Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507238
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
0.690±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent US11046680 Publication Date 6/29/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM507238
Synonyms:
US11046680, Example 117.0 | US11046680, Example 118.0
Type:
Small organic molecule
Emp. Form.:
C22H25FN8O5S
Mol. Mass.:
532.548
SMILES:
CO[C@@H]([C@H](C)S(=O)(=O)Nc1nnc(-c2ccn(C)n2)n1-c1c(OC)cccc1OC)c1ncc(F)cn1 |r,wU:3.3,2.1,(4.84,-10.02,;3.5,-9.25,;3.5,-7.71,;2.17,-6.94,;2.17,-5.4,;.84,-7.71,;.07,-9.04,;1.61,-9.04,;-.5,-6.94,;-1.96,-7.42,;-2.44,-8.88,;-3.98,-8.88,;-4.45,-7.42,;-5.92,-6.94,;-7.16,-7.85,;-8.41,-6.94,;-7.93,-5.48,;-8.84,-4.23,;-6.39,-5.48,;-3.21,-6.51,;-3.21,-4.97,;-4.54,-4.2,;-5.87,-4.97,;-7.21,-4.2,;-4.54,-2.66,;-3.21,-1.89,;-1.87,-2.66,;-1.87,-4.2,;-.54,-4.97,;.79,-4.2,;4.84,-6.94,;6.17,-7.71,;7.51,-6.94,;7.51,-5.4,;8.84,-4.63,;6.17,-4.63,;4.84,-5.4,)|