl-N-propyl-N'-(...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1Br
Show InChI InChI=1S/C18H20BrCl3N4/c1-3-6-26(9-11-4-5-11)18-15(19)17(23-10(2)24-18)25-16-13(21)7-12(20)8-14(16)22/h7-8,11H,3-6,9H2,1-2H3,(H,23,24,25)
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2n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054250
PNG
(CHEMBL306482 | N-Cyclopropylmethyl-2,5-dimethyl-N-...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C
Show InChI InChI=1S/C19H23Cl3N4/c1-4-7-26(10-13-5-6-13)19-11(2)18(23-12(3)24-19)25-17-15(21)8-14(20)9-16(17)22/h8-9,13H,4-7,10H2,1-3H3,(H,23,24,25)
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2.30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054248
PNG
(2,5-Dimethyl-N,N-dipropyl-N'-(2,4,6-trichloro-phen...)
Show SMILES CCCN(CCC)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1C
Show InChI InChI=1S/C18H23Cl3N4/c1-5-7-25(8-6-2)18-11(3)17(22-12(4)23-18)24-16-14(20)9-13(19)10-15(16)21/h9-10H,5-8H2,1-4H3,(H,22,23,24)
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2.5n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054253
PNG
(CHEMBL77716 | N-Cyclopropylmethyl-5-ethyl-2-methyl...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)c1CC
Show InChI InChI=1S/C20H25Cl3N4/c1-4-8-27(11-13-6-7-13)20-15(5-2)19(24-12(3)25-20)26-18-16(22)9-14(21)10-17(18)23/h9-10,13H,4-8,11H2,1-3H3,(H,24,25,26)
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3.80n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054246
PNG
(CHEMBL77006 | N-Cyclopropylmethyl-2-methyl-N-propy...)
Show SMILES CCCN(CC1CC1)c1cc(Nc2c(Cl)cc(Cl)cc2Cl)nc(C)n1
Show InChI InChI=1S/C18H21Cl3N4/c1-3-6-25(10-12-4-5-12)17-9-16(22-11(2)23-17)24-18-14(20)7-13(19)8-15(18)21/h7-9,12H,3-6,10H2,1-2H3,(H,22,23,24)
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30n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054225
PNG
(CHEMBL306618 | N-Cyclopropylmethyl-6-methyl-N-prop...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(Nc2c(C)cc(C)cc2C)n1
Show InChI InChI=1S/C20H29N5/c1-6-9-25(12-17-7-8-17)20-22-16(5)21-19(24-20)23-18-14(3)10-13(2)11-15(18)4/h10-11,17H,6-9,12H2,1-5H3,(H,21,22,23,24)
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57n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054249
PNG
(CHEMBL140175 | N*4*-Cyclopropylmethyl-6-methyl-N*4...)
Show SMILES CCCN(CC1CC1)c1cc(C)nc(Nc2c(Cl)cc(Cl)cc2Cl)n1
Show InChI InChI=1S/C18H21Cl3N4/c1-3-6-25(10-12-4-5-12)16-7-11(2)22-18(23-16)24-17-14(20)8-13(19)9-15(17)21/h7-9,12H,3-6,10H2,1-2H3,(H,22,23,24)
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70n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054247
PNG
(CHEMBL344805 | N-Cyclopropylmethyl-2,5,N'-trimethy...)
Show SMILES CCCN(CC1CC1)c1nc(C)nc(N(C)c2c(Cl)cc(Cl)cc2Cl)c1C
Show InChI InChI=1S/C20H25Cl3N4/c1-5-8-27(11-14-6-7-14)20-12(2)19(24-13(3)25-20)26(4)18-16(22)9-15(21)10-17(18)23/h9-10,14H,5-8,11H2,1-4H3
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150n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054244
PNG
(CHEMBL134475 | N-Cyclopropylmethyl-2-methyl-N-prop...)
Show SMILES CCCN(CC1CC1)c1cc(Nc2cc(Cl)c(Cl)cc2Cl)nc(C)n1
Show InChI InChI=1S/C18H21Cl3N4/c1-3-6-25(10-12-4-5-12)18-9-17(22-11(2)23-18)24-16-8-14(20)13(19)7-15(16)21/h7-9,12H,3-6,10H2,1-2H3,(H,22,23,24)
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253n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054255
PNG
(CHEMBL80806 | N-Cyclopropylmethyl-2-methyl-N-propy...)
Show SMILES CCCN(CC1CC1)c1cc(Nc2c(C)cc(C)cc2C)nc(C)n1
Show InChI InChI=1S/C21H30N4/c1-6-9-25(13-18-7-8-18)20-12-19(22-17(5)23-20)24-21-15(3)10-14(2)11-16(21)4/h10-12,18H,6-9,13H2,1-5H3,(H,22,23,24)
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1.39E+3n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054251
PNG
(CHEMBL138687 | N*2*-Cyclopropylmethyl-6-methyl-N*2...)
Show SMILES CCCN(CC1CC1)c1nc(C)cc(Nc2c(Cl)cc(Cl)cc2Cl)n1
Show InChI InChI=1S/C18H21Cl3N4/c1-3-6-25(10-12-4-5-12)18-22-11(2)7-16(24-18)23-17-14(20)8-13(19)9-15(17)21/h7-9,12H,3-6,10H2,1-2H3,(H,22,23,24)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
Corticotropin releasing factor receptor 1


(Homo sapiens (Human))
BDBM50054254
PNG
(CHEMBL136593 | N-Cyclopropylmethyl-N-propyl-N'-(2,...)
Show SMILES CCCN(CC1CC1)c1cc(Nc2c(Cl)cc(Cl)cc2Cl)ncn1
Show InChI InChI=1S/C17H19Cl3N4/c1-2-5-24(9-11-3-4-11)16-8-15(21-10-22-16)23-17-13(19)6-12(18)7-14(17)20/h6-8,10-11H,2-5,9H2,1H3,(H,21,22,23)
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>1.00E+4n/an/an/an/an/an/an/an/a



Neurocrine Biosciences

Curated by ChEMBL


Assay Description
Inhibition of [125I]-CRF binding to human Corticotropin releasing factor receptor 1 tested at 6-12 doses


J Med Chem 39: 4358-60 (1996)


Article DOI: 10.1021/jm960149e
BindingDB Entry DOI: 10.7270/Q29022V6
More data for this
Ligand-Target Pair
* indicates data uncertainty>20%