Reaction Details  Report a problem with these data
Cell Reactant:
Lipoxygenase type I-B (LOX)
Syringe Reactant:
BDBM50381226
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
10/01/15
ΔG°:
-33.9±0 (kJ/mole)
pH:
8±0
Temperature:
298.15±0 (K)
ΔH° :
1930±0 (kJ/mole)
ΔS° :
6.57±0 (kJ/mole-K)
Citation
 Tomy, MJ; Sharanya, CS; Dileep, KV; Prasanth, S; Sabu, A; Sadasivan, C; Haridas, M Derivatives form better lipoxygenase inhibitors than piperine: in vitro and in silico study. Chem Biol Drug Des 85:715-21 (2015) [PubMed]  Article
Cell React
Name:
Lipoxygenase type I-B (LOX)
Synonyms:
LOX1.2 | LOX2 | LOX2_SOYBN
Type:
Protein
Mol. Mass.:
97147.48
Organism:
Glycine max (Soybean)
Description:
n/a
Residue:
865
Sequence:
MFSVPGVSGILNRGGGHKIKGTVVLMRKNVLDFNSVADLTKGNVGGLIGTGLNVVGSTLDNLTAFLGRSVALQLISATKPLANGKGKVGKDTFLEGIIVSLPTLGAGESAFNIQFEWDESMGIPGAFYIKNYMQVEFYLKSLTLEDVPNQGTIRFVCNSWVYNTKLYKSVRIFFANHTYVPSETPAALVGYREEELKNLRGDGKGERKEHDRIYDYDVYNDLGNPDHGENFARPILGGSSTHPYPRRGRTGRYPTRKDQNSEKPGEVYVPRDENFGHLKSSDFLAYGIKSLSQYVLPAFESVFDLNFTPNEFDSFQDVRDLHEGGIKLPTEVISTIMPLPVVKELFRTDGEQVLKFPPPHVIQVSKSAWMTDEEFAREMVAGVNPCVIRGLQEFPPKSNLDPTIYGEQTSKITADALDLDGYTVDEALASRRLFMLDYHDVFMPYIRRINQTYAKAYATRTILFLRENGTLKPVAIELSLPHPAGDLSGAVSQVILPAKEGVESTIWLLAKAYVVVNDSCYHQLMSHWLNTHAVIEPFIIATNRHLSALHPIYKLLTPHYRDTMNINALARQSLINADGIIEKSFLPSKHSVEMSSAVYKNWVFTDQALPADLIKRGVAIKDPSAPHGLRLLIEDYPYAVDGLEIWAAIKTWVQEYVSLYYARDDDVKPDSELQQWWKEAVEKGHGDLKDKPWWPKLQTIEELVEICTIIIWTASALHAAVNFGQYPYGGFILNRPTSSRRLLPEKGTPEYEEMVKSHQKAYLRTITSKFQTLVDLSVIEILSRHASDEVYLGQRDNPHWTSDSKALQAFQKFGNKLKEIEEKLARKNNDQSLSNRLGPVQLPYTLLHPNSEGLTCRGIPNSISI
  
Syringe React
Name:
BDBM50381226
Synonyms:
PIPERIC ACID
Type:
Small organic molecule
Emp. Form.:
C12H10O4
Mol. Mass.:
218.2054
SMILES:
OC(=O)\C=C\C=C\c1ccc2OCOc2c1
Structure:
Search PDB for entries with ligand similarity: