Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM507359
Substrate
n/a
Meas. Tech.
[35S]GTPgammaS Binding
EC50
226±n/a nM
Citation
Chen, N; Chen, X; Chen, Y; Cheng, AC; Connors, RV; Deignan, J; Dransfield, PJ; Du, X; Fu, Z; Harvey, JS; Heath, JA; Heumann, LV; Horne, DB; Houze, J; Kaller, MR; Kayser, F; Khakoo, AY; Kopecky, DJ; Lai, S; Ma, Z; Medina, JC; Mihalic, JT; Nishimura, N; Olson, SH; Pattaropong, V; Swaminath, G; Wang, X; Wanska, M; Yang, K; Yeh, W Heteroaryl-substituted triazoles as APJ receptor agonists US Patent US11046680 Publication Date 6/29/2021
More Info.:
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
Inhibitor
Name:
BDBM507359
Synonyms:
US11046680, Example 238.0
Type:
Small organic molecule
Emp. Form.:
C21H20N4O3S2
Mol. Mass.:
440.538
SMILES:
COc1ccccc1-n1c(NS(=O)(=O)CCc2ccccc2)nnc1-c1cccs1 |(1.37,1.43,;.03,.66,;-1.3,1.43,;-1.3,2.97,;-2.63,3.74,;-3.97,2.97,;-3.97,1.43,;-2.63,.66,;-2.63,-.88,;-1.39,-1.79,;.08,-1.31,;1.17,-2.4,;.4,-3.74,;1.94,-3.74,;2.5,-1.63,;3.83,-2.4,;5.17,-1.63,;6.5,-2.4,;7.84,-1.63,;7.84,-.09,;6.5,.68,;5.17,-.09,;-1.86,-3.25,;-3.4,-3.25,;-3.88,-1.79,;-5.34,-1.31,;-5.82,.15,;-7.36,.15,;-7.84,-1.31,;-6.59,-2.22,)|