Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507303
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
84.0±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent US11046680 Publication Date 6/29/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM507303
Synonyms:
US11046680, Example 182.0
Type:
Small organic molecule
Emp. Form.:
C21H21FN8O4S
Mol. Mass.:
500.506
SMILES:
COc1cccc(OC)c1-n1c(NS(=O)(=O)[C@H](C)Cc2ncc(F)cn2)nnc1-c1cnccn1 |r,wD:16.17,(-7.03,-4.33,;-5.69,-5.1,;-4.36,-4.33,;-4.36,-2.79,;-3.02,-2.02,;-1.69,-2.79,;-1.69,-4.33,;-.36,-5.1,;.98,-4.33,;-3.02,-5.1,;-3.02,-6.64,;-1.78,-7.54,;-.45,-6.77,;.89,-7.54,;-.45,-8.31,;2.22,-8.31,;2.22,-6.77,;2.22,-5.23,;3.56,-7.54,;4.89,-6.77,;6.22,-7.54,;7.56,-6.77,;7.56,-5.23,;8.89,-4.46,;6.22,-4.46,;4.89,-5.23,;-2.25,-9.01,;-3.79,-9.01,;-4.27,-7.54,;-5.81,-7.54,;-6.58,-8.87,;-8.12,-8.87,;-8.89,-7.54,;-8.12,-6.21,;-6.58,-6.21,)|