Reaction Details Report a problem with these data
Cell Reactant:
v-Src SH2 Domain
Syringe Reactant:
BDBM22599
Meas. Tech.:
Isothermal Titration Calorimetry
Entry Date.:
06/14/08
ΔG°:
-22.7±n/a (kJ/mole)
pH:
6±n/a
Log10Kb:
3.4
Temperature:
298.15±n/a (K)
ΔHobs :
-19±0.56 (kJ/mole)
Corrected for ΔHioniz:
no
ΔS° :
0.0124±n/a (kJ/mole-K)
Comments:
ITC data were obtained through competition experiments using high affinity peptide (PQpYEEIPI) as the competitor.
Citation
Taylor, JD; Gilbert, PJ; Williams, MA; Pitt, WR; Ladbury, JE Identification of novel fragment compounds targeted against the pY pocket of v-Src SH2 by computational and NMR screening and thermodynamic evaluation. Proteins 67:981-90 (2007) [PubMed] Article
Cell React
Name:
Tyrosine-protein kinase transforming protein Src
Synonyms:
SRC_RSVSA | V-SRC | p60-Src | v-Src SH2 Domain
Type:
SH2 Domain
Mol. Mass.:
58884.32
Organism:
Avian leukosis virus (RSA)
Description:
P00524
Residue:
526
Sequence:
MGSSKSKPKDPSQRRCSLEPPDSTHHGGFPASQTPNKTAAPDTHRTPSRSFGTVATEPKLFGGFNTSDTVTSPQRAGALAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLTTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNPENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFSSLQQLVAYYSKHADGLCHRLTNVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGEMGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMGNGEVLDRVERGYRMPCPPECPESLHDLMCQCWRRDPEERPTFEYLQAQLLPACVLEVAE