Reaction Details  Report a problem with these data
Cell Reactant:
C-terminal-binding protein 2 (CtBP2)
Syringe Reactant:
BDBM154571
Meas. Tech.:
Enzyme Inhibition
Entry Date.:
10/15/15
ΔG°:
-3.35±0 (kcal/mole)
pH:
8.5±0
Temperature:
293.15±0 (K)
ΔH° :
-3.35±0.33 (kJ/mole)
Citation
 Hilbert, BJ; Morris, BL; Ellis, KC; Paulsen, JL; Schiffer, CA; Grossman, SR; Royer, WE Structure-guided design of a high affinity inhibitor to human CtBP. ACS Chem Biol 10:1118-27 (2015) [PubMed]  Article 
Cell React
Name:
C-terminal-binding protein 2
Synonyms:
C-terminal-binding protein 2 | C-terminal-binding protein 2 (CtBP2) | CTBP2 | CTBP2_HUMAN
Type:
Protein
Mol. Mass.:
48948.33
Organism:
Homo sapiens (Human)
Description:
P56545
Residue:
445
Sequence:
MALVDKHKVKRQRLDRICEGIRPQIMNGPLHPRPLVALLDGRDCTVEMPILKDLATVAFCDAQSTQEIHEKVLNEAVGAMMYHTITLTREDLEKFKALRVIVRIGSGYDNVDIKAAGELGIAVCNIPSAAVEETADSTICHILNLYRRNTWLYQALREGTRVQSVEQIREVASGAARIRGETLGLIGFGRTGQAVAVRAKAFGFSVIFYDPYLQDGIERSLGVQRVYTLQDLLYQSDCVSLHCNLNEHNHHLINDFTIKQMRQGAFLVNAARGGLVDEKALAQALKEGRIRGAALDVHESEPFSFAQGPLKDAPNLICTPHTAWYSEQASLEMREAAATEIRRAITGRIPESLRNCVNKEFFVTSAPWSVIDQQAIHPELNGATYRYPPGIVGVAPGGLPAAMEGIIPGGIPVTHNLPTVAHPSQAPSPNQPTKHGDNREHPNEQ
  
Syringe React
Name:
BDBM154571
Synonyms:
4-Methylthio 2-oxobutyric acid (MTOB)
Type:
Small organic molecule
Emp. Form.:
C5H8O3S
Mol. Mass.:
148.18
SMILES:
CSCCC(=O)C(O)=O
Structure:
Search PDB for entries with ligand similarity: